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Elucidation of the brain pathology of mental disorders based on the understanding of the process of internalization of social structure into individual mental and brain functions

Research Project

Project/Area Number 20H03596
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 52030:Psychiatry-related
Research InstitutionThe University of Tokyo

Principal Investigator

Kasai Kiyoto  東京大学, 医学部附属病院, 教授 (80322056)

Project Period (FY) 2020-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2022: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2021: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2020: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
Keywords社会構造 / トラウマ / 思春期 / 脳画像 / 精神疾患 / 脳機能
Outline of Research at the Start

本研究はAdolescent and young adults [AYA]世代における社会構造という抽象化されたルール構造の個体の精神・脳機能への内在化(内面化)の影響を精神疾患患者コホートと健常思春期コホートを相補的に用いて明らかにする。近年AYA世代における社会構造ストレスが精神疾患の発症リスクを高めるとのエビデンスが得られつつある。しかしながら、個人が曝露されている社会構造を定量化したうえで脳画像解析と組み合わせ、精神疾患患者群と健常思春期のpopulation-based cohortを相補的に活用し、かつ縦断で因果関係を示した研究はまだないため、国際的にきわめて先駆性が高い。

Outline of Final Research Achievements

The aim of this study was to elucidate the internalizing effects of the social environment on individual mental and brain functioning in adolescents and young adults [AYA] using complementary data from individuals with psychiatric disorders and healthy controls including adolescents recruited from a population-based cohort. To this end, we quantified the traumas (adverse childhood experiences [ACEs]) and social structures to which individuals are exposed and combined them with brain imaging analysis (MRI, near-infrared spectroscopy). The results suggest that trauma and social structure may influence brain morphology and function. It was also suggested that the presence of a help-seeking attitude may mitigate the effects of trauma on brain functional development.

Academic Significance and Societal Importance of the Research Achievements

従来型の精神疾患の脳病態研究は、遺伝的素因(G)と周産期の環境要因(E1)の相互作用影響をモデル化してきたが、不適切な養育態度など児童期の親子関係(E2)や、AYA世代までの都市居住・マイノリティ状況などの社会環境ストレス(E3)が、精神疾患の発症を含む思春期の脳発達に与える影響はほとんど解明されてこなかった。本研究は、トラウマや社会構造が脳形態・機能に影響を与える可能性を示唆するとともに、援助希求態度があることが、トラウマが脳機能に与える影響を緩和する可能性を明らかにしたことで、高い学術的意義を持つとともに、思春期精神保健施策上も重要な社会的意義を持つと考えられた。

Report

(4 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Annual Research Report
  • 2020 Annual Research Report
  • Research Products

    (30 results)

All 2023 2022 2021 2020 Other

All Int'l Joint Research (3 results) Journal Article (14 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 14 results,  Open Access: 13 results) Presentation (10 results) (of which Int'l Joint Research: 2 results,  Invited: 8 results) Book (1 results) Remarks (2 results)

  • [Int'l Joint Research] Fordham University/UC Irvine(米国)

    • Related Report
      2022 Annual Research Report
  • [Int'l Joint Research] Fordham University(米国)

    • Related Report
      2021 Annual Research Report
  • [Int'l Joint Research] University of Pittsburgh/University of California, San Francisco/Rush University Medical Center(米国)

    • Related Report
      2020 Annual Research Report
  • [Journal Article] Attributes of auditory hallucinations associated with self-harm: a prospective cohort study2023

    • Author(s)
      DeVylder J, Yamasaki S, Ando S, Miyashita M, Endo ., Baba K, Niimura J, Nakajima N, Yamaguchi S, Stanyon D, Narita Z, Schiffman J, Hiraiwa-Hasegawa M, Kasai K, Nishida A
    • Journal Title

      Schizophr Res

      Volume: 251 Pages: 30-36

    • DOI

      10.1016/j.schres.2022.12.008

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Structural brain abnormalities in schizophrenia patients with a history and presence of auditory verbal hallucination2022

    • Author(s)
      Sone M, Koshiyama D, Zhu Y, Maikusa N, Okada N, Yamasue H, Abe O, Kasai K, Koike S
    • Journal Title

      Transl Psychiatry

      Volume: 12 Issue: 1 Pages: 511-511

    • DOI

      10.1038/s41398-022-02282-5

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Retrospective chart review‐based assessment scale for adverse childhood events and experiences2022

