| Budget Amount *help |
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2022: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2021: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2020: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
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| Outline of Final Research Achievements |
Sex determination and sex differentiation are the most important events in the survival of a species, and many transcription factors involved in sex determination have been identified, including the sex determination gene Sry on the Y chromosome. On the other hand, how the epigenome is involved in sex determination is still poorly understood. In this study, we searched for proteins that bind to Jmjd1a to elucidate the mechanism by which Jmjd1a, a histone H3K9 demethylase, targets the Sry locus. As a result, we identified a novel Zn finger protein as a candidate.
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