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Study on vulnerability and predictive factors for neurodevelopmental disorders

Research Project

Project/Area Number 20H03595
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 52030:Psychiatry-related
Research InstitutionHirosaki University

Principal Investigator

Nakamura Kazuhiko  弘前大学, 医学研究科, 教授 (80263911)

Co-Investigator(Kenkyū-buntansha) 上野 伸哉  弘前大学, 医学研究科, 教授 (00312158)
斉藤 まなぶ  弘前大学, 保健学研究科, 教授 (40568846)
古川 智範  弘前大学, 医学研究科, 助教 (60402369)
下山 修司  弘前大学, 医学研究科, 助教 (60736370)
坂本 由唯  弘前大学, 医学部附属病院, 講師 (60770386)
足立 匡基  弘前大学, 保健学研究科, 准教授 (50637329)
高橋 芳雄  弘前大学, 保健学研究科, 准教授 (70760891)
Project Period (FY) 2020-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2022: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2021: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2020: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
Keywords神経発達症群 / 自閉症 / 注意欠如・多動症 / メタボローム解析 / 5歳児発達健診 / 神経発達障害 / 自閉スペクトラム症 / 注意欠如・多動性障害 / 質量分析
Outline of Research at the Start

①5歳児発達健診で神経発達障害の診断のついた約650名の5歳児を対象。1)ASD診断ツール、ADHD診断ツール、DCD診断ツールなどの各種ツールのデータ、2)メタボローム解析データ、エクソーム解析データ。これらのデータの変量解析を行い、新しい疾患概念の構築の可能性を明らかにする。
②約650名のデータと小学生1年生から6年生、中学生1年生から3年生の子どものこころのサポート調査の2014年から2019年の臨床データをリンクし、継時的な変化を解析し、神経発達障害から問題行動、各種精神疾患が発症しやすい脆弱性、予測因子を明らかにする。

Outline of Final Research Achievements

The 5-year-old developmental check-up was held annually in a certain city. We analyzed serum, genetic and other data of the neurodevelopmental disorder group for tenth years. Metabolomic analysis of plasma revealed that a group of amino acids had significant differences in ASD, and biogenic amines and fatty acids indicated significant differences in ADHD. Significant differences were found in four factors for the coexistence of ASD and ADHD. Furthermore, a correlation was found between sleep and ferritin in the neurodevelopmental disorder group, and a positive correlation was found between oxytocin levels and Conners' hyperactivity in girls in the ASD group.

Academic Significance and Societal Importance of the Research Achievements

2次発達健診で神経発達障害群の診断がついた5歳児約650名の血漿をメタボローム解析することでASD、ADHDの診断マーカーもしくは病態解明につながる因子がいくつか明らかになった。ASD、ADHDと睡眠やオキシトシン値との関連もわかり、ASDやADHDの病態解明につながる結果が得られたことは学問的意義があり、ASDとADHDは同じ群にあり、臨床的にそれを意識することは臨床的にも意義があり、社会に還元できる。

Report

(2 results)
  • 2023 Final Research Report ( PDF )
  • 2020 Annual Research Report
  • Research Products

    (23 results)

All 2020

All Journal Article (9 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 9 results,  Open Access: 9 results) Presentation (14 results) (of which Int'l Joint Research: 8 results)

  • [Journal Article] Prevalence and cumulative incidence of autism spectrum disorders and the patterns of co-occurring neurodevelopmental disorders in a total population sample of 5-year-old children2020

    • Author(s)
      Saito Manabu、Hirota Tomoya、Sakamoto Yui、Adachi Masaki、Takahashi Michio、Osato-Kaneda Ayako、Kim Young Shin、Leventhal Bennett、Shui Amy、Kato Sumi、Nakamura Kazuhiko
    • Journal Title

      Molecular Autism

      Volume: 11 Issue: 1 Pages: 35-35

    • DOI

      10.1186/s13229-020-00342-5

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] In vivo imaging of dopamine D1 receptor and activated microglia in attention-deficit/hyperactivity disorder: a positron emission tomography study2020

    • Author(s)
      Yokokura Masamichi、Takebasashi Kiyokazu、Takao Akiyo、Nakaizumi Kyoko、Yoshikawa Etsuji、Futatsubashi Masami、Suzuki Katsuaki、Nakamura Kazuhiko、Yamasue Hidenori、Ouchi Yasuomi
    • Journal Title

