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Discovery of cancer genes driving NASH-HCC for personalized therapy

Research Project

Project/Area Number 20H03661
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 53010:Gastroenterology-related
Research InstitutionOsaka University

Principal Investigator

Kodama Takahiro  大阪大学, 大学院医学系研究科, 助教 (10623275)

Project Period (FY) 2020-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2022: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2021: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2020: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
Keywords肝癌 / 肝細胞癌 / NASH / がん抑制遺伝子 / CRISPR / トランスポゾン / 遺伝子スクリーニング / 肝内胆管癌 / Traf3 / HCC / スクリーニング / ドライバー遺伝子 / プール型ライブラリー
Outline of Research at the Start

本研究は、非アルコール性脂肪肝炎(NASH)からの肝癌発症・進展の分子メカニズムの解明を目指して、ドライバー遺伝子のカタログを作成することを目的とする。申請者はマウス生体内での癌遺伝子探索技術を用いて、これまでにNASH由来肝癌ドライバー遺伝子候補を多数同定した。本研究ではNASH由来肝癌臨床試料のデータ解析と動物モデルで得られた結果を統合し、独自に開発した新規技術を用いて、ハイスループットな癌ドライバー遺伝子候補の検証並びに機能解析を行う。最終的にはカタログ化されたドライバー遺伝子群を対象としたNASH由来肝癌診断パネルを作成し、個別化医療の実現を目指す。

Outline of Final Research Achievements

We have established a new screening system that can identify hepatocellular carcinoma (HCC) cancer genes in a high-throughput manner by introducing CRISPR/Cas libraries into mouse liver. We aimed to validate a large number of candidate HCC cancer genes obtained from previously-performed transposon insertional mutation screens and found that Sav1, Gsk3b, Setd2, and Lonp2 function as new tumor suppressor genes for NASH-based HCC. In addition, we found that the Traf3 gene regulates the trans-differentiation from hepatocytes to cholangiocytes, and the dysregulation of the Traf3/NIK pathway
promotes intrahepatic cholangiocarcinoma development from hepatocytes via trans-differentiation.

Academic Significance and Societal Importance of the Research Achievements

樹立した新たなマウスシステムは、生体内において肝癌の発症に寄与する分子を効率よく同定できる新しい技術であり、今後肝癌における発症メカニズムの解明や新たな治療標的の同定に応用できる研究成果である。また、本研究で同定された新たな肝癌のがん抑制遺伝子やその下流経路を標的とした肝癌治療薬や予防法開発に繋がる成果と考えられる。肝癌は全世界での死亡者数4位(約78万人)の難治性がんであり、日本国内に3万5千人の患者が存在し、年間死亡者数は2万9千人に上る非常に予後不良な癌である。本研究は治療法開発などを通じた肝癌の予後改善に繋げるための、基礎的に重要な成果であり、社会的意義は大きい。

Report

(4 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Annual Research Report
  • 2020 Annual Research Report
  • Research Products

    (49 results)

All 2023 2022 2021 2020 Other

All Int'l Joint Research (2 results) Journal Article (17 results) (of which Int'l Joint Research: 8 results,  Peer Reviewed: 17 results,  Open Access: 8 results) Presentation (26 results) (of which Int'l Joint Research: 7 results,  Invited: 5 results) Book (1 results) Patent(Industrial Property Rights) (3 results)

  • [Int'l Joint Research] Icahn School of Medicine at Mount Sinai(米国)

    • Related Report
      2022 Annual Research Report
  • [Int'l Joint Research] Newcastle University(英国)

    • Related Report
      2021 Annual Research Report
  • [Journal Article] STAT3 is Activated by CTGF-mediated Tumor-stroma Cross Talk to Promote HCC Progression2023

    • Author(s)
      Makino Yuki、Hikita Hayato、Kato Seiya、Sugiyama Masaya、Shigekawa Minoru、Sakamoto Tatsuya、Sasaki Yoichi、Murai Kazuhiro、Sakane Sadatsugu、Kodama Takahiro、Sakamori Ryotaro、Kobayashi Shogo、Eguchi Hidetoshi、Takemura Nobuyuki、Kokudo Norihiro、Yokoi Hideki、Mukoyama Masashi、Tatsumi Tomohide、Takehara Tetsuo
    • Journal Title

