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Molecular signatures in pre-RA patients by multi-omics analysis

Research Project

Project/Area Number 20H03720
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 54020:Connective tissue disease and allergy-related
Research InstitutionKeio University

Principal Investigator

TAKEUCHI Tsutomu  慶應義塾大学, 医学部(信濃町), 特任教授 (50179610)

Co-Investigator(Kenkyū-buntansha) 竹下 勝  慶應義塾大学, 医学部(信濃町), 講師 (10571135)
近藤 泰  慶應義塾大学, 医学部(信濃町), 助教 (50626380)
金子 祐子  慶應義塾大学, 医学部(信濃町), 教授 (60317112)
鈴木 勝也  慶應義塾大学, 医学部(信濃町), 准教授 (70306695)
Project Period (FY) 2020-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2022: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2021: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2020: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
Keywords関節リウマチ / シングルセル解析 / 自己抗体 / 間質性肺炎 / 自己免疫疾患 / リンパ球 / 抗原特異性 / 抗シトルリン化タンパク質抗体 / 抗翻訳後修飾蛋白抗体 / 肺胞洗浄液 / リウマチ因子 / 寛解、分子病態、網羅的解析 / 診断前継時コホート / 残存分子シグネチャー
Outline of Research at the Start

関節リウマチの治療は分子標的薬によって劇的な進歩を遂げたが、治療目標である臨床的寛解の100%達成は未だに困難である。また、仮に寛解を達成したとしてもその継続は難しく、治療薬の中止により再燃が避けられない。RA診断のゴールデンスタンダードとなっている2010年ACR/EULAR分類基準を満足する確立されたRA)の前の状態、すなわちプレRAで治療介入すれば関節炎の範囲は限定的であるため、これらの課題は克服できる可能性がある。本研究では、最新のマルチオミックス解析を駆使して、RA発症前のプレRA病態を探りRA発症抑制やRA治療のさらなる向上に直結する研究基盤とマルチオミックス情報を構築、獲得したい。

Outline of Final Research Achievements

In this study, in order to further improve the current treatment of rheumatoid arthritis and to clarify the pathogenesis leading to established RA, we performed a multi-omics analysis using synovial joint and lung lesion samples from early onset or pre-RA patients, combining the latest comprehensive analysis techniques. In particular, we were able to show that T cell-B cell associations and disease-specific autoantibody production precede lung lesions, and that suppression of these immune responses may lead to improved therapeutic outcomes.

Academic Significance and Societal Importance of the Research Achievements

早期・超早期の関節リウマチの病変局所の免疫応答の詳細解析として、一連の解析手法を確立し、疾患の病態プロセスに関わる細胞群を同定することができた。本研究で得られた情報は今後の治療戦略を考える上で重要な手掛かりとなると考えられた。さらに本研究で明らかに出来た病変部位での免疫応答は広く全身性自己免疫疾患に共通するものである可能性が示唆され、他の疾患の病態研究に応用可能と考えられた。

Report

(4 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Annual Research Report
  • 2020 Annual Research Report
  • Research Products

    (60 results)

All 2023 2022 2021 2020

All Journal Article (57 results) (of which Int'l Joint Research: 23 results,  Peer Reviewed: 55 results,  Open Access: 57 results) Presentation (3 results)

  • [Journal Article] Efficacy and pharmacokinetics of ozoralizumab, an anti-TNFα NANOBODY compound, in patients with rheumatoid arthritis: 52-week results from the OHZORA and NATSUZORA trials2023

    • Author(s)
      Takeuchi Tsutomu、Chino Yukihiro、Kawanishi Masafumi、Nakanishi Megumi、Watase Hirotaka、Mano Yoko、Sato Yuri、Uchida Saeko、Tanaka Yoshiya
    • Journal Title

      Arthritis Research and Therapy

      Volume: 25 Issue: 1

    • DOI

      10.1186/s13075-023-03036-4

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Reduced versus maximum tolerated methotrexate dose concomitant with adalimumab in patients with rheumatoid arthritis (MIRACLE): a randomised, open-label, non-inferiority trial2023

    • Author(s)
      Tamai Hiroya、Tsutomu Takeuchi et al.
    • Journal Title

      The Lancet Rheumatology

      Volume: 5 Issue: 4 Pages: e215-e224

    • DOI

      10.1016/s2665-9913(23)00070-x

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Successful treatment of IgG4-related disease with tocilizumab monotherapy2023

    • Author(s)
      Akiyama Mitsuhiro、Hayashi Yutaro、Suzuki Koji、Takeuchi Tsutomu、Kaneko Yuko
    • Journal Title

