Analysis of pathophysiology in the setting of IBD

• Project/Area Number: 20H03658
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Review Section: Basic Section 53010:Gastroenterology-related
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: NAGAISHI Takashi 東京医科歯科大学, 大学院医歯学総合研究科, 寄附講座准教授 (60447464)
• Co-Investigator(Kenkyū-buntansha): 長堀 正和 東京医科歯科大学, 東京医科歯科大学病院, 准教授 (60420254)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Project Status: Completed (Fiscal Year 2022)
• Budget Amount: ¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000); Fiscal Year 2022: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2021: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000); Fiscal Year 2020: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
• Keywords: 免疫学 / 腸管免疫 / 消化器病学 / 炎症性腸疾患

Outline of Research at the Start

我々はこれまでの研究結果をもとに、本研究計画ではIBDモデルの発症過程を詳細に解析する。本研究は「腸管粘膜の免疫恒常性はGALTにおける免疫寛容の誘導によって制御され、その異常がIBDの本態となる」という概念に着目しつつ、新規バイオセンサーおよび生体イメージング技術等、我々が独自に樹立している技術を融合し、得られる成果からはこれまで理解し得なかったGALTにおける新規免疫応答が見出される。またIBDの発症や永続性といった病態メカニズムの理解が可能となり、最終的にIBDの特異的病態に対する新規診断・治療法開発の基盤を創出するものと期待される。

Outline of Final Research Achievements

Inflammatory bowel disease (IBD), including Crohn’s disease and ulcerative colitis, is characterized by unrestrained lymphocyte activation that results in the production of a variety of pro-inflammatory cytokines and other mediators. Understanding the mechanisms of lymphocyte activation is critical in the study of dysregulated mucosal inflammation such as IBD. In this regard, we have recently established an intravital imaging system to investigate several murine models of IBD, such as DSS colitis and oxazolone colitis. Associated with this, we were able to observe in vivo activities where functions of effecter lymphocytes can be activated in several IBD models. Defining the physiological mechanisms of unrestrained lymphocyte activation will lead to a greater understanding of how manipulation of effecter lymphocyte function may provide insights into novel treatment of IBD.

Academic Significance and Societal Importance of the Research Achievements

炎症性腸疾患(IBD)の新規治療法開発を困難にしている理由は、腸管の免疫調節機構が未だ不明確なことにある。本研究の意義は腸管の粘膜免疫応答に関する研究を独自に展開してきた申請者らが、ライブイメージング技術、FRET技術、および遺伝子導入系等といった、これまでの技術と知見を統合しつつ腸管特有の免疫調節機構を繙くことで、これまでベールに包まれていた「GALT内抗原提示細胞の新たな調節機構」の解明に向けた技術基盤を樹立するという免疫学的貢献ばかりでなく、IBDの発症時におけるその変調に対して極めて病態特異性の高い新規診断・治療法開発の理論基盤の創出に発展するものと期待できる。

Research Products

• [Int'l Joint Research] Brigham and Women's Hospital/Harvard Medical School(米国)
• [Int'l Joint Research] University of British Columbia(カナダ)
• [Int'l Joint Research] Brigham and Women's Hospital/Harvard Medical School(米国)
• [Int'l Joint Research] Imperial College London(英国)
• [Journal Article] Apelin expression is downregulated in T cells in a murine model of chronic colitis (2023)
  • Author(s): Yamada D、Kojima Yi、Hosoya A、Suzuki、Watabe T、Inoue T、Tsugawa N、Asakawa T、Yonemoto Y、Onizawa M、Nemoto Y、Oshima S、Shimonaka M、Kuba Ki、Ishida J、Fukamizu A、Penninger JM、Watanabe M、Okamoto R、Nagaishi T
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 647 Pages: 72-79
  • DOI: 10.1016/j.bbrc.2023.01.068
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] 今月の主題 炎症性腸疾患の粘膜治癒を再考する 主題 Crohn病における小腸粘膜治癒評価の意義-バルーン内視鏡の立場から (2022)
  • Author(s): 大塚 和朗, 竹中 健人, 齊藤 詠子, 日比谷 秀爾, 河本 亜美, 森川 亮, 藤井 俊光, 清水 寛路, 長堀 正和, 岡本 隆一
  • Journal Title: 胃と腸 Volume: 57 Issue: 2 Pages: 173-181
  • DOI: 10.11477/mf.1403202659
  • ISSN: 0536-2180, 1882-1219
  • Year and Date: 2022-02-25
• [Journal Article] Zranb1-mutant mice display abnormal colonic mucus production and exacerbation of DSS-induced colitis. (2022)
  • Author(s): Tamura A, Ito G, Matsuda H, Nibe-Shirakihara Y, Hiraoka Y, Kitagawa S, Hiraguri Y, Nagata S, Aonuma E, Otsubo K, Nemoto Y, Nagaishi T, Watanabe M, Okamoto R, Oshima S.
