Novel therapeutic strategy against colorectal cancer by intervening fluctuated differentiation status

• Project/Area Number: 20H03659
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Review Section: Basic Section 53010:Gastroenterology-related
• Research Institution: Kyoto University
• Principal Investigator: Seno Hiroshi 京都大学, 医学研究科, 教授 (90335266)
• Co-Investigator(Kenkyū-buntansha): 中西 祐貴 京都大学, 医学研究科, 特定助教 (40838679)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Project Status: Completed (Fiscal Year 2022)
• Budget Amount: ¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000); Fiscal Year 2022: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000); Fiscal Year 2021: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000); Fiscal Year 2020: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
• Keywords: 大腸がん

Outline of Research at the Start

がん組織の不均一性、可塑性をもたらす機序のひとつに、がん微小環境やがん細胞内で活性化するシグナルの変化によってがん細胞の分化がダイナミックに「揺らぐ」ことがあげられる。本研究では大腸がんを対象に、(1)分化の揺らぎを司る因子の包括的解析、(2)未分化性と分化フェノタイプを両立させるメカニズムの検討を行い、両者を統合して(3)分化の揺らぎを制御する多角的アプローチの検証を行う。それにより、大腸がんに分化の揺らぎをもたらすメカニズムに迫るとともに、分化の揺らぎを克服する新規大腸がん治療法の開発に結びつける。

Outline of Final Research Achievements

Cancer heterogeneity and plasticity are major causes of resistance against anti-cancer therapy. One of the reasons for those phenomena is fluctuation of cancer/cancer stem cell differentiation status. In this study, we performed comprehensive analyses for factors that affect fluctuation of differentiation status and stemness of colorectal cancer, and examined underlying mechanisms during those processes. We extracted a subtype of colorectal cancers that is associated cancer stemness phenotype, identified several factors that affect fluctuation of cancer differentiation status and cancer stemness, and showed potential effectiveness of intervening those newly identified factors.

Academic Significance and Societal Importance of the Research Achievements

本研究では大腸を舞台に、がん細胞に分化の揺らぎと幹細胞性をもたらすメカニズムの解析、分化の揺らぎとがん幹細胞を標的とするがん治療法開発へ向けた基盤的データ獲得を目的とした。マテリアルとなった種々の遺伝子改変マウス、マウスおよびヒト由来オルガノイド、腫瘍/がん幹細胞マーカー、経時的観察を可能にするライブ・イメージング系、および腫瘍/がん幹細胞の選択的排除システムは、研究代表者らが独自に検証、樹立してきたもので、本研究のオリジナリティは高い。がん幹細胞とその揺らぎは、大腸がんのほか、膵臓がん、胃がん、胆道がん等にも存在し、将来的に臓器横断的な消化器がんの治療法開発につながる可能性も考えられる。

Research Products

• [Int'l Joint Research] (DKFZ and DKTK(ドイツ)
• [Journal Article] Optimization of the proliferation and persistency of CAR T cells derived from human induced pluripotent stem cells. (2023)
  • Author(s): Ueda T, Shiina S, Iriguchi S, Terakura S, Kawai Y, Kabai R, Sakamoto S, Watanabe A, Ohara K, Wang B, Xu H, Minagawa A, Hotta A, Woltjen K, Uemura Y, Kodama Y, Seno H, Nakatsura T, Tamada K, Kaneko S.
  • Journal Title: Nat Biomed Eng. Volume: 7(1) Pages: 24-37
  • DOI: 10.1038/s41551-022-00969-0
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Context-Dependent Roles of Hes1 in the Adult Pancreas and Pancreatic Tumor Formation. (2022)
  • Author(s): Marui S, Nishikawa Y, Shiokawa M, Yokode M, Matsumoto S, Muramoto Y, Ota S, Nakamura T, Yoshida H, Okada H, Kuwada T, Matsumori T, Kuriyama K, Fukuda A, Saur D, Aoi T, Uza N, Kodama Y, Chiba T, Seno H.
