Cellular senescence of renal "subpopulations" influences renal aging and injury responsiveness
| Project/Area Number |
20H03697
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Review Section |
Basic Section 53040:Nephrology-related
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
築山 智之 滋賀医科大学, 動物生命科学研究センター, 特任准教授 (60612132)
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| Project Period (FY) |
2020-04-01 – 2023-03-31
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| Project Status |
Completed (Fiscal Year 2022)
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| Budget Amount *help |
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2022: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2021: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2020: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
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| Keywords | 慢性腎臓病 / 細胞老化 / 三次リンパ組織 / 亜集団 / シングルセル解析 / 老化関連T細胞 / エリスロポエチン / 線維芽細胞 / シングルセル / 急性腎障害 |
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| Outline of Research at the Start |
本課題ではシングルセル解析を用いて腎臓構成細胞の亜集団を同定し、その機能を解明する。さらに、任意の細胞に任意の時点で細胞老化を誘導できる細胞老化誘導マウスを用いて、腎臓の各種構成細胞に細胞老化を誘導し、前述の亜集団の挙動や機能がどのように変化するかを検討するとともに、細胞老化の誘導が、周辺の細胞や臓器機能、障害応答性、さらには遠隔臓器にどのように影響するのかを解明する。
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| Outline of Final Research Achievements |
The principal investigator found that subpopulations of renal parenchymal cells within and outside tertiary lymphoid tissues in the kidney promote inflammation and contribute to prolonged inflammation and maladaptive repair via their interactions with the tertiary lymphoid tissues, and that the interaction of CD153-CD30 interaction between senescence-associated T cells and senescence-associated B cells contributes to the maturation of tertiary lymphoid tissues and progression of kidney dysfunction. We also elucidated the behavior of erythropoietin-producing subpopulation within fibroblasts.
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| Academic Significance and Societal Importance of the Research Achievements |
慢性腎臓病は世界人口の約10%が罹患し、様々な合併症を伴う重大な健康障害である。特に高齢者の慢性腎臓病患者は増加傾向であり、社会的、医療経済的な健康問題となっている。腎三次リンパ組織の形成はその一因と考えられ、それらを標的とした治療法の開発は重要である。本研究課題により、その病態を明らかにすることで、治療開発に貢献できるとともに、慢性腎臓病患者の減少、生活の質の改善、医療費の軽減に寄与できる可能性がある。
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Report
(4 results)
Research Products
(51 results)
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[Journal Article] Urinary <scp>FABP1</scp> is a biomarker for impaired proximal tubular protein reabsorption and is synergistically enhanced by concurrent liver injury2021
Author(s)
Kawakami Ryo, Matsui Miki, Konno Ayumu, Kaneko Ryosuke, Shrestha Suman, Sunaga Hiroaki, Hanaoka Hirofumi, Goto Sawako, Hosojima Michihiro, Kabasawa Hideyuki, Obokata Masaru, Koitabashi Norimichi, Matsui Hiroki, Sasaki Tsutomu, Saito Akihiko, Yanagita Motoko, Hirai Hirokazu, Kurabayashi Masahiko, Iso Tatsuya
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Journal Title
The Journal of Pathology
Volume: 255
Issue: 4
Pages: 362-373
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Cilastatin Ameliorates Rhabdomyolysis-induced AKI in Mice2021
Author(s)
Matsushita Katsuyuki、Mori Kiyoshi、Saritas Turgay、Eiwaz Mahaba B.、Funahashi Yoshio、Nickerson Megan N.、Hebert Jessica F.、Munhall Adam C.、McCormick James A.、Yanagita Motoko、Hutchens Michael P.
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Journal Title
Journal of the American Society of Nephrology
Volume: 32
Issue: 10
Pages: 2579-2594
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Eicosapentaenoic acid attenuates renal lipotoxicity by restoring autophagic flux.2020
Author(s)
Yamamoto T, Takabatake Y*, Minami S, Takahashi A, Sakai S, Fujimura R, Takahashi A, Namba-Hamano T, Matsuda J, Kimura T, Matsui I, Kaimori J, Takeda H, Takahashi M, Izumi Y, Bamba T, Matsusaka T, Niimura F, Yanagita M, Isaka Y.
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Journal Title
Autophagy
Volume: 28
Issue: 7
Pages: 1-14
DOI
Related Report
Peer Reviewed
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