| Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2023: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2022: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2021: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
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| Outline of Final Research Achievements |
Vascular system plays a pivotal role in conveying oxygen and nutrients, and its formation and patterning during early developing follow some rules. In this study, we asked how the blood flow regulates the vascular patterning. In early chicken embryos, geometric patterns of vitelline arteries (VAs) that laterally extend from the dorsal aorta at the level of 20th somites facilitate analyses at high resolution. We found that the onset of hear beat-driven blood flow is intimately correlated with the he VA patterning. An occlusion of blood flow markedly affected the VA patterning, suggesting that the mechanical stimulation by blood flow plays an important role. We further found that Rho activity needs to be properly controlled for the blood flow-regulated VA patterning. The findings obtained in this study are expected to help understanding how blood flow regulates tumor and cancer cells.
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