      Cellular and Molecular Gastroenterology and Hepatology

      Volume: 15 Issue: 1 Pages: 99-119

    • DOI

      10.1016/j.jcmgh.2022.09.006

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Thrombospondin-2 as a Predictive Biomarker for Hepatocellular Carcinoma after Hepatitis C Virus Elimination by Direct-Acting Antiviral2023

    • Author(s)
      Matsumae Takayuki、Kodama Takahiro、Tahata Yuki、Oshita Masahide、Hiramatsu Naoki、Morishita Naoki、Ohkawa Kazuyoshi、Hijioka Taizo、Sakakibara Mitsuru、Doi Yoshinori、Kakita Naruyasu、Yakushijin Takayuki、Sakamori Ryotaro、Hikita Hayato、Tatsumi Tomohide、Takehara Tetsuo
    • Journal Title

      Cancers

      Volume: 15 Issue: 2 Pages: 463-463

    • DOI

      10.3390/cancers15020463

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Multiomics identifies the link between intratumor steatosis and the exhausted tumor immune microenvironment in hepatocellular carcinoma2022

    • Author(s)
      Murai Hiroki、Kodama Takahiro、Maesaka Kazuki、Tanaka Satoshi、Mita Eiji、Ohkawa Kazuyoshi、Hikita Hayato、Sakamori Ryotaro、Tatsumi Tomohide、Eguchi Hidetoshi、Morii Eiichi、Takehara Tetsuo
    • Journal Title

      Hepatology

      Volume: 77 Issue: 1 Pages: 77-91

    • DOI

      10.1002/hep.32573

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Constitutive Activation of the Tumor Suppressor p53 in Hepatocytes Paradoxically Promotes Non-Cell Autonomous Liver Carcinogenesis2022

    • Author(s)
      Makino Yuki、Hikita Hayato、Fukumoto Kenji、Sung Ji Hyun、Sakano Yoshihiro、Murai Kazuhiro、Sakane Sadatsugu、Kodama Takahiro、Sakamori Ryotaro、Kondo Jumpei、Kobayashi Shogo、Tatsumi Tomohide、Takehara Tetsuo
    • Journal Title

      Cancer Research

      Volume: 82 Issue: 16 Pages: 2860-2873

    • DOI

      10.1158/0008-5472.can-21-4390

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Circulating Cell-Free DNA Profiling Predicts the Therapeutic Outcome in Advanced Hepatocellular Carcinoma Patients Treated with Combination Immunotherapy2022

    • Author(s)
      Matsumae Takayuki、Kodama Takahiro、Myojin Yuta、Maesaka Kazuki、Nakabori Tasuku、Ohkawa Kazuyoshi、Miyazaki Masanori、Tanaka Satoshi、Mita Eiji、Tawara Seiichi、Yakushijin Takayuki、Nozaki Yasutoshi、Hagiwara Hideki、Tahata Yuki、Yamada Ryoko、Hikita Hayato、Tatsumi Tomohide、Takehara Tetsuo
    • Journal Title

      Cancers

      Volume: 14 Issue: 14 Pages: 3367-3367

    • DOI

      10.3390/cancers14143367

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] TNF receptor-related factor 3 inactivation promotes the development of intrahepatic cholangiocarcinoma through NF‐κB‐inducing kinase-mediated hepatocyte transdifferentiation2022

    • Author(s)
      Shiode Yuto、Kodama Takahiro、Shigeno Satoshi、Murai Kazuhiro、Tanaka Satoshi、Newberg Justin Y.、Kondo Jumpei、Kobayashi Shogo、Yamada Ryoko、Hikita Hayato、Sakamori Ryotaro、Suemizu Hiroshi、Tatsumi Tomohide、Eguchi Hidetoshi、Jenkins Nancy A.、Copeland Neal G.、Takehara Tetsuo
    • Journal Title

      Hepatology

      Volume: - Issue: 2 Pages: 395-410

    • DOI

      10.1002/hep.32317

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Interleukin-6 Is a Circulating Prognostic Biomarker for Hepatocellular Carcinoma Patients Treated with Combined Immunotherapy2022

