| Budget Amount *help |
¥16,380,000 (Direct Cost: ¥12,600,000、Indirect Cost: ¥3,780,000)
Fiscal Year 2023: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2022: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2021: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2020: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
|
|---|
| Outline of Final Research Achievements |
The aim of this study was to elucidate the evolutionary origins of insect metamorphosis. Using the ametabolous insect Thermobia domescita as a model, we established precise staging and egg collection methods. We investigated expression patterns of genes involved in molting and metamorphosis and found that the expression patterns of genes in the JH pathway were significantly different between ametabolous and hemimetabolous/holometabolous insects. We established methods for gene editing and transgenesis in Thermobia, and found that the adult specifier gene E93 played a key role in the evolution of insect metamorphosis, and that changes in its regulation and expansion of its functions have driven the evolution of insect metamorphosis. Our findings provide important insights into the long-standing mystery of the evolution of insect metamorphosis.
|
