RB1 tumor suppressor functions in metabolism

• Project/Area Number: 20H03509
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Review Section: Basic Section 50010:Tumor biology-related
• Research Institution: Kanazawa University
• Principal Investigator: Takahashi Chiaki 金沢大学, がん進展制御研究所, 教授 (50283619)
• Project Period (FY): 2020-04-01 – 2024-03-31
• Project Status: Completed (Fiscal Year 2023)
• Budget Amount: ¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000); Fiscal Year 2023: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2022: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2021: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2020: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
• Keywords: がん抑制遺伝子 / がん代謝 / 解糖系 / ミトコンドリア / 脂質代謝 / RB1 / がん / RB / RAS / CDK4/6阻害剤 / KRAS阻害剤 / ELOVL6 / SUCLA2 / 代謝 / CDK阻害剤 / CDK2/4/6阻害剤 / 治療抵抗性 / EGFR / AMPK / CDK / Ras / 未分化性 / コレステロール / PGAM1,2 / セラミド / 炎症

Outline of Research at the Start

RB１がん抑制遺伝子産物が、細胞周期の調節や組織特異的転写因子との協調に加え、代謝を巧妙に調節する事によって、細胞の未分化な挙動を制御する可能性を見出している。本研究では、RB1の糖代謝、脂質代謝、コレステロール代謝、栄養シグナル、核酸代謝における機能を探索、解明することによって、がん治療の標的としてのがん代謝の本態に迫る。また、RB1の標的中臨床的に意義の高い遺伝子のがん治療分子標的としてのPOCを地区制する。

Outline of Final Research Achievements

We found that the RB1-PGAM axis positively controls muscle differentiation. Inhibition of the RB1 downstream gene ELOVL6 in breast cancer showed growth suppression. We found that ceramide production increases following ELOVL6 inhibition, which suppresses AKT signaling. We elucidated the action of cholesterol as a fate metabolite regulated by RB1. We found a mechanism whereby the regulation of the isoprenylation pathway by RB1 is compensated for by p130. We found that early resistance of RB1 wild-type hepatocellular carcinoma to CDK4/6 inhibitors depends on IKKb-NF-kB and AKT activity. We explored rationales for adaptation of CDK4/6 inhibitor combination therapy recipe for KRAS mutant pancreatic cancer.

Academic Significance and Societal Importance of the Research Achievements

RB1不活性化は、発がん時よりもむしろ悪性進展時において頻繁である。この帰結は、未分化性・薬剤耐性誘導、腫瘍微小環境の改編や代謝リプログラミングなど、従来知られた細胞周期制御の破綻では説明できない事象群である。本研究は、細胞内の代謝制御におけるRB1機能に焦点を当て、解糖系、脂質合成系、コレステロール合成、脂肪酸酸化、核酸代謝系において特異的なRB1標的を見出し、この生物学的・臨床的意義を探索した。このような非古典的なRB1標的のなかには、新規がん治療標的として有望な分子が含まれるかもしれない。

Research Products

• [Int'l Joint Research] ハーバード大学/ジョンスホプキンス大学/ブラウン大学(米国)
• [Int'l Joint Research] 南オーストラリア大学(オーストラリア)
• [Int'l Joint Research] 上海交通大学附属病院/復旦大学(中国)
• [Int'l Joint Research] 南オーストラリア大学(オーストラリア)
• [Int'l Joint Research] ジョンスホプキンス大学(米国)
• [Int'l Joint Research] カトリック大学(チリ)
• [Int'l Joint Research] サンクトペテルブルグ医科大学(ロシア連邦)
• [Int'l Joint Research] 南オーストラリア大学(オーストラリア)
• [Int'l Joint Research] サンクトペテルブルグ医科大学(ロシア連邦)
• [Journal Article] Differential requirement for IL-2 and IL-23 in the differentiation and effector functions of Th17/ILC3-like cells in a human T cell line (2024)