      Molecular Psychiatry

      Volume: - Issue: 9 Pages: 12-12

    • DOI

      10.1038/s41380-020-0784-7

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association between Sleep Disturbances and Emotional/Behavioral Problems in Chinese and Japanese Preschoolers.2020

    • Author(s)
      Wang G, Takahashi M, Wu R, Liu Z, Adachi M, Saito M, Nakamura, K, Jiang F.
    • Journal Title

      Behavioral Sleep Medicine

      Volume: 18(3) Issue: 3 Pages: 420-431

    • DOI

      10.1080/15402002.2019.1605995

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Utilization of the Maternal and Child Health Handbook in Early Identification of Autism Spectrum Disorder and Other Neurodevelopmental Disorders2020

    • Author(s)
      Hirota Tomoya、Bishop Somer、Adachi Masaki、Shui Amy、Takahashi Michio、Mori Hiroyuki、Nakamura Kazuhiko
    • Journal Title

      Autism Research

      Volume: 14 Issue: 3 Pages: 551-559

    • DOI

      10.1002/aur.2442

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Neurodevelopmental Traits and Longitudinal Transition Patterns in Internet Addiction: A 2-year Prospective Study2020

    • Author(s)
      Hirota Tomoya、Takahashi Michio、Adachi Masaki、Sakamoto Yui、Nakamura Kazuhiko
    • Journal Title

      Journal of Autism and Developmental Disorders

      Volume: 51 Issue: 4 Pages: 1365-1374

    • DOI

      10.1007/s10803-020-04620-2

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A potential role of fatty acid binding protein 4 in the pathophysiology of autism spectrum disorder.2020

    • Author(s)
      Maekawa M, Ohnishi T, Toyoshima M, Shimamoto-Mitsuyama C, Hamazaki K, Balan S, Wada Y, Esaki K, Takagai S, Tsuchiya KJ, Nakamura K, Iwata Y, Nara T, Iwayama Y, Toyota T, Nozaki Y, Ohba H, Watanabe A, Hisano Y, Matsuoka S, Tsujii M, Mori N, Matsuzaki H, Yoshikawa T.
    • Journal Title

      Brain Communication

      Volume: 2(2) Issue: 2

    • DOI

      10.1093/braincomms/fcaa145

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Concerns for labor analgesia and autism spectrum disorders2020

    • Author(s)
      Saito Manabu、Nakamura Kazuhiko、Hirota Kazuyoshi
    • Journal Title

      Journal of Anesthesia

      Volume: 35 Issue: 2 Pages: 319-320

    • DOI

      10.1007/s00540-020-02880-x

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Pediatric health-related quality of life and school social capital through network perspectives2020

    • Author(s)
      Hirota Tomoya、Takahashi Michio、Adachi Masaki、Nakamura Kazuhiko
    • Journal Title

      PLOS ONE

      Volume: 15 Issue: 12 Pages: e0242670-e0242670

    • DOI

      10.1371/journal.pone.0242670

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] VLDL-specific increases of fatty acids in autism spectrum disorder correlate with social interaction.2020

    • Author(s)
      Usui N, Toyoshima M et al.
    • Journal Title

      EBioMedicine

      Volume: 58 Pages: 102917-102917

    • DOI

      10.1016/j.ebiom.2020.102917

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Development of Screening Algorithm for Autism Spectrum Disorder in 5-Year-Old Children Using the Eye-Tracking Device (Gazefinder)2020

    • Author(s)
      Y. Sakamoto, M. Saito, M. Ninomiya, S. Hakoshima, K. J. Tsuchiya, A. Osato, A. Terui, H. Mori, K. Yoshida, Y. Matsubara, T. Mikami, M. Takahashi and K. Nakamura.
    • Organizer
      The International Society for Autism Research (INSAR) 2020 Annual Meeting
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of a Screening Algorithm of Neurodevelopmental Disorders for 5-Year-Old Children Toward Web Survey Systemization2020

    • Author(s)
      A. Terui, M. Saito, A. Osato, M. Tanaka, N. Takayanagi, M. Adachi, M. Wakuta, Y. Sakamoto, H. Mori, K. Yoshida, Y. Matsubara, T. Mikami, M. Takahashi, K. Nakamura and Y. Yamamura,
    • Organizer
      The International Society for Autism Research (INSAR) 2020 Annual Meeting
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Utilization of the Maternal and Child Health Handbook in Early Identification of Autism Spectrum Disorder and Other Neurodevelopmental Disorders.2020