  • Journal Title: Biochem Biophys Res Commun. Volume: 628 Pages: 147-154
  • DOI: 10.1016/j.bbrc.2022.08.046
  • Peer Reviewed
• [Journal Article] Deep neural network for video colonoscopy of ulcerative colitis: a cross-sectional study (2022)
  • Author(s): Kento Takenaka, Toshimitsu Fujii, Ami Kawamoto, Kohei Suzuki, Hiromichi Shimizu, Chiaki Maeyashiki, Osamu Yamaji, Maiko Motobayashi, Akira Igarashi, Ryoichi Hanazawa, Shuji Hibiya, Masakazu Nagahori, Eiko Saito, Ryuichi Okamoto, Kazuo Ohtsuka, Mamoru Watanabe
  • Journal Title: Lancet Gastroenterol Hepatol Volume: 7 Issue: 3 Pages: 230-237
  • DOI: 10.1016/s2468-1253(21)00372-1
  • Peer Reviewed / Open Access
• [Journal Article] Mucosal healing of small intestinal stricture is associated with improved prognosis post-dilation in Crohn's disease (2022)
  • Author(s): Shuji Hibiya, Kazuo Ohtsuka, Kento Takenaka, Ami Kawamoto, Yusuke Matsuyama, Yumi Udagawa, Maiko Motobayashi, Hiromichi Shimizu, Toshimitsu Fujii, Eiko Saito, Masakazu Nagahori, Ryuichi Okamoto, Mamoru Watanabe
  • Journal Title: BMC Gastroenterol. Volume: 22 Issue: 1 Pages: 218-218
  • DOI: 10.1186/s12876-022-02300-2
  • Peer Reviewed / Open Access
• [Journal Article] Hemorrhagic gastric ulcer in a patient with Behcet's disease successfully treated with infliximab (2022)
  • Author(s): Shun Fujiwara, Ami Kawamoto, Maiko Motobayashi, Shuji Hibiya, Kento Takenaka, Hiromichi Shimizu, Eiko Saito, Toshimitsu Fujii, Masakazu Nagahori, Daisuke Kawata, Natsuka Umezawa, Tadashi Hosoya, Shinsuke Yasuda, Kazuo Ohtsuka, Ryuichi Okamoto
  • Journal Title: DEN Open. Volume: 3 Issue: 1
  • DOI: 10.1002/deo2.196
  • Peer Reviewed / Open Access
• [Journal Article] Serum Leucine-Rich α2 Glycoprotein: A Novel Biomarker for Transmural Inflammation in Crohn's Disease (2022)
  • Author(s): Kento Takenaka, Yoshio Kitazume, Ami Kawamoto, Toshimitsu Fujii, Yumi Udagawa, Ryosuke Wanatabe, Hiromichi Shimizu, Shuji Hibiya, Masakazu Nagahori, Kazuo Ohtsuka, Hiroyuki Sato, Akihiro Hirakawa, Mamoru Watanabe, Ryuichi Okamoto
  • Journal Title: Am J Gastroenterol. Volume: - Issue: 6 Pages: 1028-1035
  • DOI: 10.14309/ajg.0000000000002127
  • Peer Reviewed
• [Journal Article] Nickel particles are present in Crohn's disease tissue and exacerbate intestinal inflammation in IBD susceptible mice. (2022)
  • Author(s): Hiroki Matsuda, Yoichi Nibe-Shirakihara, Akiko Tamura, Emi Aonuma, Satoko Arakawa, Kana Otsubo, Yasuhiro Nemoto, Takashi Nagaishi, Kiichiro Tsuchiya, Shigeomi Shimizu, Averil Ma, Mamoru Watanabe, Motohiro Uo, Ryuichi Okamoto, Shigeru Oshima.
