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Overcoming castration-resistant prostate cancer targeting androgen receptor and epigenome modifications

Research Project

Project/Area Number 20H03813
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 56030:Urology-related
Research InstitutionChiba University

Principal Investigator

Ichikawa Tomohiko  千葉大学, 大学院医学研究院, 教授 (20241953)

Co-Investigator(Kenkyū-buntansha) 金田 篤志  千葉大学, 大学院医学研究院, 教授 (10313024)
坂本 信一  千葉大学, 医学部附属病院, 准教授 (70422235)
Project Period (FY) 2020-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2022: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2021: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2020: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Keywords前立腺癌 / 去勢抵抗性前立腺癌 / アンドロゲン受容体 / スプライスバリアント / スーパーエンハンサー / L型アミノ酸トランスポーター3 / L型アミノ酸トランスポーター1 / 4F2細胞表面抗原重鎖 / FOXA1 / ヒストン修飾
Outline of Research at the Start

前立腺癌は進行癌であってもアンドロゲン除去療法(ADT)が有効である。しかし、その多くはいずれADT無効となり、去勢抵抗性前立腺癌(CRPC)となる。CRPCと密接に関係するアンドロゲン受容体(AR)はクロマチンと結合することで転写が活性化するが、その際FOXA1がクロマチンを開くことが知られている。しかし、FOXA1/AR/クロマチン間におけるヒストン修飾の変化や共役因子の機能などについては、不明な点が多い。本研究ではマスター転写因子であるARを中心に据え、CRPCにおけるエピジェネティックな分子機構の同定ならびに新規治療法を確立することによりCRPCの克服を目指す。

Outline of Final Research Achievements

We analyzed the epigenomic modifications and super-enhancers of the androgen receptor (AR) and its splice variant AR-V7, which are closely associated with castration-resistant prostate cancer (CRPC). We found that the activation of AR/AR-V7 targets contributes to the proliferation of CRPC. We analyzed L-type amino acid transporter 3 (LAT3), which is involved in the development of CRPC, and 4F2 cell surface antigen heavy chain (4F2hc), which forms a heterodimeric complex with LAT1. We clarified the possibility that LAT3 plays an important role in the progression of prostate cancer. Furthermore, we showed that LAT1 may be a therapeutic target for CRPC and other urinary tract malignancies.

Academic Significance and Societal Importance of the Research Achievements

去勢抵抗性前立腺癌(CRPC)と密接に関連するARならびにそのスプライスバリアントAR-V7の解析を進めることによりCRPCの機序に迫ることができたことは、学術的意義の高い大きな研究成果の一つである。また、前立腺癌の進展に関連するLAT1ならびにLAT3についても解析を進め、これらが前立腺癌の進展に重要な役割を果たしていることを明らかにしたこと、特にLAT1がCRPCだけでなく他の尿路悪性腫瘍の治療ターゲットになる可能性を示したことは、学術的意義でだけでなく、癌の克服という社会的意義のある成果である。

Report

(4 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Annual Research Report
  • 2020 Annual Research Report
  • Research Products

    (40 results)

All 2023 2022 2021 2020 Other

All Journal Article (29 results) (of which Int'l Joint Research: 7 results,  Peer Reviewed: 29 results,  Open Access: 20 results) Presentation (10 results) Remarks (1 results)

  • [Journal Article] Deep Learning-Based Seminal Vesicle and Vas Deferens Recognition in the Posterior Approach of Robot-Assisted Radical Prostatectomy2023

    • Author(s)
      Takeshita Nobushige、Sakamoto Shinichi、Kitaguchi Daichi、Takeshita Nobuyoshi、Yajima Shugo、Koike Tatsuki、Ishikawa Yuto、Matsuzaki Hiroki、Mori Kensaku、Masuda Hitoshi、Ichikawa Tomohiko、Ito Masaaki
    • Journal Title

      Urology

      Volume: 173 Pages: 98-103

    • DOI

      10.1016/j.urology.2022.12.006

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Detection of intraductal carcinoma in prostate cancer patients with small tumor volume2023