  • Author(s): Momtazkari Sarah、Dev Choudhury Anahita、Yong Zachary Wei Ern、Le Dong Thanh、Nguyen Canh Hiep、Harada Kenichi、Hori Toshiyuki、Osato Motomi、Takahashi Chiaki、Koh Cai Ping、Voon Dominic Chih-Cheng
  • Journal Title: Journal of Leukocyte Biology Volume: - Issue: 6 Pages: 1108-1117
  • DOI: 10.1093/jleuko/qiae034
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Drug-drug conjugates of MEK and Akt inhibitors for RAS-mutant cancers (2024)
  • Author(s): Fujita Hikaru、Arai Sachiko、Arakawa Hiroshi、Hamamoto Kana、Kato Toshiyuki、Arai Tsubasa、Nitta Nanaka、Hotta Kazuki、Hosokawa Natsuko、Ohbayashi Takako、Takahashi Chiaki、Inokuma Yasuhide、Tamai Ikumi、Yano Seiji、Kunishima Munetaka、Watanabe Yoshihiro
  • Journal Title: Bioorganic & Medicinal Chemistry Volume: 102 Pages: 117674-117674
  • DOI: 10.1016/j.bmc.2024.117674
  • Peer Reviewed
• [Journal Article] RB1 loss induces quiescent state through downregulation of RAS signaling in mammary epithelial cells. (2023)
  • Author(s): Gong L, Voon DC, Nakayama J, Takahashi C and Kohno S.
  • Journal Title: Cancer Sci. Volume: -
  • Peer Reviewed
• [Journal Article] NFYA promotes malignant behavior of triple-negative breast cancer in mice through the regulation of lipid metabolism (2023)
  • Author(s): Okada Nobuhiro、Ueki Chihiro、Shimazaki Masahiro、Tsujimoto Goki、Kohno Susumu、Muranaka Hayato、Yoshikawa Kiyotsugu、Takahashi Chiaki
  • Journal Title: Communications Biology Volume: 6 Issue: 1 Pages: 596-596
  • DOI: 10.1038/s42003-023-04987-9
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Inhibition of the mitochondria-shaping protein Opa1 restores sensitivity to Gefitinib in a lung adenocarcinomaresistant cell line (2023)
  • Author(s): Noguchi Masafumi、Kohno Susumu、Pellattiero Anna、Machida Yukino、Shibata Keitaro、Shintani Norihito、Kohno Takashi、Gotoh Noriko、Takahashi Chiaki、Hirao Atsushi、Scorrano Luca、Kasahara Atsuko
  • Journal Title: Cell Death & Disease Volume: 14 Issue: 4 Pages: 1-10
  • DOI: 10.1038/s41419-023-05768-2
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The germline factor DDX4 contributes to the chemoresistance of small cell lung cancer cells (2023)
  • Author(s): Noyes Christopher、Kitajima Shunsuke、Li Fengkai、Suita Yusuke、Miriyala Saradha、Isaac Shakson、Ahsan Nagib、Knelson Erik、Vajdi Amir、Tani Tetsuo、Thai Tran C.、Xu Derek、Murai Junko、Tapinos Nikos、Takahashi Chiaki、Barbie David A.、Yajima Mamiko
  • Journal Title: Communications Biology Volume: 6 Issue: 1
  • DOI: 10.1038/s42003-023-04444-7
  • Peer Reviewed
• [Journal Article] The transcription factor ATF3 switches cell death from apoptosis to necroptosis in hepatic steatosis in male mice (2023)
  • Author(s): Inaba Yuka、Hashiuchi Emi、Watanabe Hitoshi、Kimura Kumi、Oshima Yu、Tsuchiya Kohsuke et al.