  • Journal Title: Gastroenterology. Volume: 163 Issue: 6 Pages: 1613-1629
  • DOI: 10.1053/j.gastro.2022.08.048
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Loss of Arid1a and Pten in Pancreatic Ductal Cells Induces Intraductal Tubulopapillary Neoplasm via the YAP/TAZ Pathway. (2022)
  • Author(s): Fukunaga Y, Fukuda A, Omatsu M, Namikawa M, Sono M, Masuda T, Araki O, Nagao M, Yoshikawa T, Ogawa S, Hiramatsu Y, Muta Y, Tsuda M, Maruno T, Nakanishi Y, Ferrer J, Tsuruyama T, Masui T, Hatano E, Seno H.
  • Journal Title: Gastroenterology. Volume: 163 Issue: 2 Pages: 466-480
  • DOI: 10.1053/j.gastro.2022.04.020
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Expansion of gastric intestinal metaplasia with copy number aberrations contributes to field cancerization (2022)
  • Author(s): Kumagai Ken、Shimizu Takahiro、Takai Atsushi、Kakiuchi Nobuyuki、Takeuchi Yasuhide、Hirano Tomonori、Takeda Haruhiko、Mizuguchi Aya、Teramura Mari、Ito Takahiko、Iguchi Eriko、Nikaido Mitsuhiro、Eso Yuji、Takahashi Ken、Ueda Yoshihide、Miyamoto Shin-ichi、Obama Kazutaka、Ogawa Seishi、Marusawa Hiroyuki、Seno Hiroshi
  • Journal Title: Cancer Research Volume: - Issue: 9 Pages: 1712-1723
  • DOI: 10.1158/0008-5472.can-21-1523
  • Peer Reviewed
• [Journal Article] Concurrent activation of Kras and canonical Wnt signaling induces premalignant lesions that progress to extrahepatic biliary cancer in mice (2022)
  • Author(s): Nagao M, Fukuda A, Omatsu M, Namikawa M, Sono M, Fukunaga Y, Masuda T, Araki O, Yoshikawa T, Ogawa S, Masuo K, Goto N, Hiramatsu Y, Muta Y, Tsuda M, Maruno T, Nakanishi Y, Taketo MM, Ferrer J, Tsuruyama T, Nakanuma Y, Taura K, Uemoto S, Seno H.
  • Journal Title: Cancer Res. Volume: - Issue: 9 Pages: 1803-1817
  • DOI: 10.1158/0008-5472.can-21-2176
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Genetic Landscape of Multistep Hepatocarcinogenesis (2022)
  • Author(s): Takeda Haruhiko、Takai Atsushi、Eso Yuji、Takahashi Ken、Marusawa Hiroyuki、Seno Hiroshi
  • Journal Title: Cancers Volume: 14 Issue: 3 Pages: 568-568
  • DOI: 10.3390/cancers14030568
  • Peer Reviewed / Open Access
• [Journal Article] In situ vaccination using unique TLR9 ligand K3-SPG induces long-lasting systemic immune response and synergizes with systemic and local immunotherapy (2022)
  • Author(s): Okada H, Takahashi K, Yaku H, Kobiyama K, Iwaisako K, Zhao X, Shiokawa M, Uza N, Kodama Y, Ishii KJ, Seno H.
  • Journal Title: Sci Rep. Volume: 12 Issue: 1 Pages: 2132-2132
  • DOI: 10.1038/s41598-022-05702-0
  • Peer Reviewed / Open Access
• [Journal Article] Gastric Hyperplastic Polyps Can Shrink After Discontinuation of Proton Pump Inhibitors: A Case Series Compared With Continuation of Proton Pump Inhibitors (2022)
  • Author(s): Nikaido M, Miyamoto S, Utsumi T, Shimizu T, Nakanishi Y, Kumagai K, Teramura M, Setoyama T, Seno H.
  • Journal Title: J Clin Gastroenterol. Volume: 56 Issue: 3 Pages: e216-e221
  • DOI: 10.1097/mcg.0000000000001577
  • Peer Reviewed
• [Journal Article] Identification of an Anti?Integrin αvβ6 Autoantibody in Patients With Ulcerative Colitis (2021)
  • Author(s): Kuwada T, Shiokawa M, Kodama Y, Ota S, Kakiuchi N, Nannya Y, Yamazaki H, Yoshida H, Nakamura T, Matsumoto S, Muramoto Y, Yamamoto S, Honzawa Y, Kuriyama K, Okamoto K, Hirano T, Okada H, Marui S, Sogabe Y, Morita T, Matsumori T, Mima A, Nishikawa Y, Ueda T, Matsumura K, Uza N, Chiba T, Seno H
  • Journal Title: Gastroenterology Volume: - Issue: 7 Pages: 2383-2394
  • DOI: 10.1053/j.gastro.2021.02.019
  • NAID: 120006976020
  • Peer Reviewed / Open Access
• [Journal Article] Essential role of Notch/Hes1 signaling in postnatal pancreatic exocrine development (2021)
  • Author(s): Kuriyama K, Kodama Y, Shiokawa M, Nishikawa Y, Marui S, Kuwada T, Sogabe Y, Kakiuchi N, Tomono T, Matsumori T, Mima A, Morita T, Ueda T, Tsuda M, Yamauchi Y, Sakuma Y, Ota Y, Maruno T, Uza N, Kageyama R, Chiba T, Seno H.
