Budget Amount *help |
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2023: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2022: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2021: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
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Outline of Final Research Achievements |
Overexpression of proteins can harm cells in various ways. Using budding yeast as a model for eukaryotic cells, we have investigated the characteristics of protein groups that cause growth inhibition when overexpressed and have classified the mechanisms of growth inhibition. In this study, we further explored the toxicity mechanisms by introducing mutations into proteins that cause growth inhibition. As a result, we revealed that the presence of specific amino acids or the activity of the protein itself can lead to growth inhibition.
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