  • Journal Title: Nature Communications Volume: 14 Issue: 1 Pages: 167-167
  • DOI: 10.1038/s41467-023-35804-w
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Inactivation of CSGALNACT2 Promotes Ovarian Cancer Migration and Invasion Through the MAPK/ERK Signaling Pathway. (2023)
  • Author(s): 4.Ma M, Wu M, Gu S, Yang J, Wang C, Zhang Y, Cheng S, Xu S, Zhang M, Wu Y, Zhao Y, Tian X, Takahashi C, Sheng J, and Wang Y
  • Journal Title: Cellular Oncol Volume: -
  • Peer Reviewed
• [Journal Article] Inhibition of the mitochondria-shaping protein Opa1 restores sensitivity to Gefitinib in a lung adenocarcinoma resistant cell.Cell Death & Disease. (2023)
  • Author(s): Noguchi M, Kohno S, Pellattiero A, Machida Y, Shibata K, Shintani N, Kohno T, Gotoh N, Takahashi C, Hirao A, Kasahara A, and Scorrano L.
  • Journal Title: Cell Death & Disease Volume: -
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] The germline factor DDX4 contributes to the chemoresistance of small cell lung cancer cells (2023)
  • Author(s): Noyes C, Kitajima S, Li F, Suita Y, Miriyala S, Isaac S, Ahsan N, Knelson E, Vajdi A, Tani T, Thai TC, Xu D, Murai J, NTapinos N, Takahashi C, Barbie DA and Yajima M.
  • Journal Title: Commun. Biol Volume: -
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] NFYA promotes the malignant behavior of triple-negative breast cancer through the regulation of lipid metabolism (2022)
  • Author(s): Okada Nobuhiro、Ueki Chihiro、Shimazaki Masahiro、Tsujimoto Goki、Kohno Susumu、Muranaka Hayato、Yoshikawa Kiyotsugu、Takahashi Chiaki
  • Journal Title: bioRxiv Volume: -
  • DOI: 10.1101/2022.05.26.493660
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] RHEB is a potential therapeutic target in T cell acute lymphoblastic leukemia (2022)
  • Author(s): Pham Loc Thi、Peng Hui、Ueno Masaya、Kohno Susumu、Kasada Atuso、Hosomichi Kazuyoshi、Sato Takehiro、Kurayoshi Kenta、Kobayashi Masahiko、Tadokoro Yuko、Kasahara Atsuko、Shoulkamy Mahmoud I.、Xiao Bo、Worley Paul F.、Takahashi Chiaki、Tajima Atsushi、Hirao Atsushi
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 621 Pages: 74-79
  • DOI: 10.1016/j.bbrc.2022.06.089
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Targeting Abnormal Cell Cycle in Cancer: A Preface to the Special Issue (2022)
  • Author(s): Takahashi Chiaki、Kato Jun-ya
  • Journal Title: Onco Volume: 2 Issue: 1 Pages: 34-35
  • DOI: 10.3390/onco2010003
  • Peer Reviewed
• [Journal Article] Selenoprotein P-mediated reductive stress impairs cold-induced thermogenesis in brown fat. (2022)
  • Author(s): Oo SM, Oo HK, Takayama H, Ishii KA, Takeshita Y, Goto H, Nakano Y, Kohno S, Takahashi C, Nakamura H, Saito Y, Matsushita M, Okamatsu-Ogura Y, Saito M and Takamura T.
  • Journal Title: Cell Reports Volume: 38
  • Peer Reviewed
• [Journal Article] Selenoprotein P-mediated reductive stress impairs cold-induced thermogenesis in brown fat. (2022)
  • Author(s): Oo SM, Oo HK, Takayama H, Ishii KA, Takeshita Y, Goto H, Nakano Y, Kohno S, Takahashi C, Nakamura H, Saito Y, Matsushita M, Okamatsu-Ogura Y, Saito M and Takamura T.