      Autoimmunity Reviews

      Volume: 22 Issue: 4 Pages: 103296-103296

    • DOI

      10.1016/j.autrev.2023.103296

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Longitudinal monitoring of circulating immune cell phenotypes in anti-neutrophil cytoplasmic antibody-associated vasculitis2023

    • Author(s)
      Matsumoto Kotaro、Suzuki Katsuya、Yasuoka Hidekata、Hirahashi Junichi、Yoshida Hiroto、Magi Mayu、Noguchi-Sasaki Mariko、Kaneko Yuko、Takeuchi Tsutomu
    • Journal Title

      Autoimmunity Reviews

      Volume: 22 Issue: 3 Pages: 103271-103271

    • DOI

      10.1016/j.autrev.2023.103271

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Distinct gene signatures of monocytes and B cells in patients with giant cell arteritis: a longitudinal transcriptome analysis2023

    • Author(s)
      Kotaro Matsumoto, Katsuya Suzuki, Hiroto Yoshida, Mayu Magi, Yoshihiro Matsumoto, Mariko Noguchi-Sasaki, Keiko Yoshimoto, Tsutomu Takeuchi, Yuko Kaneko
    • Journal Title

      Arthritis Res Ther.

      Volume: 25 Issue: 1 Pages: 1-1

    • DOI

      10.1186/s13075-022-02982-9

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Nation-wide cohort study of remission induction therapy using rituximab in Japanese patients with antineutrophil cytoplasmic antibody associated vasculitis: Effectiveness and safety in the first 6 months2022

    • Author(s)
      Nagasaka Kenji、Amano Koichi、Dobashi Hiroaki、Nagafuchi Hiroko、Sada Ken-Ei、Komagata Yoshinori、Yamamura Masahiro、Kato Masaru、Endo Tomomi、Nakaya Izaya、Takeuchi Tsutomu、et al.
    • Journal Title

      Modern Rheumatology

      Volume: ー Issue: 6 Pages: 1117-1124

    • DOI

      10.1093/mr/roac150

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Differences in the strength of inhibition of interleukin-6 signalling by subcutaneous sarilumab and tocilizumab in rheumatoid arthritis patients2022

    • Author(s)
      Saito Shuntaro、Suzuki Katsuya、Yoshimoto Keiko、Kondo Yasushi、Kikuchi Jun、Hanaoka Hironari、Kaneko Yuko、Takeuchi Tsutomu
    • Journal Title

      Clinical and Experimental Rheumatology

      Volume: ー Pages: 1451-1455

    • DOI

      10.55563/clinexprheumatol/k0ctlf

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Thymus variants on imaging of patients with primary Sjogren’s syndrome and polymyositis/dermatomyositis: clinical and immunological significance2022

    • Author(s)
      Murata Okinori、Suzuki Katsuya、Takeuchi Tsutomu
    • Journal Title

      Immunological Medicine

      Volume: 46 Issue: 1 Pages: 25-31

    • DOI

      10.1080/25785826.2022.2129371

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Relative Impact of Pain and Disease Activity on Improvements in Fatigue2022

    • Author(s)
      Fautrel Bruno、Wu Jianmin、Wang Duzhe、Haladyj Ewa、van de Laar Mart A. F. J.、Takeuchi Tsutomu
    • Journal Title

      JCR: Journal of Clinical Rheumatology

      Volume: 29 Pages: 139-144

    • DOI

      10.1097/rhu.0000000000001924

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Correction: Cytokines and cytokine receptors as targets of immune-mediated inflammatory diseases RA as a role model2022

    • Author(s)
      Takeuchi Tsutomu
    • Journal Title

      Inflammation and Regeneration

      Volume: 42 Issue: 1

    • DOI

      10.1186/s41232-022-00250-6

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Safety of synthetic and biological DMARDs: a systematic literature review informing the 2022 update of the EULAR recommendations for the management of rheumatoid arthritis2022

    • Author(s)
      Sepriano Alexandre、Kerschbaumer Andreas、Bergstra Sytske Anne、Smolen Josef S、van der Heijde D、Caporali Roberto、Edwards Christopher J、Verschueren Patrick、de Souza Savia、Pope Janet、Takeuchi Tsutomu、Hyrich Kimme、Winthrop Kevin L、Aletaha Daniel、Stamm Tanja、Schoones Jan W、Landew Robert B M
    • Journal Title

      Annals of the Rheumatic Diseases

      Volume: 82 Issue: 1 Pages: 107-118

    • DOI

      10.1136/ard-2022-223357

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Efficacy of synthetic and biological DMARDs: a systematic literature review informing the 2022 update of the EULAR recommendations for the management of rheumatoid arthritis2022

