| Budget Amount *help |
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2023: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2022: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2021: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2020: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
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| Outline of Final Research Achievements |
Thymus-derived regulatory T cells (Tregs) are characterized by their ability to recognize self-antigens, but the mechanism of their differentiation is not well understood. The transcription factor Fezf2 is involved in negative selection, but it was unclear whether it is involved in Treg differentiation. In this research project, we sought to identify functional molecules involved in Tregs selected in the thymus. By analyzing Fezf2-deficient mice, the applicant found that certain Treg subsets are involved in development and in cancer and autoimmune diseases in central nervous tissue. These findings are important for the development of treatments for various nervous system diseases.
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