  • Journal Title: Biochemical and Biophysical Research Communications. Volume: 592 Pages: 74-80
  • DOI: 10.1016/j.bbrc.2021.12.111
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Activated mucosal-associated invariant T cells have a pathogenic role in a murine model of inflammatory bowel disease. (2022)
  • Author(s): usuke Yasutomi, Asako Chiba, Keiichi Haga, Goh Murayama, Ayako Makiyama, Taiga Kuga, Mamoru Watanabe, Ryuichi Okamoto, Akihito Nagahara, Takashi Nagaishi, Saichiko Miyake.
  • Journal Title: Cellular and Molecular Gastroenterology and Hepatology. Volume: 13 Issue: 1 Pages: 81-93
  • DOI: 10.1016/j.jcmgh.2021.08.018
  • Peer Reviewed / Open Access
• [Journal Article] 腸内細菌叢に対するIgAの重要性. (2022)
  • Author(s): 永石宇司.
  • Journal Title: 日本臨床腸内微生物学会誌. Volume: 24 Pages: 19-20
• [Journal Article] 外来クローン病患者における生体インピーダンス法を用いた体組成の評価 (2022)
  • Author(s): 斎藤 恵子, 太田 一樹, 長堀 正和, 藤井 俊光, 竹中 健人, 大塚和朗, 井津井 康浩, 篠原 夏美, 松下 由佳子, 岡本 隆一
  • Journal Title: 学会誌JASPEN Volume: 4 Pages: 35-43
  • Peer Reviewed
• [Journal Article] 特集 診断の決め手となった画像･所見Ⅱ-消化器 消化管-クローン病の診断 (2021)
  • Author(s): 北詰 良雄, 竹中 健人, 藤井 俊光, 長堀 正和, 大塚 和朗
  • Journal Title: 臨床放射線 Volume: 66 Issue: 12 Pages: 1491-1498
  • DOI: 10.18888/rp.0000001784
  • ISSN: 0009-9252
  • Year and Date: 2021-11-10
• [Journal Article] Immunoglobulin A-specific deficiency induces spontaneous inflammation specifically in the ileum (2021)
  • Author(s): Nagaishi Takashi、Watabe Taro、Kotake Kunihiko、Kumazawa Toshihiko、Aida Tomomi、et al.
  • Journal Title: Gut Volume: 71 Issue: 3 Pages: 487-496
  • DOI: 10.1136/gutjnl-2020-322873
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A potent endocytosis inhibitor Ikarugamycin up-regulates TNF production. (2021)
  • Author(s): Ai Minamidate, Michio Onizawa, Chikako Saito, Rie Hikichi, Tomoaki Mochimaru, Mai Murakami, Chiharu Sakuma, Takehito Asakawa, Yuichi Hiraoka, Shigeru Oshima, Takashi Nagaishi, Kiichiro Tsuchiya, Hiromasa Ohira, Ryuichi Okamoto, Mamoru Watanabe.
  • Journal Title: Biochemistry and Biophysics Reports. Volume: 27 Pages: 101065-101065
  • DOI: 10.1016/j.bbrep.2021.101065
  • Peer Reviewed / Open Access
• [Journal Article] Oral administration of D-serine prevents the onset and progression of colitis in mice. (2021)
  • Author(s): Takehito Asakawa, Michio Onizawa, Chikako Saito, Rie Hikichi, Daiki Yamada, Ai Minamidate, Tomoaki Mochimaru, Shun-ichiro Asahara, Yoshiaki Kido, Shigeru Oshima, Takashi Nagaishi, Kiichiro Tsuchiya, Hiromasa Ohira, Ryuichi Okamoto, Mamoru Watanabe.
  • Journal Title: Journal of Gastroenterolog. Volume: 56 Issue: 8 Pages: 732-745
  • DOI: 10.1007/s00535-021-01792-1
  • Peer Reviewed / Open Access
• [Journal Article] 免疫グロブリンAの欠損により回腸特異的な炎症が自然発症する. (2021)
  • Author(s): 安達貴弘，永石宇司.