    • Author(s)
      Kerschbaumer Andreas、Sepriano Alexandre、Bergstra Sytske Anne、Smolen Josef S、van der Heijde D、Caporali Roberto、Edwards Christopher John、Verschueren Patrick、de Souza Savia、Pope Janet E、Takeuchi Tsutomu、Hyrich Kimme L、Winthrop Kevin L、Aletaha Daniel、Stamm Tanja A、Schoones Jan W、Landew Robert B M
    • Journal Title

      Annals of the Rheumatic Diseases

      Volume: 82 Issue: 1 Pages: 95-106

    • DOI

      10.1136/ard-2022-223365

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Efficacy, duration of use and safety of glucocorticoids: a systematic literature review informing the 2022 update of the EULAR recommendations for the management of rheumatoid arthritis2022

    • Author(s)
      Bergstra Sytske Anne、Sepriano Alexandre、Kerschbaumer Andreas、van der Heijde D、Caporali Roberto、Edwards Christopher John、Verschueren Patrick、de Souza Savia、Pope Janet E、Takeuchi Tsutomu、Hyrich Kimme L、Winthrop Kevin L、Aletaha Daniel、Stamm Tanja A、Schoones Jan W、Smolen Josef S、Landew Robert B M
    • Journal Title

      Annals of the Rheumatic Diseases

      Volume: 82 Issue: 1 Pages: 81-94

    • DOI

      10.1136/ard-2022-223358

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2022 update2022

    • Author(s)
      Smolen Josef S、Landew Robert B M、、Tsutomu Takeuchi, et al.
    • Journal Title

      Annals of the Rheumatic Diseases

      Volume: 82 Issue: 1 Pages: 3-18

    • DOI

      10.1136/ard-2022-223356

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Associations of improvement in laboratory tests with clinical outcomes in patients with active systemic lupus erythematosus: a multinational longitudinal cohort study2022

    • Author(s)
      Connelly Kathryn、Kandane-Rathnayake Rangi、、Tsutomu Takeuchi, et al.
    • Journal Title

      The Lancet Rheumatology

      Volume: 4 Issue: 12 Pages: e831-e841

    • DOI

      10.1016/s2665-9913(22)00307-1

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Benefit of Filgotinib, a JAK1 Preferential Inhibitor, in Rheumatoid Arthritis Patients with Previous Rapid Radiographic Progression: Post Hoc Analysis of Two Trials2022

    • Author(s)
      Tanaka Yoshiya、Atsumi Tatsuya、Aletaha Daniel、Bartok Beatrix、Pechonkina Alena、Han Ling、Emoto Kahaku、Kano Shungo、Rajendran Vijay、Takeuchi Tsutomu
    • Journal Title

      Rheumatology and Therapy

      Volume: NA

    • DOI

      10.1007/s40744-022-00503-3

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Lupus low disease activity state and remission and risk of mortality in patients with systemic lupus erythematosus: a prospective, multinational, longitudinal cohort study2022

    • Author(s)
      Kandane-Rathnayake Rangi、Golder Vera、Tsutomu Takeuchi, et al.
    • Journal Title

      The Lancet Rheumatology

      Volume: 4 Issue: 12 Pages: e822-e830

    • DOI

      10.1016/s2665-9913(22)00304-6

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Efficacy and safety of anti-TNF multivalent NANOBODY compound ‘ozoralizumab’ without methotrexate co-administration in patients with active rheumatoid arthritis: A 52-week result of phase III, randomised, open-label trial (NATSUZORA trial)2022

    • Author(s)
      Tanaka Yoshiya、Kawanishi Masafumi、Nakanishi Megumi、Yamasaki Hironori、Takeuchi Tsutomu
    • Journal Title

      Modern Rheumatology

      Volume: ー Issue: 5 Pages: 875-882

    • DOI

      10.1093/mr/roac126

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Efficacy and safety of the anti-TNF multivalent NANOBODY compound ozoralizumab in patients with rheumatoid arthritis and an inadequate response to methotrexate: A 52-week result of a Phase II/III study (OHZORA trial)2022

    • Author(s)
      Tanaka Yoshiya、Kawanishi Masafumi、Nakanishi Megumi、Yamasaki Hironori、Takeuchi Tsutomu
    • Journal Title

      Modern Rheumatology

      Volume: ー Issue: 5 Pages: 883-890

    • DOI

      10.1093/mr/roac119

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association between the patterns of large-vessel lesions and treatment outcomes in patients with large-vessel giant cell arteritis2022