  • Journal Title: J Gastroenterol. Volume: 56 Pages: 673-687
  • Peer Reviewed
• [Journal Article] Factors associated with inaccurate size estimation of colorectal polyps: A multicenter cross-sectional study (2021)
  • Author(s): Utsumi T, Horimatsu T, Nishikawa Y, Teramoto A, Hirata D, Iwatate M, Tanaka S, Ikezawa N, Esaki M, Osera S, Ebisutani C, Agatsuma N, Saito H, Sano Y, Seno H.
  • Journal Title: J Gastroenterol Hepatol. Volume: 36 Issue: 8 Pages: 2224-2229
  • DOI: 10.1111/jgh.15464
  • Peer Reviewed
• [Journal Article] Medical costs according to the stages of colorectal cancer: an analysis of health insurance claims in Hachioji, Japan (2021)
  • Author(s): Utsumi T, Horimatsu T, Nishikawa Y, Hoshino N, Takahashi Y, Goto R, Kashihara S, Fukuyoshi J, Nakayama T, Seno H.
  • Journal Title: J Gastroenterol. Volume: 56 Issue: 10 Pages: 903-913
  • DOI: 10.1007/s00535-021-01798-9
  • Peer Reviewed / Open Access
• [Journal Article] Brg1 is required to maintain colorectal cancer stem cells (2021)
  • Author(s): Yoshikawa Takaaki、Fukuda Akihisa、Omatsu Mayuki、Namikawa Mio、Sono Makoto、Fukunaga Yuichi、Masuda Tomonori、Araki Osamu、Nagao Munemasa、Ogawa Satoshi、Masuo Kenji、Goto Norihiro、Hiramatsu Yukiko、Muta Yu、Tsuda Motoyuki、Maruno Takahisa、Nakanishi Yuki、Kawada Kenji、Takaishi Shigeo、Seno Hiroshi
  • Journal Title: The Journal of Pathology Volume: 255 Issue: 3 Pages: 257-269
  • DOI: 10.1002/path.5759
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Indolent feature of Helicobacter pylori-uninfected intramucosal signet ring cell carcinomas with CDH1 mutations (2021)
  • Author(s): Nikaido Mitsuhiro、Ogawa Seishi, et al.
  • Journal Title: Gastric Cancer Volume: 24 Issue: 5 Pages: 1102-1114
  • DOI: 10.1007/s10120-021-01191-8
  • NAID: 40022653243
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Visceral fat obesity is the key risk factor for the development of reflux erosive esophagitis in 40-69-years subjects (2021)
  • Author(s): Shinya Ohashi, Takahisa Maruno, Keita Fukuyama, Osamu Kikuchi, Tomohiko Sunami, Ｙuki Ｋondo, Ｓeiichiro Ｉmai, Ｍatsushima Ａki, Ｋimiyo Ｓuzuki, Ｆumika Ｕsui, Ｍasahiro Ｙakami, Ａtsushi Yamada, Hiroyoshi Isoda, Shigemi Matsumoto, Hiroshi Seno, Manabu Muto, Mayumi Inoue
  • Journal Title: Esophagus Volume: 18 Issue: 4 Pages: 889-899
  • DOI: 10.1007/s10388-021-00859-5
  • Peer Reviewed / Open Access
• [Journal Article] Interinstitutional differences in diagnosis of the morphology of colorectal polyps in Japan: a nationwide database analysis (2021)
  • Author(s): Utsumi T, Horimatsu T, Nishikawa Y, Seno H.