    • Author(s)
      Myojin Yuta、Kodama Takahiro、Sakamori Ryotaro、Maesaka Kazuki、Matsumae Takayuki、Tahata Yuki、Yamada Ryoko、Hikita Hayato、Tatsumi Tomohide、Takehara Tetsuo
    • Journal Title

      Cancers

      Volume: 14 Issue: 4 Pages: 883-883

    • DOI

      10.3390/cancers14040883

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dysregulation of PI3K and Hippo signaling pathways synergistically induces chronic pancreatitis via CTGF upregulation2021

    • Author(s)
      Tamura Takeshi、Kodama Takahiro、Sato Katsuhiko、Murai Kazuhiro、Yoshioka Teppei、Shigekawa Minoru、Yamada Ryoko、Hikita Hayato、Sakamori Ryotaro、Akita Hirofumi、Eguchi Hidetoshi、Johnson Randy L.、Yokoi Hideki、Mukoyama Masashi、Tatsumi Tomohide、Takehara Tetsuo
    • Journal Title

      Journal of Clinical Investigation

      Volume: 131 Issue: 13

    • DOI

      10.1172/jci143414

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Hepatitis C virus modulates signal peptide peptidase to alter host protein processing.2021

    • Author(s)
      11.Hirano J, Yoshio S, Sakai Y, Songling L, Suzuki T, Itoh Y, Zhang H, Chen DV, Haga S, Oomori H, Kodama T, Maeda Y, Ono Y, Takahashi Y, Standley DM, Yamamoto M, Moriishi K, Moriya K, Kanto T, Takehara T, Koike K, Matsuura Y, Okamoto T.
    • Journal Title

      Proc Natl Acad Sci U S A.

      Volume: 118(22) Issue: 22 Pages: 2026184118-2026184118

    • DOI

      10.1073/pnas.2026184118

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Transcriptomics Identify Thrombospondin-2 as a Biomarker for Nonalcoholic Steatohepatitis and Advanced Liver Fibrosis2021

    • Author(s)
      Kozumi K, Kodama T, Murai H, Sakane S, Govaere O, Cockell S, Motooka D, Kakita N, Yamada Y, Kondo Y, Tahata Y, Yamada R, Hikita H, Sakamori R, Kamada Y, Daly KA, Anstee MQ, Tatsumi T, Morii E, Takehara T
    • Journal Title

      Hepatology

      Volume: 74(5) Issue: 5 Pages: 2452-2466

    • DOI

      10.1002/hep.31995

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] White Adipose Tissue Autophagy and Adipose-Liver Crosstalk Exacerbate Nonalcoholic Fatty Liver Disease in Mice2021

    • Author(s)
      Sakane Sadatsugu、Hikita Hayato、Shirai Kumiko、Myojin Yuta、Sasaki Youichi、Kudo Shinnosuke、Fukumoto Kenji、Mizutani Naoki、Tahata Yuki、Makino Yuki、Yamada Ryoko、Kodama Takahiro、Sakamori Ryotaro、Tatsumi Tomohide、Takehara Tetsuo
    • Journal Title

      Cellular and Molecular Gastroenterology and Hepatology

      Volume: 12 Issue: 5 Pages: 1683-1699

    • DOI

      10.1016/j.jcmgh.2021.07.008

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sleeping Beauty Transposon Mutagenesis Identifies Genes Driving the Initiation and Metastasis of Uterine Leiomyosarcoma2021

    • Author(s)
      Kodama Michiko、Shimura Hiroko、Tien Jean C.、Newberg Justin Y.、Kodama Takahiro、Wei Zhubo、Rangel Roberto、Yoshihara Kosuke、Kuruma Airi、Nakae Aya、Hashimoto Kae、Sawada Kenjiro、Kimura Tadashi、Jenkins Nancy A.、Copeland Neal G.
    • Journal Title

      Cancer Research

      Volume: 81 Issue: 21 Pages: 5413-5424

    • DOI

      10.1158/0008-5472.can-21-0356

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Hepatic Stellate Cells in Hepatocellular Carcinoma Promote Tumor Growth Via Growth Differentiation Factor 15 Production2021

    • Author(s)
      Myojin Y, Hikita H, Sugiyama M, Sasaki Y, Fukumoto K, Sakane S, Makino Y, Takemura N, Yamada R, Shigekawa M, Kodama T, Sakamori R, Kobayashi S, Tatsumi T, Suemizu H, Eguchi H, Kokudo N, Mizokami M, Takehara T.
    • Journal Title

      Gastroenterology .

