The Role of Reactive Sulfur Species in Refractory Respiratory Diseases

• Project/Area Number: 20H03684
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Review Section: Basic Section 53030:Respiratory medicine-related
• Research Institution: Tohoku University
• Principal Investigator: SUGIURA Hisatoshi 東北大学, 医学系研究科, 教授 (20445092)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Project Status: Completed (Fiscal Year 2022)
• Budget Amount: ¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000); Fiscal Year 2022: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2021: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000); Fiscal Year 2020: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
• Keywords: 活性硫黄分氏種 / 酸化ストレス / 慢性閉塞性肺疾患 / 組織障害 / 間質性肺炎 / 活性硫黄分子種 / 組織保護 / 組織傷害

Outline of Research at the Start

本研究の目的は慢性閉塞性肺疾患(COPD)や間質性肺炎(IP)といった難治性呼吸器疾患動物モデルを作成し、新規に発見した活性硫黄分子種(RSS)の役割を明らかにするために産生酵素であるCARS2遺伝子欠損マウスやRSS供与体を用いて、病態に及ぼす作用を個体レベルで明らかにすることである。またCOPD患者の肺組織・細胞及び喀痰を採取し、肺細胞内外におけるCARS2の発現やRSS含有量を測定する。大規模COPD患者コホートを用いて、RSSの気道における産生量と臨床病態(呼吸機能や身体活動性の経年低下、増悪回数)との関連を前向き研究で明らかにする。

Outline of Final Research Achievements

This study elucidated the role of the reactive species (RSS) in refractory respiratory disease.
Mice heterozygous for the CARS2 gene, the enzyme responsible for the production of RSS, showed exacerbation of emphysema lesions by elastase or tobacco smoke extract. In vitro studies of lung constructs showed that RSS was important for suppressing inflammatory cytokine production, reducing oxidative stress, and inhibiting cellular senescence. COPD-derived lung constructs showed decreased expression of CARS2, which was associated with respiratory function. In a bleomycin-induced pulmonary fibrosis model, CARS2-deficient mice showed worsening of fibrotic lesions.

Academic Significance and Societal Importance of the Research Achievements

COPDをはじめとする難治性呼吸器疾患の病態は不明な点が多く、肺の抗酸化分子の観点からの研究は少ない。我々は肺における活性硫黄分子種(reactive sulfur species: RSS)の存在を明らかにした。RSSの産生酵素であるCARS2のヘテロ欠損マウスを作成し、このマウスを元にCOPDモデル及び肺線維症モデルマウスを作成し検討したところ野生型と比較して欠損マウスでは各疾患モデルの病態の悪化が認められた。さらにCOPD患者由来の肺組織、肺細胞ではCARS2の発現が低下し、肺の呼吸機能とも関連することを明らかにした。以上より難治性呼吸器疾患の病態改善に寄与する可能性が示唆された。

Research Products

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  • Author(s): Itakura Koji、Fujino Naoya、Kamide Yosuke、Saito Ikuo、Yamada Mitsuhiro、Okutomo Koji、Tsukita Yoko、Saito Takuya、Ichikawa Tomohiro、Numakura Tadahisa、Kyogoku Yorihiko、Aizawa Hiroyuki、Ono Yoshinao、Matsumoto Shuichiro、Hussell Tracy、Taniguchi Masami、Ichinose Masakazu、Sugiura Hisatoshi
  • Journal Title: Allergology International Volume: 71 Issue: 3 Pages: 383-394
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• [Journal Article] Triple versus LAMA/LABA combination therapy for Japanese patients with COPD: A systematic review and meta-analysis (2022)
  • Author(s): Koarai Akira、Yamada Mitsuhiro、Ichikawa Tomohiro、Fujino Naoya、Kawayama Tomotaka、Sugiura Hisatoshi
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• [Journal Article] Urine autotaxin levels reflect the disease activity of sarcoidosis (2022)
  • Author(s): Murakami Koji、Tamada Tsutomu、Saigusa Daisuke、Miyauchi Eisaku、Nara Masayuki、Ichinose Masakazu、Kurano Makoto、Yatomi Yutaka、Sugiura Hisatoshi
  • Journal Title: Scientific Reports Volume: 12 Issue: 1 Pages: 4372-4372
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• [Journal Article] Clinical features of COVID-19 patients with rebound phenomenon after corticosteroid therapy (2022)
  • Author(s): Murakami Koji、Sano Hirohito、Tode Naoki、Tsukita Yoko、Sato Kei、Narita Daisuke、Kimura Nozomu、Matsumoto Shuichiro、Ono Yoshinao、Iwasaki Chikashi、Sugiyama Hatsumi、Suzuki Manami、Kakuto Sho、Konno Shuichi、Kanamori Hajime、Baba Hiroaki、Oshima Kengo、Takei Kentarou、Tokuda Koichi、Tamada Tsutomu、Sugiura Hisatoshi