  • Journal Title: Cell Reports 3 Volume: 38 Pages: 110566-110566
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Targeting RB1 Loss in Cancers (2021)
  • Author(s): Linn Paing、Kohno Susumu、Sheng Jindan、Kulathunga Nilakshi、Yu Hai、Zhang Zhiheng、Voon Dominic、Watanabe Yoshihiro、Takahashi Chiaki
  • Journal Title: Cancers Volume: 13 Issue: 15 Pages: 3737-3737
  • DOI: 10.3390/cancers13153737
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Chemical inducer of regucalcin attenuates lipopolysaccharide‐induced inflammatory responses in pancreatic MIN6 β‐cells and RAW264.7 macrophages (2021)
  • Author(s): Murata Tomiyasu、Hashimoto Kazunori、Kohno Susumu、Takahashi Chiaki、Yamaguchi Masayoshi、Ito Chihiro、Masataka Itoigawa、Kojima Roji、Hikita Kiyomi、Kaneda Norio
  • Journal Title: FEBS Open Bio Volume: 12 Issue: 1 Pages: 175-191
  • DOI: 10.1002/2211-5463.13321
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Treatment of Retinoblastoma 1?Intact Hepatocellular Carcinoma With Cyclin‐Dependent Kinase 4/6 Inhibitor Combination Therapy (2021)
  • Author(s): Sheng Jindan、Kohno Susumu、Okada Nobuhiro、Okahashi Nobuyuki、Teranishi Kana、Matsuda Fumio、Shimizu Hiroshi、Linn Paing、Nagatani Naoko、Yamamura Minako、Harada Kenichi、Horike Shin‐ichi、Inoue Hiroshi、Yano Seiji、Kumar Sharad、Kitajima Shunsuke、Ajioka Itsuki、Takahashi Chiaki
  • Journal Title: Hepatology Volume: 74 Issue: 4 Pages: 1971-1993
  • DOI: 10.1002/hep.31872
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Reduced RECK levels accelerate skeletal muscle differentiation, improve muscle regeneration, and decrease fibrosis (2021)
  • Author(s): Gutierrez Jaime、Gonzalez David、Escalona‐Rivano Rodrigo、Takahashi Chiaki、Brandan Enrique
  • Journal Title: The FASEB Journal Volume: 35 Issue: 5
  • DOI: 10.1096/fj.202001646rr
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] GDE2-RECK controls ADAM10 α-secretase mediated cleavage of amyloid precursor protein (2021)
  • Author(s): Nakamura Mai、Li Yuhan、Choi Bo-Ran、Matas-Rico Elisa、Troncoso Juan、Takahashi Chiaki、Sockanathan Shanthini
  • Journal Title: Science Translational Medicine Volume: 13 Issue: 585
  • DOI: 10.1126/scitranslmed.abe6178
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Essential role of autophagy in protecting neonatal haematopoietic stem cells from oxidative stress in a p62-independent manner (2021)
  • Author(s): Nomura Naho、Ito Chiaki、Ooshio Takako、Tadokoro Yuko、Kohno Susumu、Ueno Masaya、Kobayashi Masahiko、Kasahara Atsuko、Takase Yusuke、Kurayoshi Kenta、Si Sha、Takahashi Chiaki、Komatsu Masaaki、Yanagawa Toru、Hirao Atsushi
  • Journal Title: Scientific Reports Volume: 11 Issue: 1 Pages: 1666-1679
  • DOI: 10.1038/s41598-021-81076-z
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Synthetic inhibitors of CDK4/6 activities and tumor suppression: a preface to the special issue. (2021)
  • Author(s): Takahashi C and Kato J.