    • Author(s)
      Sugihara Takahiko、Uchida Haruhito A、Yoshifuji Hajime、Maejima Yasuhiro、Naniwa Taio、Katsumata Yasuhiro、Okazaki Takahiro、Ishizaki Jun、Murakawa Yohko、Ogawa Noriyoshi、Dobashi Hiroaki、Horita Tetsuya、Tanaka Yoshiya、Furuta Shunsuke、Takeuchi Tsutomu、Komagata Yoshinori、Nakaoka Yoshikazu、Harigai Masayoshi
    • Journal Title

      Modern Rheumatology

      Volume: ー Issue: 6 Pages: 1145-1153

    • DOI

      10.1093/mr/roac122

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Serum cytokines and bone metabolic markers in patients with rheumatoid arthritis treated with biological disease modifying anti-rheumatic drugs2022

    • Author(s)
      Tamai Hiroya、Nishina Naoshi、Kikuchi Jun、Izumi Keisuke、Otomo Kotaro、Yoshimoto Keiko、Yamaoka Kunihiro、Takeuchi Tsutomu、Kaneko Yuko
    • Journal Title

      Clinical Rheumatology

      Volume: 42 Issue: 3 Pages: 721-730

    • DOI

      10.1007/s10067-022-06390-x

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association of Modified Systemic Lupus Erythematosus Responder Index Attainment With <scp>Long‐Term</scp> Clinical Outcomes: A <scp>Five‐Year</scp> Prospective Study2022

    • Author(s)
      Connelly Kathryn、Kandane‐Rathnayake Rangi、Tsutomu Takeuchi, et al.
    • Journal Title

      Arthritis and Rheumatology

      Volume: 75 Issue: 3 Pages: 401-410

    • DOI

      10.1002/art.42350

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Efficacy and tolerability of subcutaneously administered methotrexate including dose escalation in long-term treatment of rheumatoid arthritis in a Japanese population2022

    • Author(s)
      Tanaka Yoshiya、Okuda Kosuke、Takeuchi Yohei、Katayama Kou、Haji Yoichiro、Yamanishi Yuji、Tribanek Michael、Guimbal-Schmolck Cecile、Takeuchi Tsutomu
    • Journal Title

      Modern Rheumatology

      Volume: ー Issue: 4 Pages: 680-689

    • DOI

      10.1093/mr/roac103

    • Related Report
      2022 Annual Research Report
    • Open Access
  • [Journal Article] A systematic literature review informing the consensus statement on efficacy and safety of pharmacological treatment with interleukin-6 pathway inhibition with biological DMARDs in immune-mediated inflammatory diseases2022

    • Author(s)
      Kastrati Kastriot、Aletaha Daniel、Burmester Gerd R、Chwala Eva、Dejaco Christian、Dougados Maxime、McInnes Iain B、Ravelli Angelo、Sattar Naveed、Stamm Tanja A、Takeuchi Tsutomu、Trauner Michael、van der Heijde D、Voshaar Marieke J H、Winthrop Kevin、Smolen Josef S、Kerschbaumer Andreas
    • Journal Title

      RMD Open

      Volume: 8 Issue: 2 Pages: e002359-e002359

    • DOI

      10.1136/rmdopen-2022-002359

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Consensus statement on blocking interleukin-6 receptor and interleukin-6 in inflammatory conditions: an update2022

    • Author(s)
      Aletaha Daniel、Kerschbaumer Andreas、Tsutomu Takeuchi, et al.
    • Journal Title

      Annals of the Rheumatic Diseases

      Volume: ー Issue: 6 Pages: 773-787

    • DOI

      10.1136/ard-2022-222784

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Safety and effectiveness of baricitinib for rheumatoid arthritis in Japanese clinical practice: 24-week results of all-case post-marketing surveillance2022

    • Author(s)
      Takagi Michiaki、Atsumi Tatsuya、Matsuno Hiroaki、Tamura Naoto、Fujii Takao、Okamoto Nami、Takahashi Nobunori、Nakajima Atsuo、Nakajima Ayako、Tsujimoto Naoto、Nishikawa Atsushi、Ishii Taeko、Takeuchi Tsutomu、Kuwana Masataka
    • Journal Title

      Modern Rheumatology

      Volume: ー Issue: 4 Pages: 647-656

    • DOI

      10.1093/mr/roac089

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Safety and efficacy of filgotinib for Japanese patients with RA and inadequate response to MTX: FINCH 1 52-week results and FINCH 4 48-week results2022

    • Author(s)
      Tanaka Yoshiya、Matsubara Tsukasa、Tsutomu Takeuchi, et al.
    • Journal Title

      Modern Rheumatology

      Volume: ー Issue: 4 Pages: 668-679

    • DOI

      10.1093/mr/roac084

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Long-term safety and efficacy of filgotinib treatment for rheumatoid arthritis in Japanese patients naive to MTX treatment (FINCH 3)2022

