| Budget Amount *help |
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2023: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2022: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2021: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2020: ¥9,880,000 (Direct Cost: ¥7,600,000、Indirect Cost: ¥2,280,000)
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| Outline of Final Research Achievements |
To elucidate the effect of membrane tension on membrane protein function, we established a basic system for membrane tension experiments based on our original lipid bilayer experimental method (CBB method). Using this system, we investigated the membrane tension dependence of the representative membrane protein, the potassium ion channel KcsA, at the single-molecule level. We were able to gain new insights into the structural changes that occur when the KcsA channel opens in response to tension and to identify the tension-sensing sites within the KcsA molecule.
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