  • Journal Title: Onco Volume: 1 Issue: 1 Pages: 1-2
  • DOI: 10.3390/onco1010001
  • Peer Reviewed
• [Journal Article] Peripubertal high‐fat diet promotes c‐Myc stabilization in mammary gland epithelium (2020)
  • Author(s): Kulathunga Nilakshi、Kohno Susumu、Linn Paing、Nishimoto Yuuki、Horike Shin‐ichi、Zaraiskii Mikhail I.、Kumar Sharad、Muranaka Hayato、Takahashi Chiaki
  • Journal Title: Cancer Science Volume: 111 Issue: 7 Pages: 2336-2348
  • DOI: 10.1111/cas.14492
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Pharmacologically targetable vulnerability in prostate cancer carrying RB1-SUCLA2 deletion (2020)
  • Author(s): Kohno Susumu、Linn Paing、Nagatani Naoko、Watanabe Yoshihiro、Kumar Sharad、Soga Tomoyoshi、Takahashi Chiaki
  • Journal Title: Oncogene Volume: 39 Issue: 34 Pages: 5690-5707
  • DOI: 10.1038/s41388-020-1381-6
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] mDia1/3-dependent actin polymerization spatiotemporally controls LAT phosphorylation by Zap70 at the immune synapse. (2020)
  • Author(s): Thumkeo, D., Katsura, Y., Nishimura, Y., Kanchanawong, P., Tohyama, K., Ishizaki, T., Kitajima, S., Takahashi, C., Hirata, T., Watanabe, N., Krummel, M. F., and Narumiya, S.
  • Journal Title: Sci. Adv. Volume: 6 Issue: 1 Pages: 2432-2432
  • DOI: 10.1126/sciadv.aay2432
  • NAID: 120006777011
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] MicroRNA in monitoring of the evolution of glial cerebral tumors. (2020)
  • Author(s): Seliverstov RY, Zaraiskiy MI, Tyurin RV, Naryshkin AG, Valerko VG, Semiglazov VV and Takahashi C.
  • Journal Title: Siberian Journal of Oncology Volume: 19 Issue: 3 Pages: 47-53
  • DOI: 10.21294/1814-4861-2020-19-3-47-53
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Regucalcin enhances adipocyte differentiation and attenuates inflammation in 3T3‐L1 cells (2020)
  • Author(s): Murata Tomiyasu、Yamaguchi Masayoshi、Kohno Susumu、Takahashi Chiaki、Risa Watanabe、Hatori Kanna、Hikita Kiyomi、Kaneda Norio
  • Journal Title: FEBS Open Bio Volume: 10 Issue: 10 Pages: 1967-1984
  • DOI: 10.1002/2211-5463.12947
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Tumor Milieu Controlled by RB Tumor Suppressor. (2020)
  • Author(s): Kitajima S, Li F, Takahashi C.
  • Journal Title: Int J Mol Sci., Volume: 21 Issue: 7 Pages: 1-1
  • DOI: 10.3390/ijms21072450
  • Peer Reviewed / Int'l Joint Research
• [Presentation] The mechanism whereby PDAC resists to CDK inhibition. (2023)
  • Author(s): Zhang Y, Gothwal KS, Kohno S and Takahashi C.
  • Organizer: 第82回日本癌学会学術総会
  • Int'l Joint Research
• [Presentation] 2-OG代謝を標的としたRB-SUCLA2欠失前立腺がん治療法の確立 (2023)
  • Author(s): 河野晋, 高橋智聡
  • Organizer: 第82回日本癌学会学術総会
  • Int'l Joint Research
• [Presentation] 膵がんのCDK阻害剤耐性発現機構 (2023)
  • Author(s): 高橋智聡
  • Organizer: 第61回日本癌治療学会学術集会
  • Int'l Joint Research
• [Presentation] Targeting RB1 status in cancer. (2023)
  • Author(s): Takahashi C
  • Organizer: Gynecologic Oncology Symposium (Shanghai)
  • Int'l Joint Research / Invited
• [Presentation] KRAS阻害剤の基礎 (2023)
  • Author(s): 高橋智聡
  • Organizer: 日本放射線腫瘍学会第36回学術大会
  • Int'l Joint Research / Invited
• [Presentation] RB欠失による脆弱性を標的とした前立腺がん治療法の探索. (2022)
  • Author(s): 河野晋, 曽我朋義,高橋智聡.
