| Budget Amount *help |
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2022: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2021: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2020: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
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| Outline of Final Research Achievements |
Obesity is on the rise worldwide and is known to increase the risk of fatal chronic diseases. Therefore, the control of obesity has become an extremely important issue in preventive medicine. In recent years, it has been strongly suggested that gut microbiota are deeply involved in the control of obesity. In this study, we have found that obesity pathophysiology is strongly suppressed in the mice fed a high-fat diet by changing the composition of gut microbiota (obesity-resistant mice). Furthermore, through integrated omics analysis using the obesity-resistant mice, we were able to identify novel gut microbes and their metabolites correlated with the suppression of obesity.
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