    • Author(s)
      Atsumi Tatsuya、Tanaka Yoshiya、Matsubara Tsukasa、Amano Koichi、Ishiguro Naoki、Sugiyama Eiji、Yamaoka Kunihiro、Westhovens Ren、Ching Daniel W T、Messina Osvaldo Daniel、Burmester Gerd R、Genovese Mark、Bartok Beatrix、Pechonkina Alena、Kondo Akira、Yin Zhaoyu、Gong Qi、Tasset Chantal、Takeuchi Tsutomu
    • Journal Title

      Modern Rheumatology

      Volume: ー Issue: 4 Pages: 657-667

    • DOI

      10.1093/mr/roac083

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Longitudinal monitoring of circulating immune cell phenotypes in large vessel vasculitis2022

    • Author(s)
      Matsumoto Kotaro、Suzuki Katsuya、Yoshida Hiroto、Magi Mayu、Kaneko Yuko、Takeuchi Tsutomu
    • Journal Title

      Autoimmunity Reviews

      Volume: 21 Issue: 10 Pages: 103160-103160

    • DOI

      10.1016/j.autrev.2022.103160

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Abatacept ameliorates both glandular and extraglandular involvements in patients with Sjogren’s syndrome associated with rheumatoid arthritis: Findings from an open-label, multicentre, 1-year, prospective study: The ROSE (Rheumatoid Arthritis with Orencia Trial Toward Sj?gren’s Syndrome Endocrinopathy) and ROSE II trials2022

    • Author(s)
      Tsuboi H, Toko H, Honda F, Abe S, Takahashi H, Yagishita M, Hagiwara S, Ohyama A, Kondo Y, Nakano K, Tanaka Y, Shimizu T, Nakamura H, Kawakami A, Fujieda Y, Atsumi T, Suzuki Y, Kawano M, Nishina N, Kaneko Y, Takeuchi T, Kobayashi H, Takei M, Ogasawara M, Tamura N, Takasaki Y, Yokota K, Akiyama Y, Mimura T, et al.
    • Journal Title

      Modern Rheumatology

      Volume: 33 Issue: 1 Pages: 160-168

    • DOI

      10.1093/mr/roac011

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Disease-specific expansion of CD29+IL-17RA+ T effector cells possessing multiple signalling pathways in spondyloarthritis2022

    • Author(s)
      Akiyama Mitsuhiro、Yoshimoto Keiko、Ishigaki Sho、Suzuki Katsuya、Takeuchi Tsutomu、Kaneko Yuko
    • Journal Title

      Rheumatology

      Volume: 62 Issue: 3 Pages: 1296-1305

    • DOI

      10.1093/rheumatology/keac391

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Role of interferons (IFNs) in the differentiation of T peripheral helper (Tph) cells: : 1. Type I IFNs promote the differentiation of interleukin-21-producing Tph-like cells2022

    • Author(s)
      Shuhei Tanemura, Hideto Tsujimoto, Noriyasu Seki, Shinji Kojima, Fumihiko Miyoshi, Kunio Sugahara, Keiko Yoshimoto, Katsuya Suzuki, Yuko Kaneko, Kenji Chiba, Tsutomu Takeuchi
    • Journal Title

      Int Immunol

      Volume: 34(10) Issue: 10 Pages: 519-532

    • DOI

      10.1093/intimm/dxac026

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Biological insights into systemic lupus erythematosus through an immune cell-specific transcriptome-wide association study2022

    • Author(s)
      Yin Xianyong、Kim Kwangwoo、Tsutomu Takeuchi, et al.
    • Journal Title

      Annals of the Rheumatic Diseases

      Volume: 81 Issue: 9 Pages: 1273-1280

    • DOI

      10.1136/annrheumdis-2022-222345

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] T follicular helper cells mediate local production of allergen-specific IgE and IgG42022

    • Author(s)
      Akiyama Mitsuhiro、Kaneko Yuko、Takeuchi Tsutomu
    • Journal Title

      Journal of Allergy and Clinical Immunology

      Volume: 150 Issue: 5 Pages: 1045-1047

    • DOI

      10.1016/j.jaci.2022.05.003

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The efficacy and safety of anifrolumab in Japanese patients with systemic lupus erythematosus: TULIP-2 subanalysis2022

    • Author(s)
      Tanaka Yoshiya、Atsumi Tatsuya、Okada Masato、Miyamura Tomoya、Ishii Tomonori、Nishiyama Susumu、Matsumura Ryutaro、Hayashi Nobuya、Abreu Gabriel、Tummala Raj、Morand Eric F、Takeuchi Tsutomu
    • Journal Title

