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治療抵抗性うつ病に対するMAOーB PET研究

Research Project

Project/Area Number 20H03606
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 52030:Psychiatry-related
Research InstitutionKeio University

Principal Investigator

森口 翔  慶應義塾大学, 医学部(信濃町), 共同研究員 (40594776)

Co-Investigator(Kenkyū-buntansha) 高畑 圭輔  国立研究開発法人量子科学技術研究開発機構, 量子医科学研究所 脳機能イメージング研究部, 研究員 (20645311)
中島 振一郎  慶應義塾大学, 医学部(信濃町), 講師 (60383866)
三村 將  慶應義塾大学, 医学部(信濃町), 特任教授 (00190728)
Project Period (FY) 2020-04-01 – 2024-03-31
Project Status Granted (Fiscal Year 2023)
Budget Amount *help
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2023: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2022: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2021: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2020: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Keywordsうつ病 / PET / MAO-B / [11C] SL2511.88 / 治療抵抗性うつ病 / MAOーB / ポジトロン断層撮影
Outline of Research at the Start

うつ病の薬物療法の中心はモノアミン再取り込み阻害薬だが、約30%から50%の患者は反応せず治療抵抗性(treatment-resistant depression: TRD)である。TRDの病態生理は未だ解明されておらず、モノアミン酸化酵素B (MAO-B)の異常が提唱されている。本研究においてMAO-B PETを導入し、低浸襲で行える定量法を検証する。さらに脳内MAO-B密度をTRD、寛解患者、健常人の各20名において測定し、TRDにおいてより特異的に脳内MAO-B密度が上昇しているかを評価することを目的とする。本研究を通して、脳内MAO-B密度とTRDとの関連を検証する。

Outline of Annual Research Achievements

当初よりスムーズにリクルートは進んでいる。現在慶應義塾大学病院のみではなく、関連病院の協力を得て、比較的被験者のリクルートを進められている。
現時点で、本研究の検査であるPET検査やマルチモーダルMRIに関する有 害事象、実施計画書からの逸脱は認められていない。また脱落例も認められていなく、本研究 における研究全体の基本的な手順は遵守されていると判断する。 予備解析では、患者群で一部の脳部位でMAOB結合能の若干の増加を認めた。今後、被験者を最終目標まで増やし、解析も行なっていく。

Current Status of Research Progress
Current Status of Research Progress

3: Progress in research has been slightly delayed.

Reason

本実験に被験者として必要となる研究協力者のうち健常者がコロナの既感染であることが判明し、MAOB結合脳への影響が懸念され必要なサンプル数が確保できなくなった。現在、健常者のリクルートを中心に進めている。

Strategy for Future Research Activity

これまで通り、健常群を中心に被験者の組み入れを進め、臨床評価、PET撮像、MRI撮像、採血を行っていく。うつ病患者群、健常群の計測と解析を進め、それぞれの群間比較を行う予定である。PETのMAOB結合能のみではなく、MRIデータについてもそれぞれの群で解析し、群間比較およびこれらの関係について解析する予定である。

Report

(3 results)
  • 2022 Annual Research Report
  • 2021 Annual Research Report
  • 2020 Annual Research Report
  • Research Products

    (20 results)

All 2023 2022 2021 2020 Other

All Int'l Joint Research (2 results) Journal Article (16 results) (of which Int'l Joint Research: 11 results,  Peer Reviewed: 16 results,  Open Access: 8 results) Presentation (2 results) (of which Invited: 2 results)

  • [Int'l Joint Research] トロント大学(カナダ)

    • Related Report
      2022 Annual Research Report
  • [Int'l Joint Research] トロント大学(カナダ)

    • Related Report
      2021 Annual Research Report
  • [Journal Article] Performance of plasma Aβ42/40, measured using a fully automated immunoassay, across a broad patient population in identifying amyloid status2023

    • Author(s)
      Bun Shogyoku、Ito Daisuke、Tezuka Toshiki、Kubota Masahito、Ueda Ryo、Takahata Keisuke、Moriguchi Sho、Kurose Shin、Momota Yuki、Suzuki Natsumi、Morimoto Ayaka、Hoshino Yuka、Seki Morinobu、Mimura Yu、Shikimoto Ryo、Yamamoto Yasuharu、Hoshino Takayuki、Sato Yoshiaki、Tabuchi Hajime、Mimura Masaru
    • Journal Title

      Alzheimer's Research & Therapy

      Volume: 15 Issue: 1 Pages: 149-149

    • DOI

      10.1186/s13195-023-01296-5

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] COVID-19, young people, and suicidal behaviour2023

