| Budget Amount *help |
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2023: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2022: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2021: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2020: ¥10,400,000 (Direct Cost: ¥8,000,000、Indirect Cost: ¥2,400,000)
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| Outline of Final Research Achievements |
Amyloid nucleation is an important initial process that conducts the onset of amyloidosis. In order to elucidate how protein molecules assemble and undergo structural changes before the emergence of amyloid nuclei, we constructed an aggregation model describing that protein monomers undergo oligomerization to form protofibrils based on light scattering data. We also conducted time-resolved tracking of the maturation process of protofibril-like aggregates into amyloid fibrils. In addition, we found gradual changes in fibril structure during the nucleation on the surface of amyloid fibrils.
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