  • Journal Title: BMJ Open Respiratory Research Volume: 9 Issue: 1 Pages: e001332-e001332
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• [Journal Article] Increased LHX9 expression in alveolar epitherial type 2 cells of patients with chronic obstructive pulmonary disease. (2022)
  • Author(s): Okutomo K. Fujino N, Yamada M, Saito T,Ono Y,Okada Y, Ichinose M, Sugiura H
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• [Journal Article] COVID-19 in a Hairy Cell Leukemia Patient: A Rare Case Report (2022)
  • Author(s): Sano H, Murakami K, Yokoyama H, Suzuki C, Iwasaki Y, Kodama E, Sugiura H
  • Journal Title: The Tohoku Journal of Experimental Medicine Volume: 258 Issue: 1 Pages: 63-68
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• [Journal Article] The efficacy profiles of concurrent chemoradiotherapy with intensity-modulated radiotherapy followed by durvalumab in patients with unresectable stage Ⅲ non- smaii cell lung cancer: A multicenter retrospective cohort study. (2022)
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• [Journal Article] The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force (2022)
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  • Journal Title: Nature Communications Volume: 13 Issue: 1 Pages: 4830-4830
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• [Journal Article] 成人喘息の診断・管理のためのバイオマーカー (2022)
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• [Journal Article] Ⅳ．COPD診断へのアプローチ COPDにおける併存症総論． (2022)
  • Author(s): 藤野直也、杉浦久敏
  • Journal Title: 日本臨牀 Volume: 80（6） Pages: 246-251
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• [Journal Article] 今月の症例 肉芽腫を超えて肺胞腔への進展を示したコクシジオイデス症の1例． (2022)
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  • Journal Title: 日本内科学会雑誌 Volume: 111（7） Pages: 246-251
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• [Journal Article] The Clinical Features of Patients with Sarcoidosis and Malignant Diseases in Japan (2021)
  • Author(s): Tamada T, Nara M, Murakami K, Gamo S, Aritake H, Shimizu M, Kazama I, Ichinose M and Sugiura H.
  • Journal Title: Internal Medicine Volume: 60 Issue: 2 Pages: 209-216
  • DOI: 10.2169/internalmedicine.5441-20
  • NAID: 130007968940
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  • Year and Date: 2021-01-15
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• [Journal Article] ACO (Asthma COPD Overlap) Is Independent from COPD, a Case in Favor: A Systematic Review (2021)
  • Author(s): Fujino Naoya、Sugiura Hisatoshi
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• [Journal Article] A Prospective Cohort Study to Assess Obstructive Respiratory Disease Phenotypes and Endotypes in Japan: The TRAIT Study Design. (2021)
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  • Journal Title: Int J Chron Obstruct Pulmon Dis. Volume: 16 Pages: 1813-1822
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• [Journal Article] Triple versus LAMA/LABA combination therapy for patients with COPD: A systematic review and meta-analysis (2021)
  • Author(s): Koarai Akira、Yamada Mitsuhiro、Ichikawa Tomohiro、Fujino Naoya、Kawayama Tomotaka、Sugiura Hisatoshi
  • Journal Title: Respir Res Volume: 22 Issue: 1 Pages: 183-183
  • DOI: 10.1186/s12931-021-01777-x
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• [Journal Article] Upregulation of leukocyte immunoglobulin-like receptor B4 on interstitial macrophages in COPD; their possible protective role against emphysema formation. (2021)
  • Author(s): Mitsune A, Yamada M, Fujino N, Numakura T, Ichikawa T, Suzuki A, Matsumoto S, Mitsuhashi Y, Itakura K, Makiguchi T, Koarai A, Tamada T, Endo S, Takai T, Okada Y, Suzuki S, Ichinose M, Sugiura H.