    • Author(s)
      Horita Nobuyuki、Moriguchi Sho
    • Journal Title

      The Lancet Psychiatry

      Volume: 10 Issue: 7 Pages: 484-485

    • DOI

      10.1016/s2215-0366(23)00159-1

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Astrogliosis marker 11C-SL25.1188 PET in traumatic brain injury with persistent symptoms2023

    • Author(s)
      Koshimori Yuko、Cusimano Michael D、Vieira Erica L、Rusjan Pablo M、Kish Stephen J、Vasdev Neil、Moriguchi Sho、Boileau Isabelle、Chao Thomas、Nasser Zahra、Ishrat Husain M、Faiz Khunsa、Braga Joeffre、Meyer Jeffrey H
    • Journal Title

      Brain

      Volume: 146 Issue: 11 Pages: 4469-4475

    • DOI

      10.1093/brain/awad279

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Serotonergic Neurotransmission in Limbic Regions May Reflect Therapeutic Response of Depressive Patients: A PET Study With 11C-WAY-100635 and 18F-MPPF2023

    • Author(s)
      Kitamura Soichiro、Kimura Yasuyuki、Takahata Keisuke、Moriguchi Sho、Kubota Manabu、Shimada Hitoshi、Endo Hironobu、Takado Yuhei、Kawamura Kazunori、Zhang Ming-Rong、Suhara Tetsuya、Higuchi Makoto
    • Journal Title

      International Journal of Neuropsychopharmacology

      Volume: 26 Issue: 7 Pages: 474-482

    • DOI

      10.1093/ijnp/pyad026

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Association of protein distribution and gene expression revealed by positron emission tomography and postmortem gene expression in the dopaminergic system of the human brain2023

    • Author(s)
      Yamamoto Yasuharu、Takahata Keisuke、Kubota Manabu、Takeuchi Hiroyoshi、Moriguchi Sho、Sasaki Takeshi、Seki Chie、Endo Hironobu、Matsuoka Kiwamu、Tagai Kenji、Kimura Yasuyuki、Kurose Shin、Mimura Masaru、Kawamura Kazunori、Zhang Ming-Rong、Higuchi Makoto
    • Journal Title

      European Journal of Nuclear Medicine and Molecular Imaging

      Volume: 50 Issue: 13 Pages: 3928-3936

    • DOI

      10.1007/s00259-023-06390-2

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Glutamatergic Neurometabolite Levels in Bipolar Disorder: A Systematic Review and Meta-analysis of Proton Magnetic Resonance Spectroscopy Studies2023

    • Author(s)
      Ino H, Honda S, Yamada K, Horita N, Tsugawa S, Yoshida K, Noda Y, Meyer JH, Mimura M, Nakajima S, Moriguchi S.
    • Journal Title

      Biological Psychiatry: Cognitive Neuroscience and Neuroimaging

      Volume: 8 Issue: 2 Pages: 140-150

    • DOI

      10.1016/j.bpsc.2022.09.017

    • Related Report
      2022 Annual Research Report 2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Neuromelanin accumulation in patients with schizophrenia: A systematic review and meta-analysis2022

    • Author(s)
      Ueno Fumihiko、Iwata Yusuke、Nakajima Shinichiro、Caravaggio Fernando、Rubio Jose M.、Horga Guillermo、Cassidy Clifford M.、Torres-Carmona Edgardo、de Luca Vincenzo、Tsugawa Sakiko、Honda Shiori、Moriguchi Sho、Noda Yoshihiro、Gerretsen Philip、Graff-Guerrero Ariel
    • Journal Title

      Neuroscience and Biobehavioral Reviews

      Volume: 132 Pages: 1205-1213

    • DOI

      10.1016/j.neubiorev.2021.10.028

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Trends in Suicide in Japan Following the 2019 Coronavirus Pandemic2022

    • Author(s)
      Horita Nobuyuki、Moriguchi Sho
    • Journal Title

      JAMA Network Open

      Volume: 5 Issue: 3 Pages: e224739-e224739

    • DOI

      10.1001/jamanetworkopen.2022.4739

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Publication rates in English of abstracts presented at the annual meeting of the Japanese Society of Psychiatry and Neurology2022

    • Author(s)
      Yoshida Kazunari、Moriguchi Sho、Koda Masahide、Oka Takuya、Ueno Fumihiko、Ikai‐Tani Saeko、Tani Hideaki、Mimura Masaru
    • Journal Title

      Psychiatry and Clinical Neurosciences

      Volume: 76 Issue: 6 Pages: 206-211

    • DOI

      10.1111/pcn.13351

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Findings of (18) F-PI-2620 tau PET imaging in patients with Alzheimer's disease and healthy controls in relation to the plasma P-tau181 levels in a Japanese sample2022

    • Author(s)
      Bun S, Moriguchi S, Tezuka T, Sato Y, Takahata K, Seki M, Nakajima S, Yamamoto Y, Sano Y, Suzuki N, Morimoto A, Ueda R, Tabuchi H, Ito D, Mimura M.
    • Journal Title

