| Budget Amount *help |
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2022: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2021: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2020: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
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| Outline of Final Research Achievements |
Protein degradation via the ubiquitin-proteasome system has attracted much attention because of its important roles in various biological phenomena. Many E3 ubiquitin-modifying enzymes exist in vivo and play a role in determining substrate specificity. The challenge in this field is to identify these E3 target proteins and clarify their physiological significance. In this study, we identified and analyzed E3 Dma1/Dma2 for the budding yeast short-lived protein Mmr1. As a result, we elucidated the mechanism by which mitochondria, an intracellular organelle, are inherited by new cells.
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