  • Journal Title: Respir Res Volume: 22 Issue: 1 Pages: 232-232
  • DOI: 10.1186/s12931-021-01828-3
  • Peer Reviewed / Open Access
• [Journal Article] Corrections to: Efficacy of budesonide/glycopyrronium/formoterol metered dose inhaler in patients with COPD: post-hoc analysis from the KRONOS study excluding patients with airway reversibility and high eosinophil counts． (2021)
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  • Journal Title: Respir Res. Volume: 22 Issue: 1 Pages: 223-223
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• [Journal Article] Efficacy of budesonide/glycopyrronium/formoterol metered dose inhaler in patients with COPD: post-hoc analysis from the KRONOS study excluding patients with airway reversibility and high eosinophil counts (2021)
  • Author(s): Muro S, Sugiura H, Darken P, Dorinsky P.
  • Journal Title: Respir Res. Volume: 22 Issue: 1 Pages: 187-187
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• [Journal Article] Longitudinal Relationship Between Growth Differentiation Factor 11 and Physical Activity in Chronic Obstructive Pulmonary Disease (2021)
  • Author(s): Tanaka Rie、Koarai Akira、Yamada Mitsuhiro、Fujino Naoya、Ichikawa Tomohiro、Numakura Tadahisa、Onodera Katsuhiro、Kyogoku Yorihiko、Tamada Tsutomu、Miura Motohiko、Minakata Yoshiaki、Ichinose Masakazu、Sugiura Hisatoshi
  • Journal Title: International Journal of Chronic Obstructive Pulmonary Disease Volume: Volume 16 Pages: 999-1006
  • DOI: 10.2147/copd.s301690
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• [Journal Article] Genetic loci for lung function in Japanese adults with adjustment for exhaled nitric oxide levels as airway inflammation indicator (2021)
  • Author(s): Yamada Mitsuhiro et al.
  • Journal Title: Communications Biology Volume: 4 Issue: 1 Pages: 1288-1288
  • DOI: 10.1038/s42003-021-02813-8
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• [Journal Article] Intensity-modulated radiation therapy with concurrent chemotherapy followed by durvalumab for stage III non-small cell lung cancer: A multi-center retrospective study. (2021)
  • Author(s): Tsukita Y, Yamamoto T, Mayahara H, Hata A, Takeda Y, Nakayama H, Tanaka S, Uchida J, Usui K, Toyoda T, Tamiya M, Morimoto M, Oya Y, Kodaira T, Miyauchi E, Jingu K, Sugiura H.
  • Journal Title: Radiother Oncol. Volume: 160 Pages: 266-272
  • DOI: 10.1016/j.radonc.2021.05.016
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• [Journal Article] An official JRS statement: The principles of fractional exhaled nitric oxide (FeNO) measurement and interpretation of the results in clinical practice (2021)
  • Author(s): Matsunaga Kazuto、Kuwahira Ichiro、Hanaoka Masayuki、Saito Junpei、Tsuburai Takahiro、Fukunaga Koichi、Matsumoto Hisako、Sugiura Hisatoshi、Ichinose Masakazu
  • Journal Title: Respiratory Investigation Volume: 59 Issue: 1 Pages: 34-52
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• [Journal Article] PGC-1α regulates airway epithelial barrier dysfunction induced by house dust mite (2021)
  • Author(s): Saito Tsutomu、Ichikawa Tomohiro、Numakura Tadahisa、Yamada Mitsuhiro、Koarai Akira、Fujino Naoya、Murakami Koji、Yamanaka Shun、Sasaki Yusaku、Kyogoku Yorihiko、Itakura Koji、Sano Hirohito、Takita Katsuya、Tanaka Rie、Tamada Tsutomu、Ichinose Masakazu、Sugiura Hisatoshi
  • Journal Title: Respiratory Research Volume: 22 Issue: 1 Pages: 63-63
  • DOI: 10.1186/s12931-021-01663-6
  • Peer Reviewed / Open Access
• [Journal Article] The Clinical Features of Patients with Sarcoidosis and Malignant Disease in Japan. (2021)
  • Author(s): Tamada T, Nara M, Murakami K, Gamo S, Aritake H, Shimizu M, Kazama I,Ichinose M, Sugiura H
  • Journal Title: Intern Med Volume: 60 Pages: 209-216
  • NAID: 130007968940
  • Peer Reviewed / Open Access
• [Journal Article] Negative heart signを呈した肺サルコイドーシスの1例 (2021)
  • Author(s): 鈴木歩、藤野直也、平野泰三、村上康司、玉田勉、杉浦久敏
  • Journal Title: 日本呼吸器学会誌 Volume: 10 Pages: 78-82
  • Peer Reviewed
• [Journal Article] Treatment with LABA versus LAMA for stable COPD: a systematic review and meta-analysis. (2020)
  • Author(s): Koarai A, Sugiura H, Yamada M, Ichikawa T, Fujino N, Kawayama T, Ichinose M.