  • Journal Title: Eur J Gastroenterol Hepatol. Volume: 33 Issue: 1S Pages: e1072-e1073
  • DOI: 10.1097/meg.0000000000002022
  • Peer Reviewed
• [Journal Article] SNAIL2 contributes to tumorigenicity and chemotherapy resistance in pancreatic cancer by regulating IGFBP2 (2021)
  • Author(s): Masuo K, Chen R, Yogo A, Sugiyama A, Fukuda A, Masui T, Uemoto S, Seno H, Takaishi S.
  • Journal Title: Cancer Sci. Volume: 112 Issue: 12 Pages: 4987-4999
  • DOI: 10.1111/cas.15162
  • Peer Reviewed / Open Access
• [Journal Article] Visualization of stem cell activity in pancreatic cancer expansion by direct lineage tracing with live imaging (2021)
  • Author(s): Maruno Takahisa、Fukuda Akihisa、Goto Norihiro、Tsuda Motoyuki、Ikuta Kozo、Hiramatsu Yukiko、Ogawa Satoshi、Nakanishi Yuki、Yamaga Yuichi、Yoshioka Takuto、Takaori Kyoichi、Uemoto Shinji、Saur Dieter、Chiba Tsutomu、Seno Hiroshi
  • Journal Title: eLife Volume: 10 Pages: 1-24
  • DOI: 10.7554/elife.55117
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The role of SWI/SNF chromatin remodeling complex in pancreatic cancer. *corresponding author (2021)
  • Author(s): 2.Motoyuki Tsuda, Akihisa Fukuda, Munenori Kawai, Osamu Araki, Hiroshi Seno.
  • Journal Title: Cancer Science Volume: 112 Issue: 2 Pages: 490-497
  • DOI: 10.1111/cas.14768
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Setdb1 inhibits p53-mediated apoptosis and is required for formation of pancreatic ductal adenocarcinomas in mice. (2020)
  • Author(s): 6.Ogawa S, Fukuda A, Matsumoto Y, Hanyu Yu, Sono M, Fukunaga Y, Masuda T, Araki O, Nagao M, Yoshikawa T, Goto N, Hiramatsu Y, Tsuda M, Maruno T, Nakanishii Y, Hussein S.M, Tsuruyama T, Takaori K, Uemotoio S, Seno H.
  • Journal Title: Gastroenterology Volume: 159 Issue: 2 Pages: 682-696
  • DOI: 10.1053/j.gastro.2020.04.047
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Rb and p53 Execute Distinct Roles in the Development of Pancreatic Neuroendocrine Tumors (2020)
  • Author(s): Yamauchi Yuki、Kodama Yuzo、Uza Norimitsu、Masuda Atsuhiro、Tatsuoka Hisato、Masui Toshihiko、Inagaki Nobuya、Uemoto Shinji、Chiba Tsutomu、Seno Hiroshi
  • Journal Title: Cancer Research Volume: 80 Issue: 17 Pages: 3620-3630
  • DOI: 10.1158/0008-5472.can-19-2232
  • Peer Reviewed / Open Access
• [Journal Article] CXCR4 in tumor epithelial cells mediates desmoplastic reaction in pancreatic ductal adenocarcinoma. (2020)
  • Author(s): Morita, T., Kodama, Y., Shiokawa, M., Kuriyama, K., Marui, S., Kuwada, T., Sogabe, Y., Matsumori, T., Kakiuchi, N., Tomono, T., Mima, A., Ueda, T., Tsuda, M., Yamauchi, Y., Nishikawa, Y., Sakuma, Y., Ota, Y., Maruno, T., Uza, N., Nagasawa, T., Chiba, T., and Seno, H.
  • Journal Title: Cancer Res. Volume: 80 Issue: 19 Pages: 4058-4070
  • DOI: 10.1158/0008-5472.can-19-2745
  • Peer Reviewed
• [Journal Article] Short educational video to improve the accuracy of colorectal polyp size estimation: Multicenter prospective study. (2020)
  • Author(s): Utsumi T, Horimatsu T, Nishikawa Y, Teramoto A, Hirata D, Iwatate M, Sano Y, Seno H.