    • Author(s)
      Yamagishi Mika、Satomura Yoshihiro、Sakurada Hanako、Kanehara Akiko、Sakakibara Eisuke、Okada Naohiro、Koike Shinsuke、Yagishita Sho、Ichihashi Kayo、Kondo Shinsuke、Jinde Seiichiro、Fukuda Masato、Kasai Kiyoto
    • Journal Title

      Psychiatry and Clinical Neurosciences Reports

      Volume: 1 Issue: 4

    • DOI

      10.1002/pcn5.58

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Maternal parenting stress from birth to 36months, maternal depressive symptoms, and physical punishment to 10-year-old children: a population-based birth cohort study2022

    • Author(s)
      Niimura Junko、Nakanishi Miharu、Yamasaki Syudo、Ando Shuntaro、Kanata Sho、Fujikawa Shinya、Morimoto Yuko、Endo Kaori、Hiraiwa-Hasegawa Mariko、Kasai Kiyoto、Nishida Atsushi
    • Journal Title

      Social Psychiatry and Psychiatric Epidemiology

      Volume: 57 Issue: 11 Pages: 2207

    • DOI

      10.1007/s00127-022-02319-6

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Implementation of online classes during national school closure due to COVID-19 and mental health symptoms of adolescents:A cross-sectional survey of 5,000 students2022

    • Author(s)
      Morishima R, Koike H, Kanehara A, Usui K, Okada N, Ando S, Kasai K.
    • Journal Title

      Psychiatry and Clinical Neurosciences Reports

      Volume: accept Issue: 2

    • DOI

      10.1002/pcn5.17

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] “World-Informed” Neuroscience for Diversity and Inclusion: An Organizational Change in Cognitive Sciences2022

    • Author(s)
      Kasai K, Kumagaya SI, Takahashi Y, Sawai Y, Uno A, Kumakura Y, Yamagishi M, Kanehara A, Morita K, Tada M, Satomura Y, Okada N, Koike S, Yagishita S.
    • Journal Title

      Clin EEG Neurosci

      Volume: Online ahead of print Issue: 6 Pages: 560-566

    • DOI

      10.1177/15500594221105755

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Personalized values in life as point of interaction with the world: Developmental/neurobehavioral basis and implications for psychiatry2022

    • Author(s)
      Kasai K, Yagishita S, Tanaka SC, Koike S, Murai T, Nishida A, Yamasaki S, Ando S, Kawakami N, Kanehara A, Morita K, Kumakura Y, Takahashi Y, Sawai Y, Uno A, Sakakibara E, Okada N, Okamoto Y, Nochi M, Kumagaya SI, Fukuda M
    • Journal Title

      Psychiatry Clin Neurosci Rep

      Volume: 1 Issue: 2

    • DOI

      10.1002/pcn5.12

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Culture-dependent and Universal Constructs and Promoting Factors for the Process of Personal Recovery in users of Mental Health Services: Qualitative Findings from Japan.2022

    • Author(s)
      Kanehara A, Koike H, Fujieda Y, Yajima S, Kabumoto A, Kumakura Y, Morita K, Miyamoto Y, Nochi M, Kasai K
    • Journal Title

      BMC Psychiatry

      Volume: 10;22(1) Pages: 105-105

    • DOI

      10.21203/rs.3.rs-258956/v1

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Trajectory and course of problematic alcohol use after the Great East Japan Earthquake: Eight‐year follow‐up of the Higashi‐Matsushima cohort study2022

    • Author(s)
      Morishima Ryo、Usami Satoshi、Ando Shuntaro、Kiyono Tomoki、Morita Masaya、Fujikawa Shinya、Araki Tsuyoshi、Kasai Kiyoto
    • Journal Title

      Alcoholism: Clinical and Experimental Research

      Volume: 46 Issue: 4 Pages: 570-580

    • DOI

      10.1111/acer.14787

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Migration and psychotic experiences in the Tokyo Teen Cohort2022

    • Author(s)
      DeVylder Jordan、Endo Kaori、Yamasaki Syudo、Ando Shuntaro、Hiraiwa-Hasegawa Mariko、Kasai Kiyoto、Nishida Atsushi
    • Journal Title

      Journal of Migration and Health

      Volume: 5 Pages: 100078-100078

    • DOI

      10.1016/j.jmh.2022.100078

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Criticality in the Healthy Brain2022

    • Author(s)
      Shi Jifan、Kirihara Kenji、Tada Mariko、Fujioka Mao、Usui Kaori、Koshiyama Daisuke、Araki Tsuyoshi、Chen Luonan、Kasai Kiyoto、Aihara Kazuyuki
    • Journal Title

