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Research on the clinical pathology of auditory attention mechanisms

Research Project

Project/Area Number 20H03831
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 56050:Otorhinolaryngology-related
Research InstitutionTohoku University

Principal Investigator

Kawase Tetsuaki  東北大学, 医学系研究科, 大学院非常勤講師 (50169728)

Co-Investigator(Kenkyū-buntansha) 菅野 彰剛  東北大学, 工学研究科, 特任教授 (20578968)
坂本 修一  東北大学, 電気通信研究所, 教授 (60332524)
Project Period (FY) 2020-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2023: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2022: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2021: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2020: ¥9,880,000 (Direct Cost: ¥7,600,000、Indirect Cost: ¥2,280,000)
Keywords聴覚的注意 / 脳磁図 / 眼球計測 / inattentional deafness / attentional deafness / マイクロサッケード / 瞳孔径
Outline of Research at the Start

多数の音源が存在する日常生活での音情報の知覚・認知に必要不可欠となる、聴覚的注意・無視メカニズムの病理に関する研究計画。聴覚的注意に関する研究は、主に正常人を対象に行われてきたが、本研究では、選択的注意・無視メカニズムの不全の関与が疑われる聴覚情報処理障害患者、耳鳴患者を対象に、注意・無視メカニズム不全の可視化と機序解明を行い、同不全が関与する臨床病理の診断法確立、さらには治療アプローチへの提言考察を行うとともに、健常人データとの比較により、ヒト聴覚選択的注意機構の意義解明という本質的なテーマにも迫る。

Outline of Final Research Achievements

Regarding the visualization of the pathology of the attentional mechanism and the elucidation of its mechanism, the following findings were obtained: 1) it is suggested that the informational masking mechanisms may be involved in the masking effects observed in patients with listening difficulties (LiD); 2) the use of steady-state noise (e.g. white noise and/or speech noise etc.) as a masker for speech intelligibility testing may underestimate the degree of listening problems of patients with LiD, 3) the use of everyday environmental sounds such as music and speech as a masker is recommended to visualize the symptoms of speech intelligibility in LiD patients, 4) there is a synergistic effect between auditory and visual stimuli that interfere the attention, 5) there is a strong correlation between listening ability in noisy environment and the selective attention ability.

Academic Significance and Societal Importance of the Research Achievements

Listening difficulties患者の聞き取り困難症状においては、選択的注意の問題が関連したinformational maskingメカニズムの関与の重要であることが明確に示されたが、本知見は、本症の注意障害に起因する聞き取り障害に対する臨床診断法の確立、治療アプローチの提言のための重要、かつ新規的な基礎的知見となる。
今回得られた知見の社会実装展開などにより、Listening difficultiesや、耳鳴などの注意メカニズムが関連した聴覚病理に対する診断、治療両面での新規的なアプローチが期待される。

Report

(5 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Annual Research Report
  • 2021 Annual Research Report
  • 2020 Annual Research Report
  • Research Products

    (15 results)

All 2024 2023 2022 2021

All Journal Article (6 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 5 results,  Open Access: 1 results) Presentation (9 results) (of which Invited: 3 results)

  • [Journal Article] Listening difficulties (いわゆる聴覚情報処理障害)ー病態概念と臨床的課題についてー2024

    • Author(s)
      川瀬哲明
    • Journal Title

      都耳鼻会報

      Volume: 173 Pages: 23-27

    • Related Report
      2023 Annual Research Report
  • [Journal Article] Possibility of additive effects by the presentation of visual information related to distractor sounds on the contra-sound effects of the N100m responses2023

    • Author(s)
      Takai Shunsuke、Kanno Akitake、Kawase Tetsuaki、Shirakura Masayuki、Suzuki Jun、Nakasato Nobukatsu、Kawashima Ryuta、Katori Yukio
    • Journal Title

      Hearing Research

      Volume: 434 Pages: 108778-108778

    • DOI

      10.1016/j.heares.2023.108778

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 聴性誘発脳磁界 (N1m)2022

    • Author(s)
      白倉 真之, 川瀬 哲明, 菅野 彰剛, 太田 淳, 中里 信和, 川島 隆太, 香取 幸夫
    • Journal Title

