| Budget Amount *help |
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2022: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2021: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000)
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| Outline of Final Research Achievements |
In recent years, as genome sequencing has become easier, mutations in KIF1A have been reported in a number of arcuate congenital neurological diseases. We analyzed KIF1A-associated neurological diseases using single-molecule-level molecular motor motility analysis methods and the nematode Caenorhabditis elegans to elucidate the molecular mechanisms underlying the pathogenesis of these diseases and to gain new insights into the molecular mechanisms of axonal transport.
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