  • Journal Title: Dig Endosc Volume: 32 Issue: 7 Pages: 1074-1081
  • DOI: 10.1111/den.13638
  • Peer Reviewed
• [Journal Article] Hes1 Is Essential in Proliferating Ductal Cell-Mediated Development of Intrahepatic Cholangiocarcinoma (2020)
  • Author(s): Matsumori T, Kodama Y, Takai A, Shiokawa M, Nishikawa Y, Matsumoto T, Takeda H, Marui S, Okada H, Hirano T, Kuwada T, Sogabe Y, Kakiuchi N, Tomono T, Mima A, Morita T, Ueda T, Tsuda M, Yamauchi Y, Kuriyama K, Sakuma Y, Ota Y, Maruno T, Uza N, Marusawa H, Kageyama R, Chiba T, Seno H.
  • Journal Title: Cancer Research Volume: 80 Issue: 23 Pages: 5305-5316
  • DOI: 10.1158/0008-5472.can-20-1161
  • Peer Reviewed
• [Presentation] クロマチンリモデリング因子Brg1はマウス腸腫瘍およびヒト大腸癌の幹細胞性に重要な役割を果たす (2022)
  • Author(s): 吉川貴章、福田晃久、妹尾浩
  • Organizer: 第108回日本消化器病学会総会
• [Presentation] Simultaneous activation of Notch and Kras pathways leads to biliary cancer via premalignant lesions through mTOR pathway (2022)
  • Author(s): 並川実桜、福田晃久、薗誠、益田朋典、長尾宗政、平松由紀子、丸野貴久、中西祐貴、妹尾浩
  • Organizer: 第81回 日本癌学会学術総会
• [Presentation] Kras および WNT signaling の活性化により肝外胆管・胆嚢に前癌 病変が形成され、胆道癌に進展する (2022)
  • Author(s): 長尾 宗政、福田 晃久、水越 健太、岩根 康祐、河相 宗矩、山川 剛、尾松 万悠紀、並川 実桜、薗 誠、益田 朋典、平松 由紀子、 丸野 貴久、中西 祐貴、妹尾 浩
  • Organizer: 第81回 日本癌学会学術総会
• [Presentation] Reck suppresses pancreatic cancer formation, epithelial-mesenchymal transition and metastasis. (2022)
  • Author(s): Tomonori Masuda, Fukuda Akihisa, Sono Makoto, Fukunaga Yuichi, Yoshikawa Takaaki, Araki Osamu, Munemasa Nagao, Hiramatsu Yukiko, Ogawa Satoshi,Tsuda Motoyuki, Maruno Takahisa, Nakanishi Yuki, Matsuzaki Tomoko, Noda Makoto, Seno Hiroshi.
  • Organizer: 第81回 日本癌学会学術総会
• [Presentation] Insights into initiation and progression of PDAC. (2022)
  • Author(s): Akihisa Fukuda, Takahisa Maruno, Kyoichi Takaori, Hiroshi Seno
  • Organizer: American Pancreatic Association Annual meeting 2022
  • Int'l Joint Research
• [Presentation] 大腸の恒常性維持における EP4の役割と再生医療への応用について (2021)
  • Author(s): 松本善秀、 中西祐貴、 福田晃久
  • Organizer: 第107回日本消化器病学会総会
• [Presentation] 慢性萎縮性胃炎粘膜を構成する腸上皮化生腺管のゲノム異常の網羅的解析 (2021)
  • Author(s): 熊谷健、清水孝洋、高井淳
  • Organizer: 第80回日本癌学会学術総会
• [Presentation] SETDB1 IS REQUIRED FOR FORMATION OF PANCREATIC DUCTAL ADENOCARCINOMA BY INHIBITING APOPTOSIS THROUGH REGULATION OF P53 EXPRESSION (2021)
  • Author(s): 小川智、福田晃久、妹尾浩
  • Organizer: 第80回日本癌学会学術総会
• [Presentation] Bmi1 is required for pancreatic ductal adenocarcinoma formation through regulating PI3K/AKT pathway and acinar genes (2021)
  • Author(s): Makoto Sono, Akihisa Fukuda, Tomonori Masuda, Yuichi Fukunaga, Takaaki Yoshikawa, Osamu Araki, Munemasa Nagao, Satoshi Ogawa, Yukiko Hiramatsu, Takahisa Maruno, Yuki Nakanishi, Hiroshi Seno
  • Organizer: 第80回日本癌学会学術総会
• [Presentation] Simultaneous loss of Arid1a and Pten in pancreatic ductal cells induces ITPN and PDAC through activation of YAP/TAZ (2021)
  • Author(s): 福永裕一、福田晃久、薗誠、益田朋典、吉川貴章、荒木理、長尾宗政、平松由紀子、小川智、丸野貴久、中西佑貴、鶴山竜昭、妹尾浩
  • Organizer: 第80回日本癌学会学術総会
• [Presentation] Reck suppresses pancreatic cancer formation, epithelial-mesenchymal transition and metastasis in mice. (2021)
  • Author(s): Tomonori Masuda, Fukuda Akihisa, Sono Makoto, Fukunaga Yuichi, Yoshikawa Takaaki, Araki Osamu, Munemasa Nagao, Hiramatsu Yukiko, Ogawa Satoshi,Tsuda Motoyuki, Maruno Takahisa, Nakanishi Yuki, Matsuzaki Tomoko, Noda Makoto, Seno Hiroshi.