      Japanese Journal of Clinical Neurophysiology

      Volume: 50 Issue: 4 Pages: 138-142

    • DOI

      10.11422/jscn.50.138

    • ISSN
      1345-7101, 2188-031X
    • Year and Date
      2022-08-01
    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Temporal and Directional Cue Effects on the Cocktail Party Problem for Patients With Listening Difficulties Without Clinical Hearing Loss2022

    • Author(s)
      Kawase Tetsuaki、Teraoka Ryo、Obuchi Chie、Sakamoto Shuichi
    • Journal Title

      Ear and Hearing

      Volume: 43 Issue: 6 Pages: 1740-1751

    • DOI

      10.1097/aud.0000000000001247

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Auditory Attention Ability under Dichotic Dual-Task Situation in Adults with Listening Difficulties2022

    • Author(s)
      Obuchi Chie、Kawase Tetsuaki、Kaga Kimitaka、Noguchi Yoshihiro
    • Journal Title

      Audiology and Neurotology

      Volume: 27 Issue: 3 Pages: 1-8

    • DOI

      10.1159/000528050

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Different contra-sound effects between noise and music stimuli seen in N1m and psychophysical responses.2021

    • Author(s)
      Masayuki Shirakura, Tetsuaki Kawase, Akitake Kanno, Jun Ohta, Nobukazu Nakasato, Ryuta Kawashima, Yukio Katori
    • Journal Title

      PLoS One

      Volume: 16 Issue: 12 Pages: e0261637-e0261637

    • DOI

      10.1371/journal.pone.0261637

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 雑音下での聴取と主観的な聞こえにくさの関係 高齢者、Listening Difficulties、健聴例の比較から2023

    • Author(s)
      山本 弥生, 小渕 千絵, 川瀬 哲明, 笹目 友香, 戸林 沙織, 野口 佳裕
    • Organizer
      日本聴覚医学会
    • Related Report
      2023 Annual Research Report
  • [Presentation] 聴覚検査でListening Difficultiesが鑑別しにくいのはなぜか? 聴覚二重課題成績の差異とその要因の検討2023

    • Author(s)
      小渕 千絵, 川瀬 哲明, 笹目 友香, 山本 弥生, 岡本 秀彦, 野口 佳裕
    • Organizer
      日本聴覚医学会
    • Related Report
      2023 Annual Research Report
  • [Presentation] 聞き取り困難を呈する成人小児に対する聴覚情報処理検査の検出率 AMED研究からの報告2023

    • Author(s)
      阪本 浩一, 川瀬 哲明, 岡本 康秀, 片岡 祐子, 土橋 奈々, 中川 尚志, 加我 君孝, 小渕 千絵, 坂本 圭, 關戸 智惠
    • Organizer
      日本聴覚医学会
    • Related Report
      2023 Annual Research Report
  • [Presentation] Listening difficulties (いわゆる聴覚情報処理障害) ー病態概念と臨床的課題についてー2023

    • Author(s)
      川瀬哲明
    • Organizer
      東京都耳鼻咽喉科医会学術講演会
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] "Listening Difficulties (LiD)"の鑑別診断 Hidden Hearing Lossとの鑑別を中心に2022

    • Author(s)
      川瀬 哲明
    • Organizer
      日本聴覚医学会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 聞き取り困難の病理と"Listening Difficulties(LiD)"2022

    • Author(s)
      川瀬 哲明
    • Organizer
      日本聴覚医学会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 聴性誘発脳磁界N100m反応に認められる音楽による対側耳マスキング効果2021

    • Author(s)
      白倉 真之, 川瀬 哲明, 菅野 彰剛, 太田 淳, 中里 信和, 川島 隆太, 香取 幸夫
    • Organizer
      臨床神経生理学会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 聴覚情報処理障害における標準注意検査2021

    • Author(s)
      佐々木 志保, 鈴木 佑佳, 川瀬 哲明, 小渕 千絵
    • Organizer
      日本聴覚医学会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 聴覚情報処理障害の聞き取り困難に関する一考察 選択的注意に関連したスペクトラム障害としての一側面?2021

    • Author(s)
      川瀬 哲明, 佐々木 志保, 小渕 千絵, 坂本 修一
    • Organizer
      日本聴覚医学会
    • Related Report
      2021 Annual Research Report

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Published: 2020-04-28   Modified: 2025-01-30  

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