    • Author(s)
      Takeshita Nobushige、Sakamoto Shinichi、Yamada Yasutaka、Sazuka Tomokazu、Imamura Yusuke、Komiya Akira、Akakura Koichiro、Sato Nobuo、Nakatsu Hiroomi、Kato Takuma、Sugimoto Mikio、Tsuzuki Toyonori、Ichikawa Tomohiko
    • Journal Title

      The Prostate

      Volume: 83 Issue: 6 Pages: 580-589

    • DOI

      10.1002/pros.24492

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Contribution of the L-Type Amino Acid Transporter Family in the Diagnosis and Treatment of Prostate Cancer2023

    • Author(s)
      Zhao Xue、Sakamoto Shinichi、Wei Jiaxing、Pae Sangjon、Saito Shinpei、Sazuka Tomokazu、Imamura Yusuke、Anzai Naohiko、Ichikawa Tomohiko
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 24 Issue: 7 Pages: 6178-6178

    • DOI

      10.3390/ijms24076178

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] External validation of the Candiolo nomogram for high-risk prostate cancer patients treated with carbon ion radiotherapy plus androgen deprivation therapy: a retrospective cohort study2022

    • Author(s)
      Utsumi Takanobu、Suzuki Hiroyoshi、Ishikawa Hitoshi、Hiroshima Yuichi、Wakatsuki Masaru、Harada Masaoki、Ichikawa Tomohiko、Akakura Koichiro、Tsuji Hiroshi
    • Journal Title

      Japanese Journal of Clinical Oncology

      Volume: 52 Issue: 8 Pages: 950-953

    • DOI

      10.1093/jjco/hyac066

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Efficacy of Androgen Receptor-targeted Drugs After Prostate Cancer Recurrence With Bone Metastases: PROSTAT-BSI Sub-analysis2022

    • Author(s)
      KAMIJIMA TAIKI、YAEGASHI HIROSHI、MIZOKAMI ATSUSHI、NAKAJIMA KENICHI、MATSUYAMA HIDEYASU、ICHIKAWA TOMOHIKO、NISHIMOTO KOSHIRO、TAKAHASHI SATORU、SHIINA HIROAKI、HORIKOSHI HIROYUKI、HASHINE KATSUYOSHI、SUGIYAMA YUTAKA、MIYAO TAKESHI、KAMIYAMA MANABU、HARADA KENICHI、ITO AKITO、ENOKIDA HIDEKI
    • Journal Title

      Anticancer Research

      Volume: 42 Issue: 6 Pages: 3099-3108

    • DOI

      10.21873/anticanres.15798

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Extracellular vesicles in bone homeostasis: key roles of physiological and pathological conditions2022

    • Author(s)
      Tamura Takaaki、Yoshioka Yusuke、Sakamoto Shinichi、Ichikawa Tomohiko、Ochiya Takahiro
    • Journal Title

      Journal of Bone and Mineral Metabolism

      Volume: - Issue: 3 Pages: 345-357

    • DOI

      10.1007/s00774-022-01362-2

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Safety and Efficacy of Carbon-Ion Radiotherapy for Elderly Patients with High-Risk Prostate Cancer2022

    • Author(s)
      Hiroshima Yuichi、Ishikawa Hitoshi、Iwai Yuma、Wakatsuki Masaru、Utsumi Takanobu、Suzuki Hiroyoshi、Akakura Koichiro、Harada Masaoki、Sakurai Hideyuki、Ichikawa Tomohiko、Tsuji Hiroshi
    • Journal Title

      Cancers

      Volume: 14 Issue: 16 Pages: 4015-4015

    • DOI

      10.3390/cancers14164015

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Predictive factors for the effectiveness of novel androgen receptor axis‐targeted agents in patients with metastatic prostate cancer2022

    • Author(s)
      Koshiro Nishimoto、Nakajima Kenichi、Oyama Masafumi、Kaneko Go、Takahashi Satoru、Matsuyama Hideyasu、Shiina Hiroaki、Ichikawa Tomohiko、Horikoshi Hiroyuki、Hashine Katsuyoshi、Sugiyama Yutaka、Miyao Takeshi、Kamiyama Manabu、Harada Kenichi、Ito Akito、Mizokami Atsushi、PROSTAT‐BSI Investigators
    • Journal Title

      International Journal of Urology

      Volume: 29 Issue: 12 Pages: 1477-1487

    • DOI

      10.1111/iju.15022

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Targeting L-type amino acid transporter 1 in urological malignancy: Current status and future perspective2022