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• [Journal Article] A case of localized tracheobronchial relapsing polychondritis with positive matrilin-1 staining. (2020)
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• [Journal Article] A case of bronchial asthma in a younger patient with vocal cord dysfunction. (2020)
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  • NAID: 130007877456
• [Journal Article] Decreased expression of a phagocytic receptor Siglec-1 on alveolar macrophages in chronic obstructive pulmonary disease (2020)
  • Author(s): Tanno Atsushi、Fujino Naoya、Yamada Mitsuhiro、Sugiura Hisatoshi、Hirano Taizou、Tanaka Rie、Sano Hirohito、Suzuki Satoshi、Okada Yoshinori、Ichinose Masakazu
  • Journal Title: Respiratory Research Volume: 21 Issue: 1 Pages: 30-30
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• [Journal Article] 注目の新薬 ビレーズトリTMエアロスフィア○R（ブデソニド/グリコピロニウム臭化物/ホルモテロールフマル酸塩水和物製剤） (2020)
  • Author(s): 藤野直也、杉浦久敏
  • Journal Title: 診断と治療 Volume: 180 Pages: 263-266
• [Journal Article] 気管・気管支内に多発する転移結節を認めた小細胞肺癌の1例 (2020)
  • Author(s): 鈴木歩、宮内栄作、成田大輔、相澤洋之、東條裕、小林誠、村上康司、山田充啓、杉浦久敏、一ノ瀬正和
  • Journal Title: 気管支学 Volume: 42 Pages: 269-273
  • NAID: 130007856050
• [Presentation] 生物学的製剤使用重症喘息症例のclinical remissionに関する検討 (2023)
  • Author(s): 松本周一郎、藤野直也、小野祥直、鈴木眞奈美、今野周一、遠藤卓人、畠山哲八、大江 崇、佐野寛仁、京極自彦、相澤洋之、市川朋宏、山田充啓、小荒井晃、玉田 勉、杉浦久敏
  • Organizer: 第4回日本アレルギー学会東北地方会
• [Presentation] 肺構築細胞の細胞老化におけるGZMK および受容体PAR1 についての検討 (2023)
  • Author(s): 高根澤駿斗、沼倉 忠久，松本周一郎，山田 充啓，藤野 直也，市川 朋宏， 小荒井晃，玉田 勉，杉浦 久敏
  • Organizer: 第116回日本呼吸器学会東北地方会
• [Presentation] Reactive sulfur species regulate imｍuno response via T cell receptor signaling. (2022)
  • Author(s): Morita M, Yamada M, Sasaki Y, Numakura T, Ida T, Matsunaga T, Takata T, Watanabe A, Inaba K, Ishii N, Sugiura H, Moyohashi H, Akaike T
  • Organizer: The22nd Nitric oxide society of Japan
  • Int'l Joint Research
• [Presentation] COPD病態関連分子の解明を目指して (2022)
  • Author(s): 杉浦久敏
  • Organizer: 第62回日本呼吸器学会学術講演会
  • Invited
• [Presentation] COPDの病態と治療～ガイドライン第6版を踏まえて～ (2022)
  • Author(s): 杉浦久敏
  • Organizer: 第25回日本病院総合診療医学会学術総会
  • Invited
• [Presentation] COPD・肺気腫の病態と管理 (2022)
  • Author(s): 杉浦久敏
  • Organizer: 第75回日本胸部外科学会定期学術集会
  • Invited
• [Presentation] 酸化ストレスによる気道炎症ーレドックス関連分子の役割 (2022)
  • Author(s): 杉浦久敏
  • Organizer: 第71回日本アレルギー学会学術大会
  • Invited
• [Presentation] 2型自然リンパ球における活性イオウ分子種の役割についての検討 (2022)
  • Author(s): 鈴木 歩、沼倉忠久、山田充啓、松本潤一郎、佐々木優作、光根 歩、奥山祐子、石井直人、赤池孝章、一ノ瀬正和、杉浦久敏