      Modern Rheumatology

      Volume: 33 Issue: 1 Pages: 134-144

    • DOI

      10.1093/mr/roac010

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] <i>Post hoc</i> analysis of clinical characteristics of patients with radiographic progression in a Japanese phase 3 trial of peficitinib and methotrexate treatment (RAJ4)2022

    • Author(s)
      Tanaka Yoshiya、Takeuchi Tsutomu、Kato Daisuke、Kaneko Yuichiro、Fukuda Musashi、Izutsu Hiroyuki、Rokuda Mitsuhiro、van der Heijde D
    • Journal Title

      Modern Rheumatology

      Volume: 33 Issue: 1 Pages: 73-80

    • DOI

      10.1093/mr/roac021

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Integrated safety analysis of filgotinib treatment for rheumatoid arthritis in patients from Japan over a median of 1.5 years2022

    • Author(s)
      Ishiguro Naoki、Tanaka Yoshiya、Matsubara Tsukasa、Atsumi Tatsuya、Amano Koichi、Sugiyama Eiji、Yamaoka Kunihiro、Winthrop Kevin、Kivitz Alan、Burmester Gerd R、Gottenberg Jacques-Eric、Genovese Mark C、Matzkies Franziska、Guo Ying、Jiang Deyuan、Takeuchi Tsutomu
    • Journal Title

      Modern Rheumatology

      Volume: 33 Issue: 1 Pages: 64-72

    • DOI

      10.1093/mr/roac020

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Selection of treatment regimens based on shared decision-making in patients with rheumatoid arthritis on remission in the FREE-J study2022

    • Author(s)
      Tanaka Yoshiya、Yamaguchi Ayako、Miyamoto Toshiaki、Tanimura Kazuhide、Iwai Hideyuki、Kaneko Yuko、Takeuchi Tsutomu、Amano Koichi、Iwamoto Naoki、Kawakami Atsushi、Murakami Miho、Nishimoto Norihiro、Atsumi Tatsuya、Sumida Takayuki、Ohmura Koichiro et al.
    • Journal Title

      Rheumatology

      Volume: - Issue: 11 Pages: 4273-4285

    • DOI

      10.1093/rheumatology/keac075

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Immune evasion and chronological decrease in titer of neutralizing antibody against SARS-CoV-2 and its variants of concerns in COVID-19 patients2022

    • Author(s)
      Takeshita Masaru、Nishina Naoshi、Moriyama Saya、Takahashi Yoshimasa、Ishii Makoto、Saya Hideyuki、Kondo Yasushi、Kaneko Yuko、Suzuki Katsuya、Fukunaga Koichi、Takeuchi Tsutomu
    • Journal Title

      Clinical Immunology

      Volume: 238 Pages: 108999-108999

    • DOI

      10.1016/j.clim.2022.108999

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] ‘Not at target’: prevalence and consequences of inadequate disease control in systemic lupus erythematosus-A multinational observational cohort study2022

    • Author(s)
      Kandane-Rathnayake Rangi、Louthrenoo Worawit、Hoi AlbertaKatsumata Yasuhiro、Harigai MasayoKikuchi Jun、Takeuchi TsutomuFor the Asia-Pacific Lupus Collaboration
    • Journal Title

      Arthritis Research and Therapy

      Volume: 24 Issue: 1

    • DOI

      10.1186/s13075-022-02756-3

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Interleukin-4 as an emerging therapeutic target for IgG4-related disease2022

    • Author(s)
      Akiyama Mitsuhiro、Kaneko Yuko、Takeuchi Tsutomu
    • Journal Title

      Annals of the Rheumatic Diseases

      Volume: 81 Issue: 2 Pages: e28-e28

    • DOI

      10.1136/annrheumdis-2020-216961

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Lupus low disease activity state within 12 months is associated with favourable outcomes in severely active systemic lupus erythematosus2022

    • Author(s)
      Kikuchi Jun、Hanaoka Hironari、Saito Shuntaro、Oshige Tatsuhiro、Hiramoto Kazuoto、Kaneko Yuko、Takeuchi Tsutomu
    • Journal Title

      Rheumatology

      Volume: - Issue: 9 Pages: 3777-3791

    • DOI

      10.1093/rheumatology/keac002

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Should we consider the definition of elderly-onset rheumatoid arthritis in an aging society?2022

    • Author(s)
      Uchiyama S, Takanashi S, Takeno M, Gono T, Takeuchi T, Kaneko Y, and Kuwana M.
    • Journal Title

      Mod Rheum

      Volume: 32 Pages: 322-329

    • Related Report
      2022 Annual Research Report
    • Open Access
  • [Journal Article] Integrated safety analysis of filgotinib in patients with moderately to severely active rheumatoid arthritis receiving treatment over a median of 1.6 years2022

