| Budget Amount *help |
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2023: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2022: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2021: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2020: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
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| Outline of Final Research Achievements |
Cardiac-specific GPx4-deficient mice can survive on a vitamin E-supplemented diet, but when dietary vitamin E levels are reduced, lipid oxidation-dependent cell death (ferroptosis-like cell death) is induced in cardiomyocytes, leading to sudden cardiac death. We have previously found that drinking water administration of cefoperazone (CPZ), an antibiotic with no antioxidant capacity, suppressed heart failure via changes in the gut microbiota. In this study, we found that the CPZ-resistant enterobacteria are identified and that they recognize and require trace amounts of vitamin E structure in the gut for this lethal inhibition, and we newly found that at least two other types of enterobacteria besides can also inhibit heart failure.
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