  • Organizer: 第62回日本呼吸器学会学術講演会
• [Presentation] The Role of the Principal Cysteine Persulfide Synthase in the innate Immunity of Type 2 Airway Inflammation. (2021)
  • Author(s): Suzuki A, Numakura T, Yamada M, Sasaki Y, Tanaka R, Mitsune A, Okuyama Y, Ishii N, Akaike T, Ichinose M, Sugiura H
  • Organizer: 2021 ATS International Conference
  • Int'l Joint Research
• [Presentation] The role of 27-hydroxycholesterol in the pathogenesis of bronchial asthma. (2021)
  • Author(s): Ito T, Ichikawa T, Takita K, Yamada M, Ichinose M, Sugiura H
  • Organizer: 2021 ATS International Conference
  • Int'l Joint Research
• [Presentation] Siglec-1-negative alveolar Macrophages May Represent Pro-inflammatory Phenotypes And Associated with COPD Exacerbation. (2021)
  • Author(s): Saito T, Fujino N, Kyogoku Y, Okutomo K, Yamada M, Sugiura H
  • Organizer: 2021 ATS International Conference
  • Int'l Joint Research
• [Presentation] Effect of oxidative stress on the production of dsDNA-induced interferon in airway epithelial cells. (2021)
  • Author(s): Koarai A, Aizawa H, Numakura T, Ichikawa T, Fujino N, Yamada M, Sugiura H.
  • Organizer: The 25th Congress of the Asian Pacific Society of Respirology
  • Int'l Joint Research
• [Presentation] Role of reactive persulfide species in influenza virus-induced lung inflammation (2021)
  • Author(s): Ichikawa T, Takita K, Ito T, Kyogoku Y, Numakura T, Yamada M, Akaike T, Ichinose M, Sugiura H.
  • Organizer: The 25th Congress of the Asian Pacific Society of Respirology
  • Int'l Joint Research
• [Presentation] Reactive sulfur species are involved in the regulation of innate immunity of type 2 airway inflammation (2021)
  • Author(s): Suzuki A,Yamada M, Numakura T, Sasaki Y, Kyogoku Y, Tanaka R, Mitsune A, Matsumoto S, Okuyama Y,Ishii N, Akaike T, Ichinose M, Sugiura H.
  • Organizer: The 25th Congress of the Asian Pacific Society of Respirology
  • Int'l Joint Research
• [Presentation] Siglec-1-negative alveolar macrophages are associated with COPD exacerbation and may represent pro-inflammatory phenotypes (2021)
  • Author(s): Saito T, Fujino N, Kyogoku Y, Okutomo K, Yamada M, Sugiura H.
  • Organizer: The 25th Congress of the Asian Pacific Society of Respirology
  • Int'l Joint Research
• [Presentation] The role of 27-hydroxycholesterol in the pathogenesis of bronchial asthma. (2021)
  • Author(s): Ito T, Ichikawa T, Takita K, Yamada M, Sugiura H.
