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Elucidation of the interaction between epithelium and stroma that regulates cancer development using mouse models

Research Project

Project/Area Number 20H03822
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 56040:Obstetrics and gynecology-related
Research InstitutionKanazawa University

Principal Investigator

Daikoku Takiko  金沢大学, 疾患モデル総合研究センター, 教授 (30767249)

Co-Investigator(Kenkyū-buntansha) 藤原 浩  金沢大学, 医学系, 教授 (30252456)
吉江 幹浩  東京薬科大学, 薬学部, 准教授 (50434014)
馬場 長  岩手医科大学, 医学部, 教授 (60508240)
三上 芳喜  熊本大学, 病院, 教授 (90248245)
Project Period (FY) 2020-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2022: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2021: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2020: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Keywordsマウスモデル / 子宮がん
Outline of Research at the Start

子宮体癌および子宮肉腫の発生に関わると考えられる上皮・間質細胞間の相互応答因子の探索とその分子機構の解明を、がん自然発症マウスモデルを用いて行うことによって新たな治療標的と治療法の開発を試みる。

Outline of Final Research Achievements

The researchers in this study have so far created mouse models that spontaneously develop uterine epithelial hyperplasia, endometrial cancer, and uterine sarcoma using mice with site-specific deletion of the Pten gene. In this study, we used these mouse models to analyze the effects of ovarian hormones on the mutual response of the uterus and stroma. We also examined the differences in gene expression in the stroma or epithelium to find epithelial effectors for epithelial hyperplasia and endometrial cancers, and stromal factors for sarcoma. We found candidate stromal factors involved in the development of endometrial cancer and candidate epithelial factors involved in the development of uterine sarcoma, and clarified some of their mechanisms of action.

Academic Significance and Societal Importance of the Research Achievements

癌の浸潤・転移に間質細胞との相互作用が重要であることは広く知られているが、癌の発生における上皮・間質細胞間の相互応答の役割は不明な点が多く、また肉腫の発生・進展に対する上皮細胞の関与もほとんど報告がない。本研究で新たに発見された子宮がん発生・進展を促進あるいは抑制に関わると考えられる上皮もしくは間質の因子は、子宮がんの新たな治療ターゲットとなり、新規治療薬の開発につながると考えられ、社会的意義がある。

Report

(2 results)
  • 2022 Final Research Report ( PDF )
  • 2020 Annual Research Report
  • Research Products

    (5 results)

All 2021 2020

All Journal Article (5 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 5 results,  Open Access: 5 results)

  • [Journal Article] Mucinous, endometrioid, and serous ovarian cancers with peritoneal dissemination are potent candidates for P-cadherin targeted therapy: a retrospective cohort study2021

    • Author(s)
      Kayahashi Kayo、Mizumoto Yasunari、Matsuoka Ayumi、Obata Takeshi、Iwadare Junpei、Nakamura Mitsuhiro、Daikoku Takiko、Fujiwara Hiroshi
    • Journal Title

      BMC Cancer

      Volume: 21 Issue: 1 Pages: 1-9

    • DOI

      10.1186/s12885-020-07737-w

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Brown adipocyte-specific knockout of Bmal1 causes mild but significant thermogenesis impairment in mice2021

    • Author(s)
      Hasan Nazmul、Nagata Naoto、Morishige Jun-ichi、Islam Md Tarikul、Jing Zheng、Harada Ken-ichi、Mieda Michihiro、Ono Masanori、Fujiwara Hiroshi、Daikoku Takiko、Fujiwara Tomoko、Maida Yoshiko、Ota Tsuguhito、Shimba Shigeki、Kaneko Shuichi、Fujimura Akio、Ando Hitoshi
    • Journal Title

      Molecular Metabolism

      Volume: 49 Pages: 101202-101202

    • DOI

      10.1016/j.molmet.2021.101202

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Adolescent Dietary Habit-induced Obstetric and Gynecologic Disease (ADHOGD) as a New Hypothesis?Possible Involvement of Clock System2020

    • Author(s)
      Fujiwara Tomoko, Ono Masanori, Mieda Michihiro, Yoshikawa Hiroaki, Nakata Rieko, Daikoku Takiko, Sekizuka-Kagami Naomi, Maida Yoshiko, Ando Hitoshi, Fujiwara Hiroshi
    • Journal Title

      Nutrients

      Volume: 12 Issue: 5 Pages: 1294-1294

    • DOI

      10.3390/nu12051294

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Hypertensive disorders of pregnancy are associated with dysmenorrhea in early adulthood: A cohort study2020

    • Author(s)
      Nakayama Midori, Ono Masanori, Iizuka Takashi, Kagami Kyosuke, Fujiwara Tomoko, Sekizuka‐Kagami Naomi, Maida Yoshiko, Obata Takeshi, Yamazaki Rena, Daikoku Takiko, Fujiwara Hiroshi
    • Journal Title

      Journal of Obstetrics and Gynaecology Research

      Volume: 46 Issue: 11 Pages: 2292-2297

    • DOI

      10.1111/jog.14431

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The lack of terminal tubule cells in the submandibular gland of mice deficient in submandibular gland protein C2020

    • Author(s)
      Nakata H, Terakawa J, Horike S, Daikoku T, Iseki S
    • Journal Title

      Cell and Tissue Research

      Volume: 381(2) Issue: 2 Pages: 229-237

    • DOI

      10.1007/s00441-020-03205-w

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access

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Published: 2020-04-28   Modified: 2024-01-30  

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