      Neuropsychopharmacology Reports

      Volume: 42 Issue: 4 Pages: 437-448

    • DOI

      10.1002/npr2.12281

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Glutamatergic and GABAergic metabolite levels in schizophrenia-spectrum disorders: a meta-analysis of 1H-magnetic resonance spectroscopy studies2021

    • Author(s)
      Nakahara T, Tsugawa S, Noda Y, Ueno F, Honda S, Kinjo M, Segawa H, Hondo N, Mori Y, Watanabe H, Nakahara K, Yoshida K, Wada M, Tarumi R, Iwata Y, Plitman E, Moriguchi S, de la Fuente-Sandoval C, Nakajima S.
    • Journal Title

      Molecular Psychiatry

      Volume: 27 Issue: 1 Pages: 744-757

    • DOI

      10.1038/s41380-021-01297-6

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Excess tau PET ligand retention in elderly patients with major depressive disorder2020

    • Author(s)
      Moriguchi Sho、Takahata Keisuke、Shimada Hitoshi、Kubota Manabu、Kitamura Soichiro、Kimura Yasuyuki、Tagai Kenji、Tarumi Ryosuke、Tabuchi Hajime、Meyer Jeffrey H.、Mimura Masaru、Kawamura Kazunori、Zhang Ming-Rong、Murayama Shigeo、Suhara Tetsuya、Higuchi Makoto
    • Journal Title

      Molecular Psychiatry

      Volume: Online ahead of print Issue: 10 Pages: 5856-5863

    • DOI

      10.1038/s41380-020-0766-9

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Treatment effects on neurometabolite levels in schizophrenia: A systematic review and meta-analysis of proton magnetic resonance spectroscopy studies.2020

    • Author(s)
      Manabu Kubota, Sho Moriguchi, Keisuke Takahata, Shinichiro Nakajima, Nobuyuki Horita
    • Journal Title

      Schizophrenia Research

      Volume: - Pages: 122-132

    • DOI

      10.1016/j.schres.2020.03.069

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Primary functional brain connections associated with melancholic major depressive disorder and modulation by antidepressants2020

    • Author(s)
      Ichikawa Naho、Lisi Giuseppe、Yahata Noriaki、Okada Go、Takamura Masahiro、Hashimoto Ryu-ichiro、Yamada Takashi、Yamada Makiko、Suhara Tetsuya、Moriguchi Sho、Mimura Masaru、Yoshihara Yujiro、Takahashi Hidehiko、Kasai Kiyoto、Kato Nobumasa、Yamawaki Shigeto、Seymour Ben、Kawato Mitsuo、Morimoto Jun、Okamoto Yasumasa
    • Journal Title

      Scientific Reports

      Volume: 10 Issue: 1 Pages: 3542-3542

    • DOI

      10.1038/s41598-020-60527-z

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Treatment effects on neurometabolite levels in schizophrenia: A meta-analysis dataset of proton magnetic resonance spectroscopy2020

    • Author(s)
      Kubota Manabu、Moriguchi Sho、Takahata Keisuke、Nakajima Shinichiro、Horita Nobuyuki
    • Journal Title

      Data in Brief

      Volume: 31 Pages: 105862-105862

    • DOI

      10.1016/j.dib.2020.105862

    • NAID

      120006956392

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Publisher Correction: Primary functional brain connections associated with melancholic major depressive disorder and modulation by antidepressants2020

    • Author(s)
      Ichikawa Naho、Lisi Giuseppe、Yahata Noriaki、Okada Go、Takamura Masahiro、Hashimoto Ryu-ichiro、Yamada Takashi、Yamada Makiko、Suhara Tetsuya、Moriguchi Sho、Mimura Masaru、Yoshihara Yujiro、Takahashi Hidehiko、Kasai Kiyoto、Kato Nobumasa、Yamawaki Shigeto、Seymour Ben、Kawato Mitsuo、Morimoto Jun、Okamoto Yasumasa
    • Journal Title

      Scientific Reports

      Volume: 10 Issue: 1 Pages: 17650-17650

    • DOI

      10.1038/s41598-020-73436-y

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] うつ大会企画シンポジウム2「気分障害と神経変性疾患」2022

    • Author(s)
      森口翔
    • Organizer
      第19 回日本うつ病学会総会・第5回日本うつ病リワーク協会年次大会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 下田光造賞受賞講演2022

    • Author(s)
      森口翔
    • Organizer
      第19 回日本うつ病学会総会・第5回日本うつ病リワーク協会年次大会
    • Related Report
      2021 Annual Research Report
    • Invited

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Published: 2020-04-28   Modified: 2024-12-25  

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