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Cross-sectional and prospective study with metabolome analysis to detect pathophysiology about the relationship between deterioration in lung function and sleep disordered breathing

Research Project

Project/Area Number 20H03690
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 53030:Respiratory medicine-related
Research InstitutionKyoto University

Principal Investigator

Chin Kazuo  京都大学, 医学研究科, 研究員 (90197640)

Co-Investigator(Kenkyū-buntansha) 松田 文彦  京都大学, 医学研究科, 教授 (50212220)
平井 豊博  京都大学, 医学研究科, 教授 (20359805)
田原 康玄  静岡社会健康医学大学院大学, 社会健康医学研究科, 教授 (00268749)
森田 智視  京都大学, 医学研究科, 教授 (60362480)
中山 健夫  京都大学, 医学研究科, 教授 (70217933)
若村 智子  京都大学, 医学研究科, 教授 (40240452)
松本 久子  京都大学, 医学研究科, 准教授 (60359809)
Project Period (FY) 2020-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2022: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2021: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
Fiscal Year 2020: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
Keywords睡眠呼吸障害 / 睡眠時無呼吸 / 慢性閉塞性肺疾患 / メタボローム / 前向き検討 / 生活習慣病 / 糖尿病 / 高血圧 / 糖尿病家族歴
Outline of Research at the Start

肺機能低下および睡眠呼吸障害(SDB)のいずれもが、心血管障害、代謝障害を誘導し、予後に影響を与える。COPDとSDBの合併はoverlap症候群とされ、COPD単独よりも予後悪化が報告されているが本邦の資料は乏しい。7000名以上の世界最大規模のSDBを含む客観的な睡眠関連と肺機能資料を用いて単独、合併の生活習慣病への関連のみならず影響をみる学術的独自性の高い研究の完結を目指すとともに、メタボローム解析を通じて病態生理の解明とバイオマーカ―探索という創造性も保持している。

Outline of Final Research Achievements

In the Nagahama cohort, we gathered almost 8,000 participants' data of sleep disordered breathing (SDB) and objective sleep duration by actigraph. We reported that 1)metabolic comorbidities such as diabetes and hypertension contribute to SDB regardless of the degree of obesity, 2)among the a family history of diabetes-positive participants, the prevalence of recent-onset diabetes was higher in those with moderate to severe-SDB than those without SDB, but only in females, 3) SDB and office systolic blood pressure were independently and synergistically associated with the increase urinary albumin excretion, which is considered a risk factor for chronic kidney disease and cardiovascular events, 4)an association between the prevalence of SDB and HbA1c level even within or over the normal range was found only in patients without antidiabetic treatment and was more prominent in the middle-aged and in women. Thus, the close relationships between SDB and lifestyle diseases were showed.

Academic Significance and Societal Importance of the Research Achievements

「ながはま」コホートの資料から、成人男性の中等症以上のSDB(ほとんどが閉塞性睡眠時無呼吸:OSA)は23.7%、閉経前女性1.5%、閉経後女性は9.5%であった。本コホートはアジア最大、世界2番目のSDBの調査となった。また、客観的睡眠時間測定数は世界最大数であった。これら大規模疫学研究より、SDB(OSA)が肥満と関連無しで、高血圧、糖尿病、尿中アルブミン尿などの生活習慣病とSDBが関連し、高血圧、糖尿病では相互関連も明らかになった。肥満と高血圧、糖尿病が合併すると中等度以上のSDBは合併者の40%以上になったので。生活習慣病(特に肥満合併例)の管理においては、SDBの管理も重要である。

Report

(4 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Annual Research Report
  • 2020 Annual Research Report
  • Research Products

    (28 results)

All 2022 2021 2020

All Journal Article (15 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 15 results,  Open Access: 8 results) Presentation (13 results) (of which Invited: 12 results)

  • [Journal Article] Association of Sleep-disordered Breathing and Blood Pressure with Albuminuria: The Nagahama Study2022

    • Author(s)
      Murase Kimihiko、Matsumoto Takeshi、Tabara Yasuharu、Ohler Adrienne、et al.
    • Journal Title

      Annals of the American Thoracic Society

      Volume: 19 Issue: 3 Pages: 451-461

    • DOI

      10.1513/annalsats.202105-528oc

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Differences between subjective and objective sleep duration according to actual sleep duration and sleep-disordered breathing: the Nagahama Study2022

    • Author(s)
      Takahashi Naomi, Matsumoto Takeshi, Nakatsuka Yoshinari, Murase Kimihiko, Tabara Yasuharu, et al.
    • Journal Title

      Journal of Clinical Sleep Medicine

      Volume: 18 Issue: 3 Pages: 851-859

    • DOI

      10.5664/jcsm.9732

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Multimodal Telemonitoring for Weight Reduction in Patients With Sleep Apnea2022

    • Author(s)
      Murase Kimihiko、Gozal David、Kasai Takatoshi、et al.
    • Journal Title

      Chest

      Volume: 162 Issue: 6 Pages: 1373-1383

    • DOI

      10.1016/j.chest.2022.07.032

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Development of airflow limitation, dyspnoea, and both in the general population: the Nagahama study2022