  • Organizer: The 25th Congress of the Asian Pacific Society of Respirology
  • Int'l Joint Research
• [Presentation] TLR3を介した酸化ストレスに対する活性硫黄分子種の抗酸化作用の検討 (2021)
  • Author(s): 市川朋宏、滝田克也、京極自彦、沼倉忠久、伊藤辰徳、山田充啓、赤池孝章、杉浦久敏
  • Organizer: 第61回日本呼吸器学会学術講演会
• [Presentation] 酸化ストレスのdsDNA刺激誘導性インターフェロン産生に与える影響検討 (2021)
  • Author(s): 小荒井晃、宍倉 裕、相澤洋之、沼倉忠久、市川朋宏、藤野直也、山田充啓、杉浦久敏
  • Organizer: 第61回日本呼吸器学会学術講演会
• [Presentation] 自然リンパ球を介した2型気道炎症における活性イオウ分子種産生酵素の役割 (2021)
  • Author(s): 鈴木 歩、沼倉忠久、山田充啓、佐々木優作、田中里江、奥山祐子、石井直人、赤池孝章、一ノ瀬正和、杉浦久敏
  • Organizer: 第61回日本呼吸器学会学術講演会
• [Presentation] ＣＤ4+Ｔ細胞の活性化における新規活性イオウ分子種産生酵素の役割解明 (2021)
  • Author(s): 沼倉忠久、山田充啓、佐々木優作、鈴木 歩、京極自彦、田中里江、赤池孝章、石井直人、一ノ瀬正和、杉浦久敏
  • Organizer: 第61回日本呼吸器学会学術講演会
• [Presentation] 慢性閉塞性肺疾患の増悪における肺胞マクロファージのSiglic-1発現低下 (2021)
  • Author(s): 齋藤拓矢、藤野直也、京極自彦、山田充啓、杉浦久敏
  • Organizer: 第61回日本呼吸器学会学術講演会
• [Presentation] COPD増悪頻回患者における血清細胞外小胞microRNAの発現プロファイル (2021)
  • Author(s): 山田充啓、牧口友紀、藤野直也、光根 歩、小林誠一、矢内 勝、一ノ瀬正和、杉浦久敏
  • Organizer: 第61回日本呼吸器学会学術講演会
• [Presentation] COPD増悪病態におけるレチノイン酸経路の関与の検討 (2021)
  • Author(s): 相澤洋之、小荒井晃、宍倉 裕、沼倉忠久、藤野直也、市川朋宏、山田充啓、杉浦久敏
  • Organizer: 第61回日本呼吸器学会学術講演会
• [Presentation] 気管支喘息の病態おける27-hydroxycholesterolの役割 (2021)
  • Author(s): 伊藤辰徳、市川朋宏、橋本裕一郎、滝田克也、一ノ瀬正和、杉浦久敏
  • Organizer: 第61回日本呼吸器学会学術講演会
• [Presentation] The role of 27-hydroxycholesterol in the pathogenesis of bronchial asthma. (2021)
  • Author(s): Ito T, Ichikawa T, Takita K, Yamada M, Ichinose M, Sugiura H.
  • Organizer: 第70回日本アレルギー学会学術大会
• [Presentation] The role of the principal cysteine persulfide synthase in the innate immunity of type 2 airway inflammation (2021)
  • Author(s): Suzuki A,Yamada M, Numakura T, Sasaki Y, Kyogoku Y, Tanaka R, Mitsune A, Okuyama Y, Ishii N, Akaike T, Ichinose M, Sugiura H
  • Organizer: 第70回日本アレルギー学会学術大会
• [Presentation] COPD治療におけるトリプル製剤の役割 (2020)
  • Author(s): 杉浦久敏
  • Organizer: JSA/WAO Joint Congress
  • Int'l Joint Research / Invited
• [Presentation] Low Birthweight Affects Predicted FEV1 in People in Their 20s; Factors Influencing Lung Function in adulthood Based on the Tohoku Medical Megabank Organization Community Health Survey (2020)
  • Author(s): Ohe T, Yamada M, Sugiura H, Mitsune A, Fuse N, Hozawa A, Nakamura T, Yamamoto M, Ichinose M.