  • Organizer: 第80回日本癌学会学術総会
• [Presentation] Analysis of pancreato-biliary cancer development using mice and organoids (2021)
  • Author(s): Hiroshi Seno, Munemasa Nagao, Yuichi Fukunaga, Satoshi Ogawa, Takahisa Maruno, Akihisa Fukuda
  • Organizer: 第80回日本癌学会学術総会
• [Presentation] Bmi1 is required for pancreatic cancer formation through regulating PI3K/AKT pathway in mice. (2020)
  • Author(s): Sono Makoto, Fukuda Akihisa, Tsuda Motoyuki, Seno Hiroshi
  • Organizer: 第79回日本癌学会学術総会
• [Presentation] KrasおよびWntシグナルは幽門腺型胆嚢腺腫BilINの形成に重要である (2020)
  • Author(s): 長尾宗政、福田晃久、尾松万悠紀、並川実桜、薗誠、福永裕一、益田朋典、荒木理、吉川貴章、小川智、平松由紀子、津田喬之、丸野貴久、中西祐貴、妹尾浩
  • Organizer: 第79回日本癌学会学術総会
• [Presentation] Brg1, a subunit of the SWI/SNF complex, is critical for growth and metastasis of pancreatic cancer cells in mice. (2020)
  • Author(s): Osamu Araki, Akihisa Fukuda, Motoyuki Tsuda, Hiroshi Seno
  • Organizer: 第79回日本癌学会学術総会
• [Presentation] Setdb1 deletion protects against formation of pancreatic ductal adenocarcinoma by inducing p53-mediated apoptosis. (2020)
  • Author(s): Satoshi Ogawa, Akihisa Fukuda, Araki Osamu, Munemasa Nagao, Takaaki Yoshikawa, Yukiko Hiramatsu, Motoyuki Tsuda, Takahisa Maruno, Yuki Nakanishi, Hiroshi Seno
  • Organizer: 第79回日本癌学会学術総会
• [Presentation] Intestinal tumor stem cell specific ablation of Brg1 resulted in reduction of intestinal tumors with increased apoptosis. (2020)
  • Author(s): Takaaki Yoshikawa, Akihisa Fukuda, Hiroshi Seno.
  • Organizer: 第79回日本癌学会学術総会
• [Presentation] KrasおよびWntシグナルは幽門腺型胆嚢腺腫，幽門腺形質をもつBilINの形成に重要である (2020)
  • Author(s): 長尾宗政、福田晃久、妹尾浩
  • Organizer: 第28回日本消化器関連学会週間
• [Presentation] SETDB1 IS REQUIRED FOR FORMATION OF PANCREATIC DUCTAL ADENOCARCINOMA BY INHIBITING APOPTOSIS THROUGH REGULATION OF P53 EXPRESSION. (2020)
  • Author(s): Satoshi Ogawa, Akihisa Fukuda, Araki Osamu, Munemasa Nagao, Takaaki Yoshikawa, Yukiko Hiramatsu, Motoyuki Tsuda, Takahisa Maruno, Yuki Nakanishi, Hiroshi Seno
  • Organizer: 51st Annual Meeting of the American Pancreatic Association
  • Int'l Joint Research
• [Remarks] 京都大学消化器内科ウェブサイト
  • URL: https://gastro.kuhp.kyoto-u.ac.jp/
• [Remarks] 京都大学消化器内科ホームページ
  • URL: https://www.kuhp.kyoto-u.ac.jp/~gastro/