    • Author(s)
      Kogo Mariko、Sato Susumu、Muro Shigeo、Matsumoto Hisako、Nomura Natsuko、Tashima Noriyuki、Oguma Tsuyoshi、Sunadome Hironobu、Nagasaki Tadao、Murase Kimihiko、Kawaguchi Takahisa、Tabara Yasuharu、Matsuda Fumihiko、Chin Kazuo、Hirai Toyohiro
    • Journal Title

      Scientific Reports

      Volume: 12 Issue: 1 Pages: 20060-20060

    • DOI

      10.1038/s41598-022-24657-w

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Sleep disordered breathing and haemoglobin A1c levels within or over normal range and ageing or sex differences: the Nagahama study2022

    • Author(s)
      Matsumoto Takeshi、Murase Kimihiko、Tabara Yasuharu et al
    • Journal Title

      Journal of Sleep Research

      Volume: 32 Issue: 3

    • DOI

      10.1111/jsr.13795

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Impacts of lipid-related metabolites, adiposity, and genetic background on blood eosinophil counts: the Nagahama study2021

    • Author(s)
      Nishi Kenta、Matsumoto Hisako、Tashima Noriyuki、Terada Satoru、Nomura Natsuko、Kogo Mariko、Morimoto Chie、Sunadome Hironobu、Nagasaki Tadao、Oguma Tsuyoshi、Nakatsuka Yoshinari、Murase Kimihiko、Kawaguchi Takahisa、Tabara Yasuharu、Sonomura Kazuhiro、Matsuda Fumihiko、Chin Kazuo、Hirai Toyohiro
    • Journal Title

      Scientific Reports

      Volume: 11 Issue: 1

    • DOI

      10.1038/s41598-021-94835-9

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Markers of cardiovascular disease risk in sleep-disordered breathing with or without comorbidities: the Nagahama study2021

    • Author(s)
      Nakatsuka Yoshinari、Murase Kimihiko、Matsumoto Takeshi、Tabara Yasuharu、Nakamoto Isuzu、Minami Takuma、Takahashi Naomi、Takeyama Hirofumi、Kanai Osamu、Hamada Satoshi、Tanizawa Kiminobu、Handa Tomohiro、Wakamura Tomoko、Komenami Naoko、Morita Satoshi、Nakayama Takeo、Hirai Toyohiro、Matsuda Fumihiko、Chin Kazuo
    • Journal Title

      Journal of Clinical Sleep Medicine

      Volume: 17 Issue: 12 Pages: 2467-2475

    • DOI

      10.5664/jcsm.9460

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Gastroesophageal reflux disease is a risk factor for sputum production in the general population: the Nagahama study2021

    • Author(s)
      Morimoto Chie、Matsumoto Hisako、Nagasaki Tadao、Kanemitsu Yoshihiro、Ishiyama Yumi、Sunadome Hironobu、Oguma Tsuyoshi、Ito Isao、Murase Kimihiko、Kawaguchi Takahisa、Tabara Yasuharu、Niimi Akio、Muro Shigeo、Matsuda Fumihiko、Chin Kazuo、Hirai Toyohiro
    • Journal Title

      Respiratory Research

      Volume: 22 Issue: 1 Pages: 6-6

    • DOI

      10.1186/s12931-020-01601-y

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Similar distribution of peripheral blood eosinophil counts in European and East Asian populations from investigations of large-scale general population studies: the Nagahama Study2021

    • Author(s)
      Sunadome Hironobu、Sato Susumu、Matsumoto Hisako、Murase Kimihiko、Kawaguchi Takahisa、Tabara Yasuharu、Chin Kazuo、Matsuda Fumihiko、Hirai Toyohiro
    • Journal Title

      European Respiratory Journal

      Volume: 57 Issue: 1 Pages: 2004101-2004101

    • DOI

      10.1183/13993003.04101-2020

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Night-time frequency of urination as a manifestation of sleep-disordered breathing: the Nagahama study2021

    • Author(s)
      Hamada Satoshi、Tabara Yasuharu、Murase Kimihiko、et al.
    • Journal Title

      Sleep Medicine

      Volume: 77 Pages: 288-294

    • DOI

      10.1016/j.sleep.2020.09.007

    • Related Report
      2021 Annual Research Report 2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Impact of sleep-disordered breathing on glucose metabolism among individuals with a family history of diabetes: the Nagahama study2021

    • Author(s)
      Minami T、Matsumoto T、Tabara Y、Gozal D、Smith D、Murase K、Tanizawa K、Takahashi N、Nakatsuka Y、Hamada S、Handa T、Takeyama H、Oga T、Nakamoto I、Wakamura T、Komenami N、Setoh K、Tsutsumi T、Kawaguchi T、Kamatani Y、Takahashi Y、Morita S、Nakayama T、Hirai T、Matsuda F、Chin K、on behalf of the Nagahama Study Group
    • Journal Title