      Volume: 160 Issue: 5 Pages: 1741-1754

    • DOI

      10.1053/j.gastro.2020.12.015

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Gab1 in livers with persistent hepatocyte apoptosis has an antiapoptotic effect and reduces chronic liver injury, fibrosis and tumorigenesis2021

    • Author(s)
      Mizutani N, Hikita H, Saito Y, Myojin Y, Sato K, Urabe M, Kurahashi T, Shiode Y, Sakane S, Murai K, Nozaki Y, Kodama T, Sakamori R, Yoshida Y, Tatsumi T, Takehara T.
    • Journal Title

      Am J Physiol Gastrointest Liver Physiol.

      Volume: in press Issue: 6 Pages: G958-G968

    • DOI

      10.1152/ajpgi.00370.2020

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Persistent hepatocyte apoptosis promotes tumorigenesis from diethylnitrosamine-transformed hepatocytes through increased oxidative stress, independent of compensatory liver regeneration2021

    • Author(s)
      Nozaki Y, Hikita H, Tanaka S, Fukumoto K, Urabe M, Sato K, Myojin Y, Doi A, Murai K, Sakane S, Saito Y, Kodama T, Sakamori R, Tatsumi T, Takehara T.
    • Journal Title

      Sci Rep

      Volume: 11 Issue: 1 Pages: 3363-3363

    • DOI

      10.1038/s41598-021-83082-7

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Sequential administration of XPO1 and ATR inhibitors enhances therapeutic response in TP53-mutated colorectal cancer2021

    • Author(s)
      Inoue A, Robinson FS, Minelli R, Tomihara H, Rizi BS, Rose JL, Kodama T, Srinivasan S, , Stephan C, Giuliani V, Deem AK, Shingu T, Deribe YL, Menter DG, Heffernan TP, Viale A, Bristow CA, Kopetz S, Draetta GF, Genovese G, Carugo A
    • Journal Title

      Gastroenterology

      Volume: in press Issue: 1 Pages: 196-210

    • DOI

      10.1053/j.gastro.2021.03.022

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] ST6GAL1 Is a Novel Serum Biomarker for Lenvatinib-Susceptible FGF19-Driven Hepatocellular Carcinoma2020

    • Author(s)
      Myojin Yuta、Kodama Takahiro、Maesaka Kazuki、Motooka Daisuke、Sato Yu、Tanaka Satoshi、Abe Yuichi、Ohkawa Kazuyoshi、Mita Eiji、Hayashi Yoshito、Hikita Hayato、Sakamori Ryotaro、Tatsumi Tomohide、Taguchi Ayumu、Eguchi Hidetoshi、Takehara Tetsuo
    • Journal Title

      Clinical Cancer Research

      Volume: 27 Issue: 4 Pages: 1150-1161

    • DOI

      10.1158/1078-0432.ccr-20-3382

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Presentation] 個別化医療を目指したがんゲノム・トランスクリプトーム解析による肝細胞癌層別化の試み2022

    • Author(s)
      村井大毅 小玉尚宏 竹原徹郎
    • Organizer
      第108回消化器病学会総会
    • Related Report
      2022 Annual Research Report
  • [Presentation] マルチオミクス解析による非B非C肝癌の分子免疫分類の構築2022

    • Author(s)
      村井大毅 小玉尚宏 竹原徹郎
    • Organizer
      第58回日本肝臓学会総会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Multiomics profiling identifies the link between intratumoral steatosis and immune-exhausted immunotherapy-susceptible tumor immune microenvironment in HCC2022

    • Author(s)
      Takahiro Kodama, Hiroki Murai, Tetsuo Takehara
    • Organizer
      APASL Oncology 2022
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] Intratumoral steatosis is an imaging biomarker for immunotherapy-susceptibility in HCC2022