  • Organizer: 第8回がんと代謝研究会
  • Invited
• [Presentation] Pharmacologically targetable metabolic vulnerability in prostate cancer carrying RB1-SUCLA2 deletion. (2022)
  • Author(s): Takahashi C, Linn P, MishiroK, Kunishima M, Watanabe Y and Kohno S.
  • Organizer: Mechanisms & Models of Cancer, Cold Spring Harbor Laboratory Meetings
  • Int'l Joint Research
• [Presentation] A mutant p53 P72R driven modulation of CXCR5-CXCL13 axis in human B cell lymphoma migration. (2022)
  • Author(s): Gothwal KS, Kohno S, Sato A and Takahashi C.
  • Organizer: 18th International p53 Workshop
  • Int'l Joint Research
• [Presentation] RB欠損はERK経路の不活性化を介してMYCを不安定化させる. (2022)
  • Author(s): Gong 麟祥, Dominic Chih-Cheng Voon, 高橋智聡, 河野晋.
  • Organizer: 日本生化学会北陸支部 第40回大会
  • Int'l Joint Research
• [Presentation] Application of CDK4/6 inhibition therapies to PDACs. (2022)
  • Author(s): Zhang Y, Gothwal KS, Kohno S, Sheng J, Takahashi C.
  • Organizer: The 7th JCA-AACR Special Joint Conference
  • Int'l Joint Research
• [Presentation] PDACに対するCdk 4/6阻害療法の応用 (2022)
  • Author(s): 張園園, Gothwal KS, 河野晋, 盛金丹, 高橋智聡
  • Organizer: 第80回日本癌学会学術総会
  • Int'l Joint Research
• [Presentation] A mutant p53 P72R driven modulation of CXCR5-CXCL13 axis in human B cell lymphoma-migratio. (2022)
  • Author(s): Gothwal KS, Kohno S, Sato A and Takahashi C
  • Organizer: 第80回日本癌学会学術総会
  • Int'l Joint Research
• [Presentation] SUCLA2遺伝子欠失前立腺がんに対するthymoquinoneの治療効果 (2022)
  • Author(s): 河野晋, 高橋智聡
  • Organizer: 第66回香料・テルペンおよび精油化学に関する討論会
• [Presentation] Pharmacologically targetable metabolic vulnerability in prostate cancer carrying RB1-SUCLA2 deletion. (2021)
  • Author(s): Kohno S, Paing Linn, Soga T, Takahashi C.
  • Organizer: Keystone symposia tumor metabolism and microenvironment.
  • Int'l Joint Research
• [Presentation] Pharmacologically targetable vulnerability in prostate cancer carrying RB1-SUCLA2 loss. (2021)
  • Author(s): Kohno S, Paing Linn, Mishiro K, Kunishima M, Watanabe Y and Takahashi C
  • Organizer: AACR Annual Meeting 2021
  • Int'l Joint Research
• [Presentation] Treatment of RB1-intact cancers with CDK4/6 inhibitor combination therapy. (2021)
  • Author(s): Sheng J, Kohno S, Okada N, Ajioka I and Takahashi C.
  • Organizer: AACR Annual Meeting 2021
  • Int'l Joint Research
• [Presentation] Pharmacologically targetable vulnerability in prostate cancer carrying RB1-SUCLA2 deletion. (2021)
  • Author(s): Takahashi C.
  • Organizer: Cancer Science and Targeted Therapy Conference 2021
  • Int'l Joint Research
• [Presentation] RB1がん抑制遺伝子のステータスを標的とするがん治療. (2021)
  • Author(s): 高橋智聡, 盛金丹, 河野晋.
  • Organizer: 第80回日本癌学会学術総会
• [Presentation] CDK4/6 inhibitor combination therapy for the treatment of RB1-intact HCC. (2021)
  • Author(s): Sheng J, Kohno S, and Takahashi C.
  • Organizer: 第80回日本癌学会学術総会
• [Presentation] RB1-SUCLA2欠失による代謝脆弱性を標的とした前立腺がん治療法の開発. (2021)
  • Author(s): 河野晋, 高橋智聡.