    • Author(s)
      T Hirota, S. Bishop, M. Adachi, M. Takahashi, H. Mori, A. M. Shui and K. Nakamura
    • Organizer
      The International Society for Autism Research (INSAR) 2020 Annual Meeting
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] White Matter Structure Relates to Delayed Processing Speed for the Planning Task and in ASD without Intellectual Disability.2020

    • Author(s)
      M. Takahashi, Y. Matsubara and K. Nakamura.
    • Organizer
      The International Society for Autism Research (INSAR) 2020 Annual Meeting
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Creation of eye tracking pattern algorithm for 5 year old ASD screening.2020

    • Author(s)
      Saito Manabu, Ninomiya Masaru,Hakoshima Shuji, Tsuchiya Kenji, Osato Kaneda Ayako Mikami Tamaki, Sakamoto Yui , Yoshida Kazutaka , Terui Ai, Nakamura Kazuhiko.
    • Organizer
      NPBPPP2020 (第50回日本神経精神薬理学会年会・第42回日本生物学的精神医学会年会・第4回日本精神薬学会総会・学術集会 合同年会)
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 5歳児発達健診 Web スクリーニングシステム(ここあぽ)の完成2020

    • Author(s)
      斉藤 まなぶ、田中 勝則 、山村 靖彦 、和久田 学、大里 絢子、足立 匡基、三上 珠希 、 坂本 由唯 、照井 藍 、森 裕幸、新川 広樹 、高橋 芳雄、栗林 理人、中村 和彦
    • Organizer
      第116回日本精神神経学会学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Utilization of web screening system for developmental health check&-up in 5-yea-old children 5歳児発達健診でのWebスクリーニングシステムの活用2020

    • Author(s)
      斉藤まなぶ、田中勝則、大里絢子、足立匡基、坂本由唯、三上珠希、照井藍、鈴木裕幸、新川広樹、高橋芳雄、中村和彦
    • Organizer
      第62回日本小児神経学会学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 視点追跡装置(Gaze Finder)を用いた5歳児のASDスクリーニングアルゴリズムの開発2020

    • Author(s)
      斉藤まなぶ、坂本由唯、三上珠希、大里絢子、照井藍、中村和彦
    • Organizer
      第61回日本児童青年精神医学会総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 3歳児健診における簡便かつ鋭敏な神経発達症のスクリーニング法の探索2020

    • Author(s)
      大里 絢子, 斉藤 まなぶ, 坂本 由唯, 三上 珠希, 足立 匡基, 中村 和彦
    • Organizer
      第61回日本児童青年精神医学会総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 5歳児発達健診でのwebスクリーニングシステムの活用2020

    • Author(s)
      照井 藍, 斉藤 まなぶ, 田中 勝則, 大里 絢子, 足立 匡基, 坂本 由唯, 三上 珠希, 栗林 理人, 中村 和彦
    • Organizer
      第61回日本児童青年精神医学会総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 地域における5歳の自閉スペクトラム症の疫学調査 調整有病率と累積発生率2020

    • Author(s)
      斉藤 まなぶ, 坂本 由唯, 足立 匡基, 高橋 芳雄, 大里 絢子, 三上 珠希, 照井 藍, 栗林 理人, 中村 和彦
    • Organizer
      第61回日本児童青年精神医学会総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Prevalence of sleep problems in Japanese preschoolers and children with developmental disabilities.2020

    • Author(s)
      M Saito, M* Takahashi, A Terui, Y Sakamoto, M Adachi, H Shinkawa, H Mori, K Nakamura.
    • Organizer
      IACAPAP2020
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Comorbid rate of sleep problems and the characteristics in Japanese 5-yearold ASD children2020

    • Author(s)
      "Ai Terui*, Manabu Saito, Yui Sakamoto, Tomoya Hirota , Michio Takahashi, Tamaki Mikami, Hiroki Shinkawa, Kazuhiko Nakamura"
    • Organizer
      IACAPAP2020
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] "Plasma Oxytocin and Developmental Disorders in Japanese 5-year-old children"2020

    • Author(s)
      "Yui Sakamoto*, Manabu Saito, Shuji Shimoyama, Ayako Osato, Ai Terui, Kazutaka Yoshida, Tamaki Mikami, Kazuhiko Nakamura"
    • Organizer
      IACAPAP2020
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research

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Published: 2020-04-28   Modified: 2025-01-30  

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