    • Author(s)
      村井大毅 小玉尚宏 竹原徹郎
    • Organizer
      第81回日本癌学会学術総会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Understanding of tumor immune microenvironment in non-viral HCC through multi-omics and spatial transcriptomics2022

    • Author(s)
      小玉尚宏
    • Organizer
      JDDW2022
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] マルチオミクス解析による非B非C型肝癌の腫瘍免疫微小環境解析2022

    • Author(s)
      村井大毅 小玉尚宏 竹原徹郎
    • Organizer
      JDDW2022
    • Related Report
      2022 Annual Research Report
  • [Presentation] MRI is an imaging biomarker to diagnose steatotic HCC susceptible to combination immunotherapy for advanced HCC patients2022

    • Author(s)
      Hiroki Murai, Takahiro Kodama,Tetsuo Takehara
    • Organizer
      AASLD The Liver Meeting
    • Related Report
      2022 Annual Research Report
  • [Presentation] Serum ST6GAL1 is a novel biomarker for predicting efficacy of tyrosine kinase inhibitors in hepatocellular carcinoma by detecting FGF19 expressing tumor2021

    • Author(s)
      Yuta Myojin, Takahiro Kodama, Hayato Hikita, Ryotaro Sakamori, Tomohide Tatsumi, Tetsuo Takehara
    • Organizer
      AACR ANNUAL MEETING 2021
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 肝細胞癌薬物療法効果予測バイオマーカーとしての血清ST6GAL1の有用性2021

    • Author(s)
      小玉 尚宏、巽 智秀、竹原 徹郎
    • Organizer
      第57回日本肝臓学会総会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Multi-omics解析による非B非C肝癌の分子・免疫学的プロファイリング2021

    • Author(s)
      村井大毅、小玉 尚宏、竹原徹郎
    • Organizer
      第57回日本肝臓学会総会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Traf3による分化転換を介した肝内胆管癌発症機構の解明2021

    • Author(s)
      塩出悠登、小玉 尚宏、竹原徹郎
    • Organizer
      第57回日本肝臓学会総会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Biomarker-driven precision medicine for hepatocellular carcinoma2021

    • Author(s)
      Takahiro Kodama, Yuta Myojin, Hayato Hikita, Ryotaro Sakamori, Tomohide Tatsumi, Tetsuo Takehara
    • Organizer
      第80回日本癌学会学術総会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] マウス生体内トランスポゾン挿入変異スクリーニングによる胆管がん発症機構の解明2021

    • Author(s)
      小玉 尚宏、塩出悠登、竹原徹郎
    • Organizer
      第94回日本生化学会大会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] Molecular and immunological profiling for biomarker discovery in NAFLD-HCC2021

    • Author(s)
      Takahiro Kodama, Hiroki Murai, Tetsuo Takehara
    • Organizer
      第25回日本肝臓学会大会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] Discovery of non-viral Hepatocellular Carcinoma Immunomolecular Subtype through Cancer Genome and Transcriptome Analysis2021

    • Author(s)
      Hiroki Murai, Takahiro Kodama, Tetsuo Takehara
    • Organizer
      第25回日本肝臓学会大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Multiomics profiling identifies the pro-tumoral immune networks in the steatotic tumor microenvironment in non-viral hepatocellular carcinoma2021

    • Author(s)
      Hiroki Murai, Takahiro Kodama, Tetsuo Takehara
    • Organizer
      AASLD The Liver Meeting 2021
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] TRAF3 inactivation promotes intrahepatic cholangiocarcinoma development via NIK-mediated hepatocyte transdifferentiation2021

    • Author(s)
      Yuto Shiode, Takahiro Kodama, Ryoko Yamada, Hayato Hikita, Ryotaro Sakamori, Tomohide Tatsumi, Tetsuo Takehara
    • Organizer
      AASLD The Liver Meeting 2021
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 非B非C肝細胞癌の背景肝疾患別臨床的及び分子生物学的特徴の検討2020

