| Budget Amount *help |
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2022: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2021: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2020: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
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| Outline of Final Research Achievements |
The C9orf72 repeat expansion mutation is a major causative genetic mutation in familial frontotemporal lobar degeneration (frontotemporal dementia) and amyotrophic lateral sclerosis. We have previously found that the pathogenic GGGGCC repeat RNA-binding protein hnRNPA3 promotes repeat RNA metabolism, but the mechanism is unknown. In this study, we used a combination of proximal biotinylation and mass spectrometry to comprehensively delineate the neighbourhood of hnRNPA3 and identify a promising novel factor involved in GGGGCC repeat RNA metabolism.
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