Identification of microbiota-associated metabolite which protects against
| Project/Area Number |
20H03490
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Review Section |
Basic Section 49050:Bacteriology-related
|
|---|
| Research Institution | Keio University |
|---|
Principal Investigator |
Kim Yun-Gi 慶應義塾大学, 薬学部(芝共立), 教授 (00620220)
|
|---|
| Project Period (FY) |
2020-04-01 – 2023-03-31
|
| Project Status |
Completed (Fiscal Year 2022)
|
| Budget Amount *help |
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2022: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2021: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2020: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
|
|---|
| Keywords | 腸内細菌 / 肥満 / 代謝物 |
|---|
| Outline of Research at the Start |
肥満は世界的に増加傾向にあり、致命的な慢性疾患を引き起こすリスクを上昇させることが知られている。そのため、肥満の抑制は予防医学上極めて重要な課題となっている。近年、腸内細菌が肥満の制御に重要な役割を果たしていることが次第に明らかになってきたが、その分子メカニズムについてはほとんど明らかになっていない。本研究は、腸内細菌による肥満の抑制メカニズムを解明することを目的とする。
|
| Outline of Final Research Achievements |
Obesity is on the rise worldwide and is known to increase the risk of fatal chronic diseases. Therefore, the control of obesity has become an extremely important issue in preventive medicine. In recent years, it has been strongly suggested that gut microbiota are deeply involved in the control of obesity. In this study, we have found that obesity pathophysiology is strongly suppressed in the mice fed a high-fat diet by changing the composition of gut microbiota (obesity-resistant mice). Furthermore, through integrated omics analysis using the obesity-resistant mice, we were able to identify novel gut microbes and their metabolites correlated with the suppression of obesity.
|
| Academic Significance and Societal Importance of the Research Achievements |
腸内細菌叢が宿主の代謝機能に影響を与えていることが次第に明らかになってきたが、腸内細菌による肥満抑制の詳細なメカニズムについては不明な点が多く残されている。そのため、我々は肥満の制御に関わる腸内細菌およびその代謝物を探索し、その作用メカニズムを解明したいと考えた。本研究により、腸内細菌叢を変化させることにより高脂肪食負荷後の体重増加や耐糖能の悪化が強く抑制される肥満抵抗性マウスを作製することができた。この肥満抵抗性マウスを解析することで、宿主の代謝機能低下を抑制する未同定の腸内細菌由来の代謝物およびその作用メカニズムを明らかにできる可能性があり、学術的・社会的意義は非常に高いと考えている。
|
Report
(4 results)
Research Products
(32 results)
-
[Journal Article] Colonization of the live biotherapeutic product VE303 and modulation of the microbiota and metabolites in healthy volunteers2022
Author(s)
Dsouza M, Menon R, Crossette E, Bhattarai S, Schneider J, Kim YG, Reddy S, Caballero S, Felix C, Cornacchione L, Hendrickson J, Watson A, Minot S, Greenfield N, Schopf L, Szabady R, Patarroyo J, Smith W, Harrison P, Kuijper E, Kelly C, Olle B, Bobilev D, Bucci V, Roberts B, Faith J, Norman J.
-
Journal Title
Cell Host & Microbe
Volume: 30
Issue: 4
Pages: 583-598.e8
DOI
Related Report
Peer Reviewed / Int'l Joint Research
-
-
-
-
-
-
-
-
-
[Journal Article] Macropinocytosis and SARS-CoV-2 cell entry2021
Author(s)
Sun X., Zheng W., Hua R., Liu Y., Wang L., Kim Y.G. , Liu X., Mimuro H., Shen Z., Li L., Yoshida S.
-
Journal Title
Blood and Genomics
Volume: 5(1)
Pages: 1-12
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
-
[Journal Article] Seaweed dietary fiber sodium alginate suppresses the migration of colonic inflammatory monocytes and diet-induced metabolic syndrome via the gut microbiota2021
Author(s)
Ejima R., Akiyama M., Sato H., Tomioka S., Yakabe K., Kimizuka T., Seki N., Fujimura Y., Hirayama A., Fukuda S., Hase K., Kim Y.G.
-
Journal Title
Nutrients
Volume: 13(8)
Issue: 8
Pages: 2812-2812
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
-
[Journal Article] Commensal microbe-derived acetate suppresses NAFLD/NASH development via hepatic FFAR2 signalling in mice2021
Author(s)
Aoki R., Onuki M., Hattori K., Ito M., Yamada T., Kamikado K., Kim Y.G., Nakamoto N., Kimura I., Clarke J.M., Kanai T, Hase K.
-
Journal Title
Microbiome
Volume: 9(1)
Issue: 1
Pages: 188-188
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