  • Organizer: American Thoracic Society International Conference
  • Int'l Joint Research
• [Presentation] Sialic Acid-Binding Immunoglobulin-Type Lectin1 (Siglec1) Is Important for Bacterial Engulfment by Alveolar Macrophages and Is Down-Regulated in COPD Patients (2020)
  • Author(s): Fujino N, Tanno A, Yamada M, Sugiura H, Hirano T, Tanaka R, Sano H, Ichinose M
  • Organizer: American Thoracic Society International Conference
  • Int'l Joint Research
• [Presentation] Deficiency of CARS2, a principal cysteine persulfide synthase, aggravated house dust mite induced allergic inflammation in a mouse model of asthma (2020)
  • Author(s): Sasaki Y, Yamada M, Numakura T, Ida T, Morita M, Tanaka R, Fujino N, Ichikawa T, Okuyama Y, Ishii N, Akaike T, Sugiura H, Ichinose M
  • Organizer: ERS International Congress
  • Int'l Joint Research
• [Presentation] The clinical significance of plasma and urine lysophospholipids-producing enzyme in patients with sarcoidosis (2020)
  • Author(s): Murakami K, Tamada T, Saigusa D, Nara M, Miyauchi E, Aritake H, Gamo S, Sugiura H, Yatomi Y, Ichinose M
  • Organizer: ERS International Congress
  • Int'l Joint Research
• [Presentation] Long-acting bronchodilators improve lipopolysaccharide-induced swine airway hypersecretion as well as the abnormal acidificatiom in pH (2020)
  • Author(s): Aritake H, Tamada T, Murakami K, Gamo S, Nara M, Sugiura H, Ichinose M
  • Organizer: ERS International Congress
  • Int'l Joint Research
• [Presentation] Role of reactive persulfide species in influenza virus-induced lung inflammation in mice (2020)
  • Author(s): Takita K, Sugiura H, Ichikawa T, Numakura T, Hirano T, Yamada M, Akaike T, Ichinose M:Role of reactive persulfide species in influenza virus-induced lung inflammation in mice
  • Organizer: ERS International Congress
  • Int'l Joint Research
• [Presentation] Role of reactive persulfides in influenza A virus-induced oxidative stress． (2020)
  • Author(s): Ichikawa T, Takita K, Sugiura H, Numakura T, Akaike T, Ichinose M
  • Organizer: JSA/WAO Joint Congress
  • Int'l Joint Research
• [Presentation] Deficiency of a principal cysteine persulfide synthase aggravated airway allergic inflammation in a mouse model of asthma (2020)
  • Author(s): Sasaki Y , Numakura T, Yamada M, Suzuki A, Fujino N, Ichikawa T, Koarai A, Akaike T, Ishii N, Sugiura H, Ichinose M
  • Organizer: JSA/WAO Joint Congress
  • Int'l Joint Research
• [Presentation] 呼気NO測定－Up to Date (2020)
