| Budget Amount *help |
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2022: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2021: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2020: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
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| Outline of Final Research Achievements |
In mast cells from mice deficient in both Cyp4a12a and Cyp4a12b, IgE/antigen-stimulated activation was markedly attenuated. This attenuation was restored by epoxidized omega-3 fatty acids. TR4 markedly increased Srcin1 promoter activity, and is involved in Srcin1 expression in bone marrow-derived mast cells. These findings indicate that TR4 is essential for Srcin1 expression in mast cells and that epoxy omega-3 fatty acids produced by the Cyp4a12a/b-PAF-AH2 axis regulate Srcin1 expression by suppressing TR4 function.
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