  • Journal Title: 消化器学サイエンス. Volume: 5 Pages: 230-232
• [Journal Article] IBD診療現場のPros & Cons[No.3](その1) クローン病に対する生物学的製剤治療にチオプリン製剤を併用するか?併用するの立場から (2021)
  • Author(s): 長堀 正和
  • Journal Title: IBD Research Volume: 15 Pages: 177-180
• [Journal Article] 【最新の内視鏡を使いこなす】最新のスコープを使いこなす 小腸内視鏡 小腸内視鏡 オリンパス社内視鏡 (2021)
  • Author(s): 大塚 和朗, 竹中 健人, 日比谷 秀爾, 河本 亜美, 斎藤 詠子, 藤井 俊光, 長堀 正和, 清水 寛路, 岡本 隆一
  • Journal Title: 消化器内視鏡 Volume: 33 Pages: 1283-1287
• [Journal Article] 【エキスパートに学ぶ、安全で楽な外来内視鏡】外来内視鏡診療への展開 外来における小腸のバルーン内視鏡検査 (2021)
  • Author(s): 大塚 和朗, 竹中 健人, 日比谷 秀爾, 河本 亜美, 齊藤 詠子, 藤井 俊光, 長堀 正和, 岡本 隆一
  • Journal Title: 消化器内視鏡 Volume: 33 Pages: 1041-1046
• [Journal Article] 【IBDの栄養療法や栄養素を考える!】栄養指導の現在と未来 (2021)
  • Author(s): 長堀 正和
  • Journal Title: IBD Research Volume: 15 Pages: 72-76
• [Journal Article] Intravenous tacrolimus is a superior induction therapy for acute severe ulcerative colitis compared to oral tacrolimus (2021)
  • Author(s): Hiromichi Shimizu, Toshimitsu Fujii, Kenji Kinoshita, Ami Kawamoto, Shuji Hibiya, Kento Takenaka, Eiko Saito, Masakazu Nagahori, Kazuo Ohtsuka, Mamoru Watanabe, Ryuichi Okamoto
  • Journal Title: BMC Gastroenterol Volume: 21 Issue: 1 Pages: 494-494
  • DOI: 10.1186/s12876-021-02043-6
  • Peer Reviewed / Open Access
• [Journal Article] Higher concentrations of cytokine blockers are needed to obtain small bowel mucosal healing during maintenance therapy in Crohn's disease (2021)
  • Author(s): Kento Takenaka, Ami Kawamoto, Shuji Hibiya, Kohei Suzuki, Toshimitsu Fujii, Maiko Motobayashi, Hiromichi Shimizu, Masakazu Nagahori, Eiko Saito, Ryuichi Okamoto, Mamoru Watanabe, Kazuo Ohtsuka
  • Journal Title: Aliment Pharmacol Ther Volume: 54 Issue: 8 Pages: 1052-1060
  • DOI: 10.1111/apt.16551
  • Peer Reviewed
• [Journal Article] Substantial Epstein-Barr virus reactivation in a case of severe refractory ulcerative colitis: a possible role in exacerbation (2021)
  • Author(s): Shu Kato, Hiromichi Shimizu, Shohei Tomii, Hitoshi Uchida, Ami Kawamoto, Shuji Hibiya, Maiko Motobayashi, Kento Takenaka, Toshimitsu Fujii, Eiko Saito, Masakazu Nagahori, Kazuo Ohtsuka, Mariko Negi, Takumi Akashi, Takatoshi Matsuyama, Yusuke Kinugasa & Mamoru Watanabe
  • Journal Title: Clinical Journal of Gastroenterology Volume: 14 Issue: 2 Pages: 584-588
  • DOI: 10.1007/s12328-020-01319-w
  • Peer Reviewed
• [Journal Article] A nationwide survey concerning the mortality and risk of progressing severity due to arterial and venous thromboembolism in inflammatory boweldisease in Japan (2021)
  • Author(s): Katsuyoshi Ando,Kenji Watanabe, Sakiko Hiraoka, Taku Kobayashi,Masakazu Nagahori, Hiroki Ikeuchi, Shingo Kato, Motohiro Esaki, Makoto Naganuma, Satoshi Motoya,Masayuki Saruta, Hideo Suzuki, Hiroshi Nakase, Toshiaki Shimizu,Masahiro Iizuka, Mamoru Watanabe, YasuoSuzuki, and Tadakazu Hisamatsu
  • Journal Title: J Gastroenterol . Volume: 56 Issue: 12 Pages: 1062-1079
  • DOI: 10.1007/s00535-021-01829-5
  • Peer Reviewed
• [Journal Article] Intraepithelial Lymphocytes Suppress Intestinal Tumor Growth by Cell-to-Cell Contact via CD103/E-Cadherin Signal. (2021)
  • Author(s): Ryo Morikawa, Yasuhiro Nemoto, Yuki Yonemoto, Shohei Tanaka, Yuria Takei, Shigeru Oshima, Takashi Nagaishi, Kiichiro Tsuchiya, Kengo Nozaki , Tomohiro Mizutani, Tetsuya Nakamura, Mamoru Watanabe, Ryuichi Okamoto.
