| Budget Amount *help |
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2022: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2021: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2020: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
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| Outline of Final Research Achievements |
This study aimed to elucidate the mechanisms underlying wing reduction in emus. Our analyses showed that the immobilization resulting from the absence of distal muscles contributes to the shortening, the loss of synovial joints, and the left-right asymmetric phenotypic variation observed. Further analyses identified a population of muscle progenitors displaying a dual transcriptional cell signature. These muscle progenitors aggregated at the proximal region of the wing buds and are responsible for the morphological features seen in the wings of emus. These findings demonstrate that differential mobility during embryonic development may underlie the evolution of vestigial structures.
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