| Budget Amount *help |
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2022: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2021: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2020: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
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| Outline of Final Research Achievements |
In this study, we molecularly examined the proliferation and expansion of gastric cancer-originating cells and the progression of cancer cells using mouse models and omics-analysis including single-cell level analysis and spatial analysis. Lineage tracing experiments revealed that epithelial stem cells are the main source of gastric cancer, and that dedifferentiation from mature differentiated cells such as chief cells hardly contributes to gastric cancer. Genetically engineered mice and single cell analysis showed that Rspo3/Lgr4 signals are important for proliferation and differentiation of stem cells. Investigation of a genetically modified model that develops gastric cancer revealed that gene mutations in tumor cells lead to high expression of characteristic molecules, which in turn causes remodeling of the surrounding microenvironment.
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