  • Journal Title: Cell Mol Gastroenterol Hepatol. Volume: 11 Issue: 5 Pages: 1483-1503
  • DOI: 10.1016/j.jcmgh.2021.01.014
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] 5-aminosalicylate-intolerant patients are at increased risk of colectomy for ulcerative colitis (2021)
  • Author(s): Shuji Hibiya, Yusuke Matsuyama, Toshimitsu Fujii, Chiaki Maeyashiki, Eiko Saito, Kimiko Ito, Hiromichi Shimizu, Ami Kawamoto, Maiko Motobayashi, Kento Takenaka, Masakazu Nagahori, Masayuki Kurosaki, Tsunehito Yauchi, Kazuo Ohtsuka, Takeo Fujiwara, Ryuichi Okamoto, Mamoru Watanabe
  • Journal Title: Aliment Pharmacol Ther Volume: 53 Issue: 1 Pages: 103-113
  • DOI: 10.1111/apt.16120
  • Peer Reviewed
• [Journal Article] Rapid prediction of 1-year efficacy of tofacitinib for treating refractory ulcerative colitis (2021)
  • Author(s): Hiromichi Shimizu, Toshimitsu Fujii, Shuji Hibiya, Maiko Motobayashi, Kohei Suzuki, Kento Takenaka, Eiko Saito, Masakazu Nagahori, Kazuo Ohtsuka, Mamoru Watanabe
  • Journal Title: Intest Res Volume: 19 Issue: 1 Pages: 115-118
  • DOI: 10.5217/ir.2020.00030
  • Peer Reviewed / Open Access
• [Journal Article] Week 2 Symptomatic Response with Vedolizumab as a Predictive Factor in Japanese Anti-TNFα-Naive Patients with Ulcerative Colitis: A post hoc Analysis of a Randomized, Placebo-Controlled Phase 3 Trial (2021)
  • Author(s): Masakazu Nagahori, Kenji Watanabe, Satoshi Motoya, Haruhiko Ogata, Takanori Kanai, Toshiyuki Matsui, Yasuo Suzuki, Philippe Pinton, Lyann Ursos, Shigeru Sakamoto, Mitsuhiro Shikamura, Tetsuharu Hori, Jovelle Fernandez, Toshifumi Hibi, Mamoru Watanabe
  • Journal Title: Digestion Volume: 15 Issue: 5 Pages: 1-11
  • DOI: 10.1159/000512235
  • Peer Reviewed / Open Access
• [Journal Article] Efficacy and safety of a new vedolizumab subcutaneous formulation in Japanese patients with moderately to severely active ulcerative colitis (2020)
  • Author(s): Taku Kobayashi, Hiroaki Ito, Toshifumi Ashida, Tadashi Yokoyama, Masakazu Nagahori, Tomoki Inaba, Mitsuhiro Shikamura, Takayoshi Yamaguchi, Tetsuharu Hori, Philippe Pinton, Mamoru Watanabe, Toshifumi Hibi
  • Journal Title: Intest Res Volume: 18 Issue: 4 Pages: 448-460
  • DOI: 10.5217/ir.2020.00026
  • Peer Reviewed / Open Access
• [Journal Article] Nickel ions attenuate autophagy flux and induce transglutaminase 2 (TG2) mediated post-translational modification of SQSTM1/p62. (2020)
  • Author(s): Emi Aonuma, Akiko Tamura, Hiroki Matsuda, Takehito Asakawa, Yuriko Sakamaki, Kana Otsubo, Yoichi Nibe, Michio Onizawa, Yasuhiro Nemoto, Takashi Nagaishi, Kiichiro Tsuchiya, Tetsuya Nakamura, Motohiro Uo, Mamoru Watanabe, Ryuichi Okamoto, Shigeru Oshima.
