| Budget Amount *help |
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2023: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2022: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2021: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2020: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
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| Outline of Final Research Achievements |
To elucidate the molecular mechanisms of synaptic plasticity of glutamate and GABA co-release, we examined the synaptic plasticity at the supramammillary nucleus (SuM) to dentate granule cell (GC) synapses. By postsynaptic depolarization, we found that glutamatergic SuM inputs exhibit long-term potentiation (LTP), while GABAergic co-transmission is not influenced. Owing to the dynamic change of excitatory and inhibitory balance of SuM inputs after induction of LTP, SuM inputs effectively discharge GCs. We further found that SuM-GC synapses exhibit spike-timing-dependent plasticity. Our findings indicate that SuM-GC synapses elicit different forms of plasticity and modulate GC outputs.
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