  • Author(s): 杉浦久敏
  • Organizer: 第60回日本呼吸器学会学術講演会
  • Invited
• [Presentation] COPDとACOの診断と治療 (2020)
  • Author(s): 杉浦久敏
  • Organizer: 日本呼吸器学会第41回生涯教育講演会
  • Invited
• [Presentation] 結腸気管支瘻による肺炎，肺膿瘍に対して気管支充填術を施行し救命し得た一例 (2020)
  • Author(s): 鈴木歩、小荒井晃、川副友、宮内栄作、東出直樹、片平真人、佐渡哲、杉浦久敏、一ノ瀬正和
  • Organizer: 第43回日本呼吸器内視鏡学会学術集会
• [Presentation] ALK-IHC陽性肺腺癌に対してアレクチニブを投与したが奏効せず、後にROS1陽性が判明しクリゾチニブが奏功した一例 (2020)
  • Author(s): 杉山初美、宮内栄作、齊藤涼子、齋藤勉、相澤洋之、突田容子、齋藤良太、佐藤輝幸、宍倉裕、杉浦久敏
  • Organizer: 第59回日本肺癌学会東北支部会
• [Presentation] 髄膜癌腫瘍を伴う小細胞肺癌に対する全脳照射の有効性に関する検討 (2020)
  • Author(s): 鈴木歩、宮内栄作、相澤洋之、突田容子、東出直樹、齋藤良太、佐藤輝幸、杉浦久敏、一ノ瀬正和
  • Organizer: 第111回日本呼吸器学会東北地方会
• [Presentation] 肺癌との鑑別を要した肺骨形成の一例 (2020)
  • Author(s): 杉山初美、宮内栄作、宍倉裕、佐藤聡子、鈴木隆哉、岡田克典、杉浦久敏
  • Organizer: 第111回日本呼吸器学会東北地方会
• [Presentation] 新鮮ブタ気道分泌液pHに対する長時間作用性β2刺激薬（LABA）の影響 (2020)
  • Author(s): 有竹秀美、玉田勉、村上康司、蒲生俊一、奈良正之、杉浦久敏、一ノ瀬正和
  • Organizer: 第60回日本呼吸器学会学術講演会
• [Presentation] インフルエンザウイルス感染における活性硫黄分子種の抗酸化作用の検討 (2020)
  • Author(s): 滝田克也、杉浦久敏、市川朋宏、沼倉忠久、山田充啓、平野泰三、赤池孝章、一ノ瀬正和
  • Organizer: 第60回日本呼吸器学会学術講演会
• [Presentation] 2型気道炎症における活性イオウ分子種新規産生酵素の役割 (2020)
  • Author(s): 佐々木優作、沼倉忠久、山田充啓、杉浦久敏、守田匡伸、赤池孝章、一ノ瀬正和
  • Organizer: 第60回日本呼吸器学会学術講演会
• [Presentation] 喘息特徴のないCOPD患者に対する共懸濁技術を用いた定量吸入器によるブデソニド／グリコピロニウム／ホルモテロール（BGF MDI）の有効性 (2020)
  • Author(s): 室繁郎、杉浦久敏、Partrick Darken,Paul Dorinsky
  • Organizer: 第60回日本呼吸器学会学術講演会
• [Presentation] 日本における閉塞性肺疾患のフェノタイプおよびエンドタイプを評価する前向きコホート研究：TRAIT studyのデザイン (2020)
  • Author(s): 檜澤伸之、加藤元一、福永興壱、杉浦久敏、杉山祐太郎、花澤智大、貝瀬俊彦、Ruth Tal-Singer、P Jones, Neil Barnes,Chris Compton, 石井健男
  • Organizer: 第60回日本呼吸器学会学術講演会
• [Presentation] 肉芽腫を超えて肺胞腔への進展を示したコクシジオイデス症の１例 (2020)
  • Author(s): 佐野寛仁、藤野直也、齊藤涼子、山田充啓、玉田勉、亀井克彦、杉浦久敏
  • Organizer: 第222回日本内科学会東北地方会
• [Presentation] 著名な骨破壊を伴い、脊椎悪性疾患との鑑別を要した骨サルコイドーシスの１例 (2020)
  • Author(s): 木村望、村上康司、山中駿、突田容子、玉田勉、杉浦久敏
  • Organizer: 第222回日本内科学会東北地方会
• [Presentation] 両側胸水と大量ンの腹水を認め診断医苦渋した結核性胸腹膜炎の一例 (2020)
  • Author(s): 松本周一郎、宍倉裕、伊藤辰徳、佐藤輝幸、村上康司、杉浦久敏
  • Organizer: 第112回日本呼吸器学会東北地方会
• [Book] 最新ガイドラインに基づく呼吸器疾患診療指針2023－'24 (2022)
  • Author(s): 小荒井 晃、杉浦久敏
  • Total Pages: 6
  • Publisher: 総合医学社
• [Book] 日常診療に活かす 診療ガイドラインUP-TO-DATE 2022-2023 (2022)
  • Author(s): 小荒井 晃、杉浦久敏
  • Total Pages: 1
  • Publisher: メディカルレビュー社
• [Book] 呼吸器疾患最新の治療 2022－2024 (2022)
  • Author(s): 小荒井 晃、杉浦久敏
  • Total Pages: 1
  • Publisher: 南江堂
• [Book] 慢性疾患治療薬の使い分けと患者モニタリング (2020)
  • Author(s): 藤野直也、杉浦久敏
  • Total Pages: 312
  • Publisher: じほう