| Budget Amount *help |
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2023: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2022: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2021: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
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| Outline of Final Research Achievements |
This study has established that Th17 cells and Tregs are differently oriented in lipid metabolism through the identification of the responsible lipid LPE (1-18:1) and metabolic enzyme cascade that controls RORgt activity in Th17 cells, as well as the role of the Acsbg1 enzyme in regulating tissue-resident Treg homeostasis and environmental lipid intake. We were able to establish that Th17 cells and Tregs differ in their orientation of lipid metabolism. We have summarized these results in a number of publications, including in Science Immunology and Cell Reports. Currently, we are continuing our research and conducting more detailed analysis of how specific qualities are responsible for each cellular function by generating point mutant mice.
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