  • Journal Title: Biochem Biophys Res Commun. Volume: 542 Pages: 17-23
  • DOI: 10.1016/j.bbrc.2021.01.023
  • Peer Reviewed / Open Access
• [Journal Article] CEACAM1 specifically suppresses B cell receptor signaling-mediated activation.. (2020)
  • Author(s): Naoya Tsugawa, Daiki Yamada, Taro Watabe, Michio Onizawa, Shuang Wang, Yasuhiro Nemoto, Shigeru Oshima, Takeshi Tsubata, Takahiro Adachi, Yohei Kawano, Mamoru Watanabe, Richard S. Blumberg, Ryuichi Okamoto, Takashi Nagaishi.
  • Journal Title: Biochem Biophys Res Commun. Volume: 535 Pages: 99-105
  • DOI: 10.1016/j.bbrc.2020.11.126
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Receptor-Interacting Protein Kinase 3 (RIPK3) inhibits autophagic flux during necroptosis in intestinal epithelial cells. (2020)
  • Author(s): Otsubo K, Maeyashiki C, Nibe Y, Tamura A, Aonuma E, Matsuda H, Kobayashi M, Onizawa M, Nemoto Y, Nagaishi T, Okamoto R, Tsuchiya K, Nakamura T, Torii S, Itakura E, Watanabe M, Oshima S.
  • Journal Title: FEBS letters Volume: 594 Issue: 10 Pages: 1586-1595
  • DOI: 10.1002/1873-3468.13748
  • Peer Reviewed / Open Access
• [Journal Article] Pre-conception status, obstetric outcome and use of medications during pregnancy of systemic lupus erythematosus (SLE), rheumatoid arthritis (RA) and inflammatory bowel disease (IBD) in Japan: Multi-center retrospective descriptive study (2020)
  • Author(s): Sayaka Tsuda, Azusa Sameshima, Michikazu Sekine, Haruna Kawaguchi, Daisuke Fujita, Shintaro Makino, Akio Morinobu, Yohko Murakawa, Kiyoshi Matsui, Takao Sugiyama, Mamoru Watanabe, Yasuo Suzuki, Masakazu Nagahori, Atsuko Murashima, Tatsuya Atsumi, Kenji Oku, Nobuaki Mitsuda, Syuji Takei, Takako Miyamae, et al.
  • Journal Title: Mod Rheumatol Volume: 30 Issue: 5 Pages: 852-861
  • DOI: 10.1080/14397595.2019.1661592
  • Peer Reviewed
• [Presentation] Corticosteroid discontinuation and clinical outcomes in patients with moderately to severely active Crohn's disease treated with upadacitinib. (2023)
  • Author(s): M.C. Dubinsky, G. D’Haens, O. Dewit, P. Juillerat, R. Panaccione, T. Fujii, A.P. Lacerda, E. Dubcenco S. Anyanwu, C. Doshi, M. Mallick, A. Garrison, J. Liu, E.V. Loftus Jr.
  • Organizer: The 18th Annual congress of ECCO 2023
  • Int'l Joint Research
• [Presentation] Selective IgA deficiency induces spontaneous inflammation in the ileum. (2022)
  • Author(s): Nagaishi T, Yamada D, Inoue T, Blumberg RS, Okamoto R, Adachi T.
  • Organizer: The 51st Annual meeting of Japanese Society of Immunology.
  • Int'l Joint Research
• [Presentation] 選択的IgA欠損によって誘発される回腸特異的な免疫異常. (2022)
  • Author(s): 永石宇司, 山田大貴, 渡部太郎, 渡辺守, 岡本隆一, 安達貴弘.
