| Budget Amount *help |
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2023: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2022: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2021: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2020: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
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| Outline of Final Research Achievements |
Voltinism is the number of generations of an insect in a year. This study aims to demonstrate that mutations in clock genes contribute to the determination of insect voltinism using the silkworm, Bombyx mori, which benefits from advanced genome engineering techniques and abundant, high-quality genomic information. By establishing knockout strains targeting core clock genes through genome editing, it was shown that the circadian clock plays a crucial role in photoperiodic diapause induction. In addition, a large-scale comparative genomic analysis identified certain clock genes and their amino acid substitutions that potentially affect the determination of voltinism in B. mori.
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