    • Author(s)
      Winthrop Kevin L、Tanaka Yoshiya、Takeuchi Tsutomu、Kivitz Alan、Matzkies Franziska、Genovese Mark C、Jiang Deyuan、Chen Kun、Bartok Beatrix、Jahreis Angelika、Besuyen Robin、Burmester Gerd R、Gottenberg Jacques-Eric
    • Journal Title

      Annals of the Rheumatic Diseases

      Volume: 81 Issue: 2 Pages: 184-192

    • DOI

      10.1136/annrheumdis-2021-221051

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Safety of baricitinib for the treatment of rheumatoid arthritis over a median of 4.6 and up to 9.3 years of treatment: final results from long-term extension study and integrated database2022

    • Author(s)
      Taylor Peter C、Takeuchi Tsutomu、Burmester Gerd R、Durez Patrick、Smolen Josef S、Deberdt Walter、Issa Maher、Terres Jorge Ross、Bello Natalia、Winthrop Kevin L
    • Journal Title

      Annals of the Rheumatic Diseases

      Volume: 81 Issue: 3 Pages: 335-343

    • DOI

      10.1136/annrheumdis-2021-221276

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Long-term safety and effectiveness of mycophenolate mofetil in adults with lupus nephritis: a real-world study in Japan2022

    • Author(s)
      Takeuchi Tsutomu、Hashimoto Hideyuki、Matsumoto Mika
    • Journal Title

      Modern Rheumatology

      Volume: 32 Issue: 4 Pages: 746-754

    • DOI

      10.1093/mr/roab076

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Efficacy and safety of filgotinib alone and in combination with methotrexate in Japanese patients with active rheumatoid arthritis and limited or no prior exposure to methotrexate: Subpopulation analyses of 24-week data of a global phase 3 study (FINCH 3)2022

    • Author(s)
      Atsumi Tatsuya、Tanaka Yoshiya、Matsubara Tsukasa、Amano Koichi、Ishiguro Naoki、Sugiyama Eiji、Yamaoka Kunihiro、Westhovens Ren、Ching Daniel W.T、Messina Osvaldo Daniel、Burmester Gerd R、Bartok Beatrix、Pechonkina Alena、Kondo Akira、Yin Zhaoyu、Guo Ying、Tasset Chantal、Sundy John S、Takeuchi Tsutomu
    • Journal Title

      Modern Rheumatology

      Volume: 32 Issue: 2 Pages: 273-283

    • DOI

      10.1093/mr/roab021

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Real-world safety and efficacy of CT-P13, an infliximab biosimilar, in Japanese rheumatoid arthritis patients naive to or switched from biologics2022

    • Author(s)
      Takeuchi Tsutomu、Nishikawa Kiyohiro、Yamada Fumika、Ohshima Shiro、Inoue Makoto、Yoshioka Yutaka、Yamanaka Hisashi
    • Journal Title

      Modern Rheumatology

      Volume: 32 Issue: 4 Pages: 718-727

    • DOI

      10.1093/mr/roab068

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A pooled analysis of serious infections and herpes zoster-related disease in Asian patients with rheumatoid arthritis treated with peficitinib (ASP015K) over a median of 3 years2022

    • Author(s)
      Tanaka Yoshiya、Takeuchi Tsutomu、Kato Daisuke、Kaneko Yuichiro、Fukuda Musashi、Izutsu Hiroyuki、Rokuda Mitsuhiro
    • Journal Title

      Modern Rheumatology

      Volume: 32 Issue: 4 Pages: 708-717

    • DOI

      10.1093/mr/roab069

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Impact of age on the efficacy and safety of peficitinib (ASP015K) for the treatment of rheumatoid arthritis2022

    • Author(s)
      Tanaka Yoshiya、Takeuchi Tsutomu、Kato Daisuke、Kaneko Yuichiro、Fukuda Musashi、Miyatake Daisuke
    • Journal Title

      Modern Rheumatology

      Volume: 32 Issue: 4 Pages: 696-707

    • DOI

      10.1093/mr/roab058

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Efficacy and safety of filgotinib in combination with methotrexate in Japanese patients with active rheumatoid arthritis who have an inadequate response to methotrexate: Subpopulation analyses of 24-week data of a global phase 3 study (FINCH 1)2022

    • Author(s)
      Tanaka Yoshiya、Matsubara Tsukasa、Atsumi Tatsuya、Amano Koichi、Ishiguro Naoki、Sugiyama Eiji、Yamaoka Kunihiro、Sundy John S、Takeuchi Tsutomu
    • Journal Title