  • Organizer: 第59回 日本消化器免疫学会
• [Presentation] Spontaneous inflammation specifically in the ileum is induced by selective IgA deficiency. (2022)
  • Author(s): Nagaishi T, Yamada D, Adachi T, Watanabe M, Okamoto R, Blumberg RS.
  • Organizer: Annual meeting of American Gastroenterology Association, Digestive Disease Week
  • Int'l Joint Research
• [Presentation] Patients with moderate to severe Crohn’s Disease with and without prior biologic failure demonstrate improved endoscopic outcomes with risankizumab: Results from phase 3 induction and maintenance trials. (2022)
  • Author(s): Ferrante, M.;Cao, Q.;Fujii, T.;Rausch, A.;Neimark, E.;Song, A.;Wallace, K.;Kligys, K.;Zhou, Q.;Kalabic, J.;Feagan, B.G.
  • Organizer: The 17th Annual congress of ECCO 2022
  • Int'l Joint Research
• [Presentation] IMPACT OF INFLAMMATORY BURDEN ON EFFICACY OF UPADACITINIB MAINTENANCE THERAPY IN ULCERATIVE COLITIS: RESULTS FROM THE PHASE 3 U-ACHIEVE STUDY. (2022)
  • Author(s): B. Feagan, J.-F. Colombel, J. Torres, T. Fujii, W. Zhou, X. Yao, Y. Sanchez Gonzalez, D. Ilo, X. Roblin.
  • Organizer: Annual meeting of UEGW 2022
  • Int'l Joint Research
• [Presentation] Clinical and Endoscopic Improvements with Risankizumab Induction and Maintenance Dosing Versus Placebo are Observed Irrespective of Number of Prior Failed Biologics. (2022)
  • Author(s): Marc Ferrante, Laurent Peyrin-Biroulet, Axel Dignass, David T. Rubin, Silvio Danese, Geert D'Haens, Kristina Kligys, Sofie Berg, Jasmina Kalabic, Javier Zambrano, Yafei Zhang, Toshimitsu Fujii, and Remo Panaccione.
  • Organizer: Annual scientific meeting of American College of Gastroenterology 2022
  • Int'l Joint Research
• [Presentation] The Lack of IgA spontaneously induces the inflammation only in the ileum. (2021)
  • Author(s): Daiki Yamada, Takahiro Adachi, Richard S. Blumberg, Ryuichi Okamoto, Takashi Nagaishi.
  • Organizer: The 50th Annual meeting of Japanese Society of Immunology
  • Int'l Joint Research
• [Presentation] A case of indolent T cell lymphoproliferative disorder of gastrointestinal tract with CCR4+ T cell infiltration. (2021)
  • Author(s): Daiki Yamada, Takashi Nagaishi, Eiko Saito, Masayoshi Fukuda, Ayako Arai, Ryuichi Okamoto.
  • Organizer: The 80th Annual meeting of Japanese Cancer Association
  • Int'l Joint Research
• [Presentation] BCR signaling-mediated activation in lymphoid tissues is regulated by the long isoform of CEACAM1. (2021)
  • Author(s): Takashi Nagaishi, Naoya Tsugawa, Daiki Yamada, Mamoru Watanabe, Richard S. Blumberg, Ryuichi Okamoto.
  • Organizer: Annual meeting of American Gastroenterology Association, Digestive Disease Week
  • Int'l Joint Research
• [Presentation] 腸内細菌叢に対するIgAの重要性. (2021)
  • Author(s): 永石宇司.
  • Organizer: 第24回日本臨床腸内微生物学会総会学術集会
  • Invited
• [Presentation] BCR-mediated activation in lymphoid tissues is regulated by Ceacam1. (2021)
  • Author(s): Takashi Nagaishi
  • Organizer: SMI Virtual Poster Hall
  • Int'l Joint Research / Invited
• [Presentation] 回腸に多発潰瘍を伴い診断に苦慮した腸管子宮内膜症の一例 (2021)
  • Author(s): 五月女 浩子, 河本 亜美, 小金井 一隆, 冨井 翔平, 竹中 健人, 日比谷 秀爾, 清水 寛路, 伊藤 剛, 水谷 知裕, 油井 史郎, 根本 泰宏, 藤井 俊光, 齊藤 詠子, 永石 宇司, 長堀 正和, 大塚 和朗, 岡本 隆一
  • Organizer: 第363回日本消化器病学会関東支部例会
• [Presentation] BCR signaling in lymphoid tissues regulated by the long isoform of Ceacam1. (2020)
  • Author(s): Takashi Nagaishi, Naoya Tsugawa, Daiki Yamada, Yudai Kojima, Michio Onizawa, Taro Watabe, Richard S. Blumberg, Mamoru Watanabe.