      Frontiers in Network Physiology

      Volume: 1 Pages: 1-9

    • DOI

      10.3389/fnetp.2021.755685

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A 2-year longitudinal follow-up of quantitative assessment neck tics in Tourette’s syndrome2021

    • Author(s)
      Eriguchi Yosuke、Gu Xiaoxue、Aoki Naoto、Nonaka Maiko、Goto Ryunosuke、Kuwabara Hitoshi、Kano Yukiko、Kasai Kiyoto
    • Journal Title

      PLOS ONE

      Volume: 16 Issue: 12 December Pages: 261560-261560

    • DOI

      10.1371/journal.pone.0261560

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association of Structural Magnetic Resonance Imaging Measures With Psychosis Onset in Individuals at Clinical High Risk for Developing Psychosis2021

    • Author(s)
      ENIGMA Clinical High Risk for Psychosis Working Group
    • Journal Title

      JAMA Psychiatry

      Volume: online Issue: 7 Pages: 753-753

    • DOI

      10.1001/jamapsychiatry.2021.0638

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Abnormality of Resting-State Functional Connectivity in Major Depressive Disorder: A Study With Whole-Head Near-Infrared Spectroscopy2021

    • Author(s)
      Sakakibara Eisuke、Satomura Yoshihiro、Matsuoka Jun、Koike Shinsuke、Okada Naohiro、Sakurada Hanako、Yamagishi Mika、Kawakami Norito、Kasai Kiyoto
    • Journal Title

      Frontiers in Psychiatry

      Volume: 12 Pages: 664859-664859

    • DOI

      10.3389/fpsyt.2021.664859

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Tojisha-oriented psychiatry in Japan2022

    • Author(s)
      Kasai K
    • Organizer
      Decolonizing Mental Health in Asia
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 新型コロナウイルス感染症対策としての全国一斉臨時休校期間中のオンライン授業実施と思春期メンタルヘルス:5000名の中学生・高校生対象の横断調査.2022

    • Author(s)
      森島遼、小池春奈、金原明子、臼井香、岡田直大、安藤俊太郎、笠井清登
    • Organizer
      第25回日本精神保健・予防学会学術集会、京都
    • Related Report
      2022 Annual Research Report
  • [Presentation] 「統合失調症の病態解明研究」の目的と方法の再設定.2022

    • Author(s)
      笠井清登
    • Organizer
      BPCNPNPPP4学会合同年会、東京、教育講演
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] だいじょうぶな社会にむけた一歩.2022

    • Author(s)
      笠井清登
    • Organizer
      リカバリー全国フォーラム2022、オンライン
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 社会神経科学の社会論的転回2022

    • Author(s)
      笠井清登
    • Organizer
      2022年度生理研研究会 第12回社会神経科学研究会「社会神経科学研究の今後の展開に向けて」オンライン
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 精神と行動の科学2022

    • Author(s)
      笠井清登
    • Organizer
      第46回群馬精神医学会生涯教育研修会、群馬大学、講演
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 人生行動科学としての思春期学2022

    • Author(s)
      笠井清登
    • Organizer
      第41回日本思春期学会総会・学術集会、つくば国際会議場+オンライン開催、教育講演
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 思春期青年期に対する、価値ということに自覚的になるケア(values-informed care).2022

    • Author(s)
      笠井清登
    • Organizer
      日本思春期青年期精神医学会第34回大会、東京、特別講演
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 精神疾患の男女別発症率の経時変化と、都市化との相関の解析2021

    • Author(s)
      澤井大和、宇野晃人、高橋優輔、柳下祥、笠井清登
    • Organizer
      第24回日本精神保健・予防学会
    • Related Report
      2021 Annual Research Report
  • [Presentation] “Translatable” neurophysiological & neuroanatomical markers to understand pathophysiology of psychosis onset in adolescence.2020

    • Author(s)
      Kiyoto Kasai
    • Organizer
      The 5th Japan-US Science Forum in Boston (virtual). November 15, 2020.
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research / Invited
  • [Book] 女性のこころの臨床を学ぶ・語る2022

    • Author(s)
      笠井さつき、笠井清登
    • Total Pages
      243
    • Publisher
      金剛出版
    • ISBN
      9784772419383
    • Related Report
      2022 Annual Research Report
  • [Remarks] WINDI lab home page

    • URL

      http://windilab.net

    • Related Report
      2022 Annual Research Report
  • [Remarks] 東大精神科ホームページ

    • URL

      http://npsy.umin.jp/

    • Related Report
      2020 Annual Research Report

URL: 

Published: 2020-04-28   Modified: 2024-01-30  

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