| Budget Amount *help |
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2023: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2022: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2021: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2020: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
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| Outline of Final Research Achievements |
Based on our finding that dosage compensation equalizing X-linked gene expression between the sexes is absent in primordial germ cells (PGCs), this study has trying to clarify the cell-autonomous mechanism regulating sex determination of the germline. Here, we report the possibility that overexpression of the essential components of MSL complex, which is required for dosage compensation in Drosophila, causes feminization of XY (male) PGCs, and that nanos gene is involved in the absence of dosage compensation in PGCs. Furthermore, we identified a novel-candidate X-linked gene involved in feminization of PGCs. These results provide a basis for understanding the mechanisms of sex determination in the germline.
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