  • Organizer: FOCIS 2020
  • Int'l Joint Research
• [Presentation] 慢性大腸炎モデルにおけるAPLの発現解析 (2020)
  • Author(s): 山田大貴, 永石宇司, 津川直也, 小島裕大, 渡部太郎, 渡辺 守.
  • Organizer: 第48回日本臨床免疫学会総会
• [Presentation] A case of villous atrophy with CCR4+ T cell infiltration in the small intestine. (2020)
  • Author(s): Takashi Nagaishi, Daiki Yamada, Naoya Tsugawa, Taro Watabe, Eiko Saito, Masayoshi Fukuda, Ayako Arai, Kazuo Ohtsuka, Mamoru Watanabe.
  • Organizer: UEGW 2020
  • Int'l Joint Research
• [Presentation] BCR signaling in lymphoid tissues is regulated by the long isoform of Ceacam1. (2020)
  • Author(s): Takashi Nagaishi, Naoya Tsugawa, Daiki Yamada, Taro Watabe, Michio Onizawa, Yudai Kojima, Richard S. Blumberg, Mamoru Watanabe.
  • Organizer: MICS 2020
  • Int'l Joint Research
• [Presentation] 小腸難治性疾患の診断と治療の新知見 クローン病のバルーン内視鏡による小腸粘膜治癒評価 (2020)
  • Author(s): 竹中 健人, 大塚 和朗, 鈴木 康平, 日比谷 秀爾, 河本 亜美, 清水 寛路, 本林 麻衣子, 福田 将義, 藤井 俊光, 齊藤 詠子, 長堀 正和, 土屋 輝一郎, 渡辺 守, 岡本 隆一
  • Organizer: 第58回日本小腸学会学術集会
• [Presentation] 下部消化管内視鏡検査にてクローン病様所見を認めたスキルス胃癌の1例 (2020)
  • Author(s): 高橋 慶子, 竹中 健人, 三好 正人, 清水 寛路, 本林 麻衣子, 齊藤 詠子, 藤井 俊光, 長堀 正和, 大塚 和朗, 岡本 隆一
  • Organizer: 第663回日本内科学会関東地方会
• [Presentation] 5ASA不耐は潰瘍性大腸炎において予後不良である (2020)
  • Author(s): 藤井 俊光, 日比谷 秀爾, 前屋舗 千明, 齊藤 詠子, 竹中 健人, 清水 寛路, 長堀 正和, 大塚 和朗, 黒崎 雅之, 矢内 常人, 泉 並木, 渡辺 守
  • Organizer: 第106回日本消化器病学会
• [Presentation] 抗TNFα製剤治療が有効であった潰瘍性大腸炎術後に発症した壊疽性膿皮症の一例 (2020)
  • Author(s): 河崎 翔, 清水 寛路, 日比谷 秀爾, 本林 麻衣子, 竹中 健人, 油井 史郎, 根本 泰宏, 齊藤 詠子, 藤井 俊光, 岡田 英理子, 大島 茂, 岡本 隆一, 土屋 輝一郎, 永石 宇司, 長堀 正和, 大塚 和朗, 朝比奈 靖浩, 松山 貴俊, 加藤 恒平, 渡辺 守
  • Organizer: 第359回日本消化器病学会関東支部例会
• [Patent(Industrial Property Rights)] 炎症性腸疾患の治療方法およびそれに用いるための医薬組成物 (2020)
  • Inventor(s): 永石 宇司
  • Industrial Property Rights Holder: 永石 宇司
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2018-554239
  • Filing Date: 2020
  • Acquisition Date: 2020