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Neurophysiological investigation of the innate cognition system (extrageniculate visual system) responsible for primate brain evolution

Research Project

Project/Area Number 20H03417
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 48020:Physiology-related
Research InstitutionUniversity of Toyama

Principal Investigator

Nishijo Hisao  富山大学, 学術研究部医学系, 特別研究教授 (00189284)

Project Period (FY) 2020-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2022: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2021: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2020: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
Keywords本能的認知 / 膝状体外視覚系 / 上丘 / 扁桃体 / ガンマオシレーション / ヘビ / 顔 / 霊長類
Outline of Research at the Start

霊長類は膝状体外視覚系(網膜→上丘→視床枕→扁桃体等)により、同種の顔および天敵であるヘビに対して本能行動を示す。本研究では、霊長類であるサルを用い、上丘および扁桃体ニューロンのヘビ、サルおよびヒトの顔、ならびに猛禽類と肉食獣に対する応答性を比較・解析することにより、作業仮説「霊長類の脳は猛禽類や肉食獣と比較してヘビと顔に反応性が高く、さらに顔に対しては同種の顔に反応性が高い」を検証する。

Outline of Final Research Achievements

Primates such as humans and monkeys can detect snakes, their natural enemies, more quickly than other animals, even in snake-unexperienced individuals. To clarify the innate recognition mechanism of snakes and faces in primates, we analyzed the responsiveness of the monkey extrastriate visual system (superior colliculus and amygdala) to visual stimuli. The results revealed that 1) amygdalar and superior collicular neurons responded to snakes and faces of the same species more rapidly and strongly with a shorter latency than to those of other animals, and 2) these superior collicular and amygdalar neurons showed gamma oscillations with a short latency specifically to snakes. These findings suggest that the extrastriate visual system functions as a quick ascending information processing system, especially in snakes.

Academic Significance and Societal Importance of the Research Achievements

ヘビは人類を含む霊長類共通の天敵であり、人類の脳はヘビを検出する視覚能力を高めるために進化してきたことが示唆されている(ヘビ検出仮説)。例えばヘビ検出仮説を支持するデータとして、1)ヘビを未経験である小児やサルでも、ヘビを素早く検出し、恐怖症状を示す、2)ヒトでは、恐怖症の対象物としてヘビの頻度が高いことなどが報告されている。本研究結果は、これら行動学的データに神経科学的基盤を与えるものである。

Report

(4 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Annual Research Report
  • 2020 Annual Research Report
  • Research Products

    (13 results)

All 2022 2021 2020 Other

All Int'l Joint Research (4 results) Journal Article (4 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 3 results,  Open Access: 2 results) Presentation (5 results)

  • [Int'l Joint Research] ベトナム軍医大学(ベトナム)

    • Related Report
      2022 Annual Research Report
  • [Int'l Joint Research] ベトナム軍医大学(ベトナム)

    • Related Report
      2021 Annual Research Report
  • [Int'l Joint Research] べトナム軍医大学(ベトナム)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] ブラジリア大学(ブラジル)

    • Related Report
      2020 Annual Research Report
  • [Journal Article] Fast detection of snakes and emotional faces in the macaque amygdala.2022

    • Author(s)
      Dinh HT, Meng Y, Matsumoto J, Setogawa T, Nishimaru H, Nishijo H
    • Journal Title

      Front. Behav. Neurosci.

      Volume: 16 Pages: 839123-839123

    • DOI

      10.3389/fnbeh.2022.839123

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Involvement of the extrageniculate subcortical visual pathway in innate recognition in primates.2022

    • Author(s)
      Nishijo H, Nishimaru H, Ono T.
    • Journal Title

      Toyama Med. Journal

      Volume: 32 Pages: 1-14

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 総説 霊長類における顔の本能的認知機構2021

    • Author(s)
      西条寿夫, 小野武年
    • Journal Title

      BRAIN and NERVE

      Volume: 73 Issue: 12 Pages: 1363-1369

    • DOI

      10.11477/mf.1416201948

    • ISSN
      1344-8129, 1881-6096
    • Year and Date
      2021-12-01
    • Related Report
      2021 Annual Research Report
  • [Journal Article] Preferential Neuronal Responses to Snakes in the Monkey Medial Prefrontal Cortex Support an Evolutionary Origin for Ophidiophobia2021

    • Author(s)
      Dinh HT, Nishimaru H, Le QV, Matsumoto J, Setogawa T, Maior RS, Tomaz C, Ono T and Nishijo H
    • Journal Title

      Frontiers in Behavioral Neuroscience

      Volume: 15 Pages: 653250-653250

    • DOI

      10.3389/fnbeh.2021.653250

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Superior Neuronal Detection of Snakes and Faces in The Macaque Superior Colliculus and Its Biological Relevance2022

    • Author(s)
      Tsuyoshi Setogawa, Quan Van Le, Ha Trong Dinh, Hiroshi Nishimaru, Jumpei Matsumoto, Hisao Nishijo
    • Organizer
      第45回日本神経科学大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 顔やヘビ画像に対するサル上丘の素早く強いニューロン応答2022

    • Author(s)
      瀬戸川剛、Quan Van Le、Ha Trong Dinh、西丸広史、松本惇平、堀悦郎、西条寿夫
    • Organizer
      第11回日本情動学会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Preferential neuronal responsiveness to snake images in the monkey medial prefrontal cortex is involved in the development of ophidiophobia2021

    • Author(s)
      Yang M, Dinh TH, Nishimaru H, Le VQ, Matsumoto J, Setogawa T, Ono T, Nishijo H
    • Organizer
      日本神経科学会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Snake and face images-selective neuronal responses in the monkey amygdala2021

    • Author(s)
      Yang Meng, Ha Trong Dinh, Hiroshi Nishimaru, Jumpei Matsumoto,Tsuyoshi Setogawa, Taketoshi Ono and Hisao Nishijo
    • Organizer
      第98回日本生理学会大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Monkey amygdalar neurons preferentially respond to snake pictures.2020

    • Author(s)
      Ha Trong Dinh, Yang Meng, Hiroshi Nishimaru, Jumpei Matsumoto, Tsuyoshi Setogawa, Taketoshi Ono, Hisao Nishijo
    • Organizer
      第67回中部日本生理学会
    • Related Report
      2020 Annual Research Report

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Published: 2020-04-28   Modified: 2024-01-30  

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