| Budget Amount *help |
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2022: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2021: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2020: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
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| Outline of Final Research Achievements |
Synaptic transmission efficiency is believed to change in response to external stimuli such as learning and the environment. We have revealed that the efficiency of central synapses is controlled by the nanoscale arrangement of synaptic proteins, highlighting the importance of fine molecular organization of synapses in understanding the mechanisms of higher brain functions. This study aimed to elucidate the changes in the nanoscale arrangement of synaptic molecules in response to external stimuli in animals. Specifically, we established a super-resolution microscopy platform to visualize the synaptic molecular localization in the mouse brain and revealed the fine changes in synaptic molecular organization caused by differences in housing conditions.
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