| Budget Amount *help |
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2022: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2021: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2020: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
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| Outline of Final Research Achievements |
The increased activity of the glycolytic system upon T cell antigen recognition is required for activation of glutamine metabolism, and glutamine maintains activation of the glycolytic system via sustained activity of mTOR. In other words, it was suggested that the glycolytic system and glutamine metabolism may form a feed-forward loop to prolong signals via TCR and cytokine receptors and maintain T cell activation. These results indicate that glycolytic activation in T cells upon antigen recognition is essential for the induction of normal T cell-dependent immune responses and is a therapeutic target for the treatment of immunological diseases. We also found that glutamine may regulate T cellular senescence via modulation of autophagy.
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