    • Author(s)
      村井大毅、小玉尚宏、竹原徹郎
    • Organizer
      第106回日本消化器病学会総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 非B非C肝癌の臨床的特徴とNAFLDからの肝癌発症早期診断マーカーの検討2020

    • Author(s)
      村井大毅、小玉尚宏、竹原徹郎
    • Organizer
      第56回肝臓学会総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Hepatic stellate cell autophagy promotes HCC progression via GDF152020

    • Author(s)
      Yuta Myojin, Hayato Hikita, Masaya Sugiyama, Takahiro Kodama, Yuki Makino, Ryoko Yamada, Tasuku Nakabori, Ryotaro Sakamori, Tomohide Tatsumi, Masashi Mizokami, Tetsuo Takehara
    • Organizer
      The Digital International Liver Congress of the European Association for the Study of the Liver (EASL)
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] プール型CRISPRライブラリーを用いたNASH新規治療標的分子の網羅的探索2020

    • Author(s)
      明神悠太、小玉尚宏、竹原徹郎
    • Organizer
      第56回肝臓学会総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Genome-wide pooled CRISPR library screen identifies genetic mediators of hepatocyte lipotoxicity2020

    • Author(s)
      Takahiro Kodama, Yuta Myojin, Tetsuo Takehara
    • Organizer
      第24回日本肝臓学会大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Molecular and immunological profiling of non-viral hepatocellular carcinoma through multi-omics approach2020

    • Author(s)
      Hiroki Murai, Takahiro Kodama, Shoichiro Tange, Ryoko Yamada, Hayato Hikita, Ryotaro Sakamori, Tomohide Tatsumi, Tetsuo Takehara
    • Organizer
      The Liver Meeting Digital Experience (TLMdX)
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Serum ST6GAL1 is a novel biomarker for predicting efficacy of tyrosine kinase inhibitors in hepatocellular carcinoma2020

    • Author(s)
      Yuta Myojin, Takahiro Kodama, Kazuki Maesaka, Yu Sato, Hayato Hikita, Ryotaro Sakamori, Tomohide Tatsumi, Tetsuo Takehara
    • Organizer
      The Liver Meeting Digital Experience (TLMdX)
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 非B非C肝細胞癌の臨床的および分子生物学的特徴と予後に関する検討2020

    • Author(s)
      村井大毅、小玉尚宏、竹原徹郎
    • Organizer
      第56回日本肝癌研究会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Identification and functional analysis of UBE2D3, a novel tumor suppressor gene of hepatocellular carcinoma2020

    • Author(s)
      Hiroki Murai, Takahiro Kodama, Ryoko Yamada, Hayato Hikita, Ryotaro Sakamori, Tomohide Tatsumi, Tetsuo Takehara
    • Organizer
      The Liver Meeting Digital Experience (TLMdX)
    • Related Report
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    • Int'l Joint Research
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    • Author(s)
      Kodama T., Takehara T.
    • Total Pages
      620
    • Publisher
      Springer
    • ISBN
      9783030517090
    • Related Report
      2020 Annual Research Report
  • [Patent(Industrial Property Rights)] 免疫チェックポイント阻害剤に対する感受性の検査方法2022

    • Inventor(s)
      小玉尚宏、村井大毅、竹原徹郎
    • Industrial Property Rights Holder
      小玉尚宏、村井大毅、竹原徹郎
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2022-074111
    • Filing Date
      2022
    • Related Report
      2022 Annual Research Report
  • [Patent(Industrial Property Rights)] 成熟肝細胞の分化転換抑制用組成物2021

    • Inventor(s)
      小玉尚宏、塩出悠登、竹原徹郎
    • Industrial Property Rights Holder
      小玉尚宏、塩出悠登、竹原徹郎
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2021-135496
    • Filing Date
      2021
    • Related Report
      2021 Annual Research Report
  • [Patent(Industrial Property Rights)] 癌に関連する新規バイオマーカー2020

    • Inventor(s)
      小玉尚宏、明神悠太、竹原徹郎
    • Industrial Property Rights Holder
      小玉尚宏、明神悠太、竹原徹郎
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2020-165604
    • Filing Date
      2020
    • Related Report
      2020 Annual Research Report

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Published: 2020-04-28   Modified: 2024-01-30  

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