      Journal of Clinical Sleep Medicine

      Volume: 17 Issue: 2 Pages: 129-140

    • DOI

      10.5664/jcsm.8796

    • Related Report
      2021 Annual Research Report 2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Prospective associations of sleep apnea, periodic limb movements, and plasma fibrinogen level2020

    • Author(s)
      Murase Kimihiko、Azuma Masanori、Tachikawa Ryo、Minami Takuma、Matsumoto Takeshi、Hamada Satoshi、Nakatsuka Yoshinari、Takahashi Naomi、Takeyama Hirofumi、Tanizawa Kiminobu、Oga Toru、Handa Tomohiro、Hirai Toyohiro、Chin Kazuo
    • Journal Title

      Sleep and Breathing

      Volume: Online ahead of print Issue: 2 Pages: 617-625

    • DOI

      10.1007/s11325-020-02147-5

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sleep disordered breathing and metabolic comorbidities across sex and menopausal status in East Asians: the Nagahama Study2020

    • Author(s)
      Matsumoto Takeshi、Murase Kimihiko、Tabara Yasuharu、et al.
    • Journal Title

      European Respiratory Journal

      Volume: 56 Issue: 2 Pages: 1902251-1902251

    • DOI

      10.1183/13993003.02251-2019

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Home device-monitored sleep blood pressure reflects large artery stiffness: the Nagahama study2020

    • Author(s)
      Tabara Yasuharu、Matsumoto Takeshi、Murase Kimihiko、Setoh Kazuya、Kawaguchi Takahisa、Kosugi Shinji、Nakayama Takeo、Hirai Toyohiro、Wakamura Tomoko、Chin Kazuo、Matsuda Fumihiko
    • Journal Title

      Journal of Hypertension

      Volume: 38 Issue: 12 Pages: 2459-2464

    • DOI

      10.1097/hjh.0000000000002576

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Correlates of autonomic nervous system function in a general population with special reference to HbA1c: The Nagahama study.2020

    • Author(s)
      Takahashi N, Takahashi Y, Tabara Y, Matsumoto T, Kawaguchi T, Kuriyama A, Ueshima K, Matsuda F, Chin K, Nakayama T; Nagahama Study Group
    • Journal Title

      Diabetes Res Clin Pract

      Volume: 163 Pages: 108126-108126

    • DOI

      10.1016/j.diabres.2020.108126

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 学際的な睡眠学と呼吸器内科、そして呼吸管理、会長講演2022

    • Author(s)
      陳 和夫
    • Organizer
      日本睡眠学会第47回定期学術集会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 睡眠呼吸障害と睡眠休養感,シンポジウム22,睡眠休養感と関連する睡眠障害、環境・行動要因2022

    • Author(s)
      陳 和夫
    • Organizer
      日本睡眠学会第47回定期学術集会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] オンライン診療の現状と課題,シンポジウム9, CPAPと在宅酸素の遠隔モニタリング2022

    • Author(s)
      陳 和夫
    • Organizer
      第62回日本呼吸器学会学術講演会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 睡眠時無呼吸を含む睡眠関連呼吸障害の睡眠検診の有用性に関して,ワークショップ2,経済損失を考慮した睡眠健康診査の必要性2022

    • Author(s)
      陳 和夫
    • Organizer
      日本睡眠学会第46回定期学術集会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 呼吸不全に対するASV,ワークショップ6,Adaptive servo ventilation(ASV)って知っていますか?~ASVの歴史と現状・今後の可能性について~2022

    • Author(s)
      陳 和夫
    • Organizer
      日本睡眠学会第47回定期学術集会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] OSAに対する新規薬物療法の可能性2021

    • Author(s)
      陳 和夫
    • Organizer
      第61回日本呼吸器学会学術講演会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 呼吸機能の評価と解釈2021

    • Author(s)
      陳 和夫
    • Organizer
      第61回日本呼吸器学会学術講演会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 本邦における持続陽圧呼吸療法患者の遠隔モニタリング2021

    • Author(s)
      陳 和夫
    • Organizer
      日本睡眠学会第46回定期学術集会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 肺胞低換気を合併した睡眠呼吸障害を有する心不全に対する治療2021

    • Author(s)
      陳 和夫
    • Organizer
      日本睡眠学会第46回定期学術集会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 睡眠呼吸障害とHbA1c値及び糖尿病治療の有無との関連:ながはまスタディ2021

    • Author(s)
      松本健、村瀬公彦、田原康玄、南卓馬、谷澤公伸、若村智子、平井豊博、松田文彦、陳和夫
    • Organizer
      第61回日本呼吸器学会学術講演会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 呼吸機能の評価と解釈2021

    • Author(s)
      陳和夫
    • Organizer
      第61回日本呼吸器学会学術講演会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] OSAに対する新規薬物療法の可能性2021

    • Author(s)
      陳和夫
    • Organizer
      第61回日本呼吸器学会学術講演会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 研究と臨床と教育:今一歩2021

    • Author(s)
      陳和夫
    • Organizer
      第30回日本呼吸ケア・リハビリテーション学会学術集会
    • Related Report
      2020 Annual Research Report
    • Invited

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Published: 2020-04-28   Modified: 2024-01-30  

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