    • Author(s)
      Pae Sangjon、Sakamoto Shinichi、Zhao Xue、Saito Shinpei、Tamura Takaaki、Imamura Yusuke、Sazuka Tomokazu、Reien Yoshie、Hirayama Yuri、Hashimoto Hirofumi、Kanai Yoshikatsu、Ichikawa Tomohiko、Anzai Naohiko
    • Journal Title

      Journal of Pharmacological Sciences

      Volume: 150 Issue: 4 Pages: 251-258

    • DOI

      10.1016/j.jphs.2022.10.002

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Tumor Location and a Tumor Volume over 2.8 cc Predict the Prognosis for Japanese Localized Prostate Cancer2022

    • Author(s)
      Baba Haruki、Sakamoto Shinichi、Zhao Xue、Yamada Yasutaka、Rii Junryo、Fujimoto Ayumi、Kanesaka Manato、Takeuchi Nobuyoshi、Sazuka Tomokazu、Imamura Yusuke、Akakura Koichiro、Ichikawa Tomohiko
    • Journal Title

      Cancers

      Volume: 14 Issue: 23 Pages: 5823-5823

    • DOI

      10.3390/cancers14235823

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Contribution of LAT1-4F2hc in Urological Cancers via Toll-like Receptor and Other Vital Pathways2022

    • Author(s)
      Zhao Xue、Sakamoto Shinichi、Maimaiti Maihulan、Anzai Naohiko、Ichikawa Tomohiko
    • Journal Title

      Cancers

      Volume: 14 Issue: 1 Pages: 229-229

    • DOI

      10.3390/cancers14010229

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Efficacy of New Therapies for Relapse After Docetaxel Treatment of Bone Metastatic Castration-resistant Prostate Cancer in Clinical Practice2022

    • Author(s)
      MIZOKAMI ATSUSHI、NISHIMOTO KOSHIRO、MATSUYAMA HIDEYASU、ICHIKAWA TOMOHIKO、TAKAHASHI SATORU、SHIINA HIROAKI、HASHINE KATSUYOSHI、SUGIYAMA YUTAKA、KAMIYAMA MANABU、ENOKIDA HIDEKI、NAKAJIMA KENICHI
    • Journal Title

      Anticancer Research

      Volume: 42 Issue: 3 Pages: 1465-1475

    • DOI

      10.21873/anticanres.15617

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Functional inhibition of cancer stemness-related protein DPP4 rescues tyrosine kinase inhibitor resistance in renal cell carcinoma2021

    • Author(s)
      Kamada Shuhei、Namekawa Takeshi、Ikeda Kazuhiro、Suzuki Takashi、Kagawa Makoto、Takeshita Hideki、Yano Akihiro、Okamoto Koji、Ichikawa Tomohiko、Horie-Inoue Kuniko、Kawakami Satoru、Inoue Satoshi
    • Journal Title

      Oncogene

      Volume: 40 Issue: 22 Pages: 3899

    • DOI

      10.1038/s41388-021-01822-5

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Functional analysis of LAT3 in prostate cancer: Its downstream target and relationship with androgen receptor2021

    • Author(s)
      Rii Junryo、Sakamoto Shinichi、Sugiura Masahiro、Kanesaka Manato、Fujimoto Ayumu、Yamada Yasutaka、Maimaiti Maihulan、Ando Keisuke、Wakai Ken、Xu Minhui、Imamura Yusuke、Shindo Norihisa、Hirota Toru、Kaneda Atsushi、Kanai Yoshikatsu、Ikehara Yuzuru、Anzai Naohiko、Ichikawa Tomohiko
    • Journal Title

      Cancer Science

      Volume: 112 Issue: 9 Pages: 3871-3883

    • DOI

      10.1111/cas.14991

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The heavy chain of 4F2 antigen promote prostate cancer progression via SKP-22021

    • Author(s)
      Maimaiti Maihulan、Sakamoto Shinichi、Sugiura Masahiro、Kanesaka Manato、Fujimoto Ayumi、Matsusaka Keisuke、Xu Minhui、Ando Keisuke、Saito Shinpei、Wakai Ken、Imamura Yusuke、Nakayama Keiichi、Kanai Yoshikatsu、Kaneda Atsushi、Ikehara Yuzuru、Ikeda Jun-Ichiro、Anzai Naohiko、Ichikawa Tomohiko
    • Journal Title