      Modern Rheumatology

      Volume: 32 Issue: 2 Pages: 263-272

    • DOI

      10.1093/mr/roab030

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Efficacy and safety of abatacept in biologic-naive patients with active rheumatoid arthritis by background methotrexate dose: <i>post hoc</i> analysis of a randomized, placebo-controlled, phase 4 study2022

    • Author(s)
      Tanaka Yoshiya、Matsubara Tsukasa、Hashizume Koichi、Amano Norihito、Takeuchi Tsutomu
    • Journal Title

      Modern Rheumatology

      Volume: 32 Issue: 3 Pages: 500-507

    • DOI

      10.1093/mr/roab029

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Rheumatoid arthritis with nontuberculous mycobacterial pulmonary disease: a retrospective, single-centre cohort study2022

    • Author(s)
      Takei Hiroshi、Nishina Naoshi、Namkoong Ho、Suzuki Katsuya、Uwamino Yoshifumi、Hasegawa Naoki、Takeuchi Tsutomu
    • Journal Title

      Modern Rheumatology

      Volume: 32 Issue: 3 Pages: 534-540

    • DOI

      10.1093/mr/roab032

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Novel susceptibility loci for steroid-associated osteonecrosis of the femoral head in systemic lupus erythematosus2021

    • Author(s)
      Suetsugu Hiroyuki、Kim Kwangwoo、Yamamoto Takuaki、Bang So-Young、Sakamoto Yuma、Shin Jung-Min、Sugano Nobuhiko、Kim Ji Soong、Mukai Masaya、Lee Yeon-Kyung、Ohmura Koichiro、Park Dae Jin、Takahashi Daisuke、Ahn Ga-Young、Karino Kohei、Kwon Young-Chang、Miyamura Tomoya、Kim Jihye、Nakamura Junichi、et al
    • Journal Title

      Human Molecular Genetics

      Volume: 31 Issue: 7 Pages: 1082-1095

    • DOI

      10.1093/hmg/ddab306

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Immunoglobulin G4?related disease and idiopathic multicentric Castleman’s disease: confusable immune-mediated disorders2021

    • Author(s)
      Sasaki Takanori、Akiyama Mitsuhiro、Kaneko Yuko、Takeuchi Tsutomu
    • Journal Title

      Rheumatology

      Volume: 61 Issue: 2 Pages: 490-501

    • DOI

      10.1093/rheumatology/keab634

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Antigen-driven autoantibody production in lungs of interstitial lung disease with autoimmune disease2021

    • Author(s)
      Takeshita Masaru、Suzuki Katsuya、Nakazawa Maho、Kamata Hirofumi、Ishii Makoto、Oyamada Yoshitaka、Oshima Hisaji、Takeuchi Tsutomu
    • Journal Title

      Journal of Autoimmunity

      Volume: 121 Pages: 102661-102661

    • DOI

      10.1016/j.jaut.2021.102661

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Distinct Expression of Coinhibitory Molecules on Alveolar T Cells in Patients With Rheumatoid Arthritis Associated and Idiopathic Inflammatory Myopathy Associated Interstitial Lung Disease2021

    • Author(s)
      Nakazawa Maho、Suzuki Katsuya、Takeshita Masaru、Inamo Jun、Kamata Hirofumi、Ishii Makoto、Oyamada Yoshitaka、Oshima Hisaji、Takeuchi Tsutomu
    • Journal Title

      Arthritis & Rheumatology

      Volume: 73 Issue: 4 Pages: 576-586

    • DOI

      10.1002/art.41554

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Transcriptome analysis of alveolar macrophages identifies involvement of PD-1/PD-Ls in pathogenesis of rheumatoid arthritis-associated interstitial lung disease.2021

    • Author(s)
      Maho Nakazawa, Katsuya Suzuki, Masaru Takeshita, Jun Inamo, Tsutomu Takeuchi.
    • Organizer
      第65回日本リウマチ学会総会・学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Antigen-driven autoantibody production in lung lesion of systemic autoimmune diseases.2020

    • Author(s)
      Masaru Takeshita, Katsuya Suzuki, Maho Nakazawa, Tsutomu Takeuchi.
    • Organizer
      第64回日本リウマチ学会総会・学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Differences of coinhibitory molecule expression on lung T cells from patients with rheumatoid arthritis- and idiopathic inflammatory myopathies-associated interstitial lung disease.2020

    • Author(s)
      Maho Nakazawa, Masaru Takeshita, Katsuya Suzuki, Hisaji Oshima, Tsutomu Takeuchi.
    • Organizer
      第64回日本リウマチ学会総会・学術集会
    • Related Report
      2020 Annual Research Report

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Published: 2020-04-28   Modified: 2024-01-30  

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