  • Organizer: 第80回日本癌学会学術総会
• [Presentation] 合成CDK4/6阻害剤による肝細胞がん治療. (2021)
  • Author(s): 高橋智聡, 盛金丹, 河野晋.
  • Organizer: 第59回日本癌治療学会学術集会
• [Presentation] RB-コレステロールによる未分化性維持機構の解明 (2021)
  • Author(s): 9.河野晋, 佐々木信成, 高橋智聡.
  • Organizer: 第94回日本生化学大会
• [Presentation] 脂肪酸伸長酵素ELOVL6の阻害によるがん制御 (2020)
  • Author(s): 張智恒, 村中勇人, 友杉充宏, 河野晋, 高橋智聡
  • Organizer: 第14回スフィンゴテラピィ研究会
• [Presentation] RB1-SUCLA2欠損による代謝脆弱性を標的とした前立腺がん治療法の探索 (2020)
  • Author(s): 河野晋, Paing Linn, 曽我朋義, 高橋智聡
  • Organizer: 第79回日本癌学会学術総会
  • Int'l Joint Research
• [Presentation] NFYAによる糖新生促進が引き起こす腫瘍抑制効果の検討 (2020)
  • Author(s): 岡田宣宏, 辻本剛己, 吉川清次, 高橋智聡
  • Organizer: 第79回日本癌学会学術総会
  • Int'l Joint Research
• [Presentation] 進行前立腺がんにおけるRB1-SUCLA2遺伝子欠失を標的とする新規治療 (2020)
  • Author(s): 高橋智聡, Paing Linn, 曽我朋義, 河野晋
  • Organizer: 第58回日本癌治療学会学術総会
  • Int'l Joint Research
• [Presentation] キナーゼ阻害剤と組み合わせたCDK4/6阻害剤によるHCCの新しい併用療法 (2020)
  • Author(s): 盛金丹, 高橋智聡, 河野晋, 岡田宣宏
  • Organizer: 第43回日本分子生物学会年会
  • Int'l Joint Research
• [Presentation] 脂肪酸合成制御を介したNFYAによる乳がん悪性化機構への影響 (2020)
  • Author(s): 植木ちひろ、辻本剛己、河野晋、高橋智聡、岡田宣宏
  • Organizer: 第43回日本分子生物学会年会
  • Int'l Joint Research
• [Book] 別冊・医学のあゆみ『がん細胞社会における細胞間相互作用Which intercellular interaction should be targeted in cancer therapy?』 (2021)
  • Author(s): 高橋智聡, 河野晋.
  • Total Pages: 5
  • Publisher: 医歯薬出版株式会社
• [Remarks] 髙橋智聡研究室HP
  • URL: https://omb.w3.kanazawa-u.ac.jp/index.html
• [Remarks] 金沢大学がん進展制御研究所HP
  • URL: https://ganken.cri.kanazawa-u.ac.jp
• [Remarks] 髙橋智聡研究室ホームページ
  • URL: https://omb.w3.kanazawa-u.ac.jp
• [Remarks] 金沢大学がん進展制御研究所ホームページ
  • URL: http://ganken.cri.kanazawa-u.ac.jp
• [Remarks] 髙橋智聡研究室HP
  • URL: https://omb.w3.kanazawa-u.ac.jp
• [Remarks] 髙橋研究室HP
  • URL: https://omb.w3.kanazawa-u.ac.jp
• [Remarks] がん進展制御研究所HP
  • URL: http://ganken.cri.kanazawa-u.ac.jp
• [Patent(Industrial Property Rights)] ＲＢ１陽性癌の治療用医薬組成物及びキット (2020)
  • Inventor(s): 髙橋智聡、河野晋、盛金丹
  • Industrial Property Rights Holder: 髙橋智聡、河野晋、盛金丹
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2020-180429
  • Filing Date: 2020