      Scientific Reports

      Volume: 11 Issue: 1 Pages: 11478-11478

    • DOI

      10.1038/s41598-021-90748-9

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Prognosis of patients with prostate cancer and bone metastasis from the Japanese Prostatic Cancer Registry of Standard Hormonal and Chemotherapy Using Bone Scan Index cohort study2021

    • Author(s)
      Nakajima Kenichi、Mizokami Atsushi、Matsuyama Hideyasu、Ichikawa Tomohiko、Kaneko Go、Takahashi Satoru、Shiina Hiroaki、Horikoshi Hiroyuki、Hashine Katsuyoshi、Sugiyama Yutaka、Miyao Takeshi、Kamiyama Manabu、Harada Kenichi、Ito Akito、PROSTAT‐BSI Investigators
    • Journal Title

      International Journal of Urology

      Volume: 28 Issue: 9 Pages: 955-963

    • DOI

      10.1111/iju.14614

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Clinicopathological and Preclinical Patient-Derived Model Studies Define High Expression of NRN1 as a Diagnostic and Therapeutic Target for Clear Cell Renal Cell Carcinoma2021

    • Author(s)
      Kamada Shuhei、Ikeda Kazuhiro、Suzuki Takashi、Sato Wataru、Kitayama Sachi、Kawakami Satoru、Ichikawa Tomohiko、Horie Kuniko、Inoue Satoshi
    • Journal Title

      Frontiers in Oncology

      Volume: 11 Pages: 758503-758503

    • DOI

      10.3389/fonc.2021.758503

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Revision of CHAARTED and LATITUDE criteria among Japanese de novo metastatic prostate cancer patients2021

    • Author(s)
      Kanesaka Manato、Sakamoto Shinichi、Yamada Yasutaka、Rii Junryo、Maimaiti Maihulan、Sazuka Tomokazu、Imamura Yusuke、Komiya Akira、Akakura Koichiro、Ikehara Yuzuru、Nakatsu Hiroomi、Ichikawa Tomohiko
    • Journal Title

      Prostate International

      Volume: 9 Issue: 4 Pages: 208-214

    • DOI

      10.1016/j.prnil.2021.06.001

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Identification of AR-V7 downstream genes commonly targeted by AR/AR-V7 and specifically targeted by AR-V7 in castration resistant prostate cancer2021

    • Author(s)
      Sugiura Masahiro、Sato Hiroaki、Okabe Atsushi、Fukuyo Masaki、Mano Yasunobu、Shinohara Ken-ichi、Rahmutulla Bahityar、Higuchi Kosuke、Maimaiti Maihulan、Kanesaka Manato、Imamura Yusuke、Furihata Tomomi、Sakamoto Shinichi、Komiya Akira、Anzai Naohiko、Kanai Yoshikatsu、Luo Jun、Ichikawa Tomohiko、Kaneda Atsushi
    • Journal Title

      Translational Oncology

      Volume: 14 Issue: 1 Pages: 100915-100915

    • DOI

      10.1016/j.tranon.2020.100915

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Prognostic Value of High-Sensitivity Modified Glasgow Prognostic Score in Castration-Resistant Prostate Cancer Patients Who Received Docetaxel2021

    • Author(s)
      Ando Keisuke、Sakamoto Shinichi、Saito Shinpei、Maimaiti Maihulan、Imamura Yusuke、Sazuka Tomokazu、Sato Nobuo、Komiya Akira、Anzai Naohiko、Ichikawa Tomohiko
    • Journal Title

      Cancers

      Volume: 13 Issue: 4 Pages: 773-773

    • DOI

      10.3390/cancers13040773

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Replisome genes regulation by antitumor miR-101-5p in clear cell renal cell carcinoma2020

    • Author(s)
      Yamada Yasutaka、Nohata Nijiro、Uchida Akifumi、Kato Mayuko、Arai Takayuki、Moriya Shogo、Mizuno Keiko、Kojima Satoko、Yamazaki Kazuto、Naya Yukio、Ichikawa Tomohiko、Seki Naohiko
    • Journal Title

