| Budget Amount *help |
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2023: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2022: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2021: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
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| Outline of Final Research Achievements |
Expression dynamics of immune molecules in medaka fish were investigated and understood that the expression of inflammatory cytokines and pathogen-recognition receptors has a circadian rhythm. It was also revealed that these rhythms are regulated by a group of clock genes. Furthermore, the expression response of inflammatory cytokines was attenuated in the clock gene knockout medaka compared to immune-stimulated wild type medaka. Subsequently, it was found that infecting wild type medaka with pathogenic bacteria at different durations resulted in significant changes in mortality. Differential expression of immune molecules was observed in kidneys of wild type medaka inoculated with inactivated bacteria at different time points.
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