      Cancer Science

      Volume: 111 Issue: 4 Pages: 1392

    • DOI

      10.1111/cas.14327

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] How many bone metastases may be defined as high‐volume metastatic prostate cancer in Asians: A retrospective multicenter cohort study2020

    • Author(s)
      Yamada Yasutaka、Sakamoto Shinichi、Rii Junryo、Yamamoto Satoshi、Kamada Shuhei、Imamura Yusuke、Nakamura Kazuyoshi、Komiya Akira、Nakatsu Hiroomi、Ichikawa Tomohiko
    • Journal Title

      The Prostate

      Volume: 80 Issue: 5 Pages: 559-569

    • DOI

      10.1002/pros.23958

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Prognostic value of an inflammatory index for patients with metastatic castration‐resistant prostate cancer2020

    • Author(s)
      Yamada Yasutaka、Sakamoto Shinichi、Rii Junryo、Yamamoto Satoshi、Kamada Shuhei、Imamura Yusuke、Nakamura Kazuyoshi、Komiya Akira、Nakatsu Hiroomi、Ichikawa Tomohiko
    • Journal Title

      The Prostate

      Volume: 80 Issue: 7 Pages: 559-569

    • DOI

      10.1002/pros.23969

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Prognostic factors influencing overall survival in de novo oligometastatic prostate cancer patients2020

    • Author(s)
      Rii Junryo、Sakamoto Shinichi、Yamada Yasutaka、Takeshita Nobushige、Yamamoto Satoshi、Sazuka Tomokazu、Imamura Yusuke、Nakamura Kazuyoshi、Komiya Akira、Komaru Atsushi、Fukasawa Satoshi、Nakatsu Hiroomi、Akakura Koichiro、Ichikawa Tomohiko
    • Journal Title

      The Prostate

      Volume: 80 Issue: 11 Pages: 850-858

    • DOI

      10.1002/pros.24016

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] HIF1α inhibitor 2-methoxyestradiol decreases NRN1 expression and represses in vivo and in vitro growth of patient-derived testicular germ cell tumor spheroids2020

    • Author(s)
      Namekawa Takeshi、Kitayama Sachi、Ikeda Kazuhiro、Horie-Inoue Kuniko、Suzuki Takashi、Okamoto Koji、Ichikawa Tomohiko、Yano Akihiro、Kawakami Satoru、Inoue Satoshi
    • Journal Title

      Cancer Letters

      Volume: 489 Pages: 79

    • DOI

      10.1016/j.canlet.2020.05.040

    • URL

      https://pure.teikyo.jp/en/publications/ae8f66d6-e232-43e3-aee1-e16539dd567b

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The impact of complications after initial prostate biopsy on repeat protocol biopsy acceptance rate. Results from the Prostate Cancer Research International: Active Surveillance JAPAN study2020

    • Author(s)
      Tohi Y, Kato T, Matsumoto R, Shinohara N, Shiga K, Yokomizo A, Nakamura M, Kume H, Mitsuzuka K, Sasaki H, Egawa S, Matsumura M, Hashine K, Inokuchi J, Eto M, Baba H, Ichikawa T, Kinoshita H, Matsuda T, Kakehi Y, Sugimoto M.
    • Journal Title

      International Journal of Clinical Oncology

      Volume: 25 Issue: 12 Pages: 2107-2114

    • DOI

      10.1007/s10147-020-01761-3

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Extracellular Vesicles in Bone Metastasis: Key Players in the Tumor Microenvironment and Promising Therapeutic Targets2020

    • Author(s)
      Tamura Takaaki、Yoshioka Yusuke、Sakamoto Shinichi、Ichikawa Tomohiko、Ochiya Takahiro
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 21 Issue: 18 Pages: 6680-6680

    • DOI

      10.3390/ijms21186680

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Epigenetic modifications in prostate cancer2020

    • Author(s)
      Sugiura Masahiro、Sato Hiroaki、Kanesaka Manato、Imamura Yusuke、Sakamoto Shinichi、Ichikawa Tomohiko、Kaneda Atsushi
    • Journal Title

      International Journal of Urology

      Volume: 28 Issue: 2 Pages: 140-149

    • DOI

      10.1111/iju.14406

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of oncogenic targets by the tumor-suppressive mir-139 duplex (Mir-139-5p and mir-139-3p) in renal cell carcinoma2020

    • Author(s)
      Okada Reona、Goto Yusuke、Yamada Yasutaka、Kato Mayuko、Asai Shunichi、Moriya Shogo、Ichikawa Tomohiko、Seki Naohiko
    • Journal Title

      Biomedicines

      Volume: 8 Issue: 12 Pages: 1

    • DOI

      10.3390/biomedicines8120599

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 前立腺がん細胞に教育された破骨細胞由来細胞外小胞の骨形成への影響2022

    • Author(s)
      田村 貴明, 木暮 暁子, 吉岡 祐亮, 坂本 信一, 市川 智彦, 落谷 孝広
    • Organizer
      第81回日本癌学会学術総会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 去勢抵抗性前立腺癌におけるFOXA1を介したエピジェネティックな糖代謝変化機構の同定2022

    • Author(s)
      金坂 学斗, 星居 孝之, 岡部 篤史, 佐藤 広明, 福世 真樹, 繩井 バハテヤリラヒムトラ, 金岡 尚志, 坂本 信一, 市川 智彦, 金田 篤志
    • Organizer
      第81回日本癌学会学術総会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 前立腺がん去勢抵抗性を獲得時に起こるクロマチン構造変化の網羅的解析2022

    • Author(s)
      金岡 尚志, 金坂 学斗, 岡部 篤史, 星居 孝之, 福世 真樹, 繩井 バハテヤリラヒムトラ, 坂本 信一, 市川 智彦, 金田 篤志
    • Organizer
      第81回日本癌学会学術総会
    • Related Report
      2022 Annual Research Report
  • [Presentation] アミノ酸トランスポーターLAT1はカバジタキセル耐性前立腺癌においてCDK1とCDK2を介して細胞増殖に寄与する2022

    • Author(s)
      梨井 隼菱, 坂本 信一, 溝上 敦, 安西 尚彦, 金井 好克, 市川 智彦
    • Organizer
      第81回日本癌学会学術総会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 去勢抵抗性前立腺癌におけるアミノ酸トランスポーターLAT1選択的阻害薬JPH203の効果2022

    • Author(s)
      坂本 信一, 齋藤 心平, 安藤 敬介, 梨井 隼菱, 徐 旻恵, 金井 好克, 安西 尚彦, 市川 智彦
    • Organizer
      第81回日本癌学会学術総会
    • Related Report
      2022 Annual Research Report
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    • Author(s)
      金坂 学斗、佐藤 広明、星居 孝之、岡部 篤史、福世 真樹、縄井 バハテヤリ・ラヒムトラ、坂本 信一、小宮 顕、市川 智彦、金田 篤志
    • Organizer
      第80回日本癌学会学術総会
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  • [Presentation] 前立腺癌における去勢抵抗性獲得とクロマチン高次構造の変化との関係について2021

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      金岡 尚志、岡部 篤史、金坂 学斗、星居 孝之、福世 真樹、縄井 バハテヤリ・ラヒムトラ、坂本 信一、小宮 顕、市川 智彦、金田 篤志
    • Organizer
      第80回日本癌学会学術総会
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      2021 Annual Research Report
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      梨井 隼菱、坂本 信一、杉浦 正洋、金坂 学斗、若井 健、金田 篤志、池原 譲、安西 尚彦、金井 好克、市川 智彦
    • Organizer
      第109回日本泌尿器科学会総会
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    • Author(s)
      金坂学斗、佐藤広明、杉浦正洋、星居孝之、岡部篤史、福世真樹、坂本信一、小宮 顕、市川智彦、金田篤志
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      第79回日本癌学会学術集会
    • Related Report
      2020 Annual Research Report
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    • Author(s)
      佐藤広明、金坂学斗、杉浦正洋、福世真樹、岡部篤史、星居孝之、坂本信一、小宮 顕、市川智彦、金田篤志
    • Organizer
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    • Related Report
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  • [Remarks] 千葉大学大学院医学研究院泌尿器科学

    • URL

      http://www.m.chiba-u.ac.jp/class/urology/

    • Related Report
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Published: 2020-04-28   Modified: 2024-01-30  

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