Treatment strategies for oral squamous cell carcinoma based on genetic alterlations
| Project/Area Number |
20H03890
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Review Section |
Basic Section 57060:Surgical dentistry-related
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| Research Institution | Ehime University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
合田 啓之 愛媛大学, 医学部附属病院, 講師 (00464371)
徳善 紀彦 愛媛大学, 医学部附属病院, 助教 (10723843)
内田 大亮 愛媛大学, 医学系研究科, 教授 (20335798)
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| Project Period (FY) |
2020-04-01 – 2023-03-31
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| Project Status |
Completed (Fiscal Year 2022)
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| Budget Amount *help |
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2022: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2021: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000)
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| Keywords | 口腔扁平上皮癌 / 遺伝子異常 / 頸部リンパ節転移予測 / リッキドバイオプシー / ゲノム異常 / エピゲノム異常 / 転移予測 / リンパ節転移予測 / 核酸創薬 / リキッドバイオプシー / 再発監視 |
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| Outline of Research at the Start |
がんは、遺伝子異常により生じることが広く知られている。口腔がんも例外ではなく、遺伝子の異常が多数報告されている。しかしながら、このような知見は実際の日常診療では全く活用されていないのが現状である。そこで、本研究ではこれまでにわれわれが明らかにしてきた遺伝子異常に基づいた口腔がんに対する新規治療戦略を確立することを目的とする。すなわち、頸部リンパ節転移予測、再発監視、再発・転移難治性がんに対する新規治療法に遺伝子異常所見を活用することにより、口腔がんの完全制御を目指す。
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| Outline of Final Research Achievements |
It is widely known that human malignancies are caused by genomic and epigenomic alterations. Therefore, we have attempted to identify gene alterations that would be useful in the diagnosis and treatment of oral squamous cell carcinoma. We extracted genomic DNA and total RNA from the primary tumor and adjacent normal tissues, and performed gene mutation analysis using targeted deep sequencing and comprehensive gene expression analysis by microarray. In the mutation analysis, mutations in TP53 gene were observed in 90% of the cases. On the other hand, the expression analysis revealed numerous genes that showed significant correlations with cervical lymph node metastasis and distant metastasis. These gene alterations have the potential to be useful for predicting metastasis and monitoring recurrence for oral squamous cell carcinoma.
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| Academic Significance and Societal Importance of the Research Achievements |
わが国では超高齢社会の到来とともに口腔扁平上皮癌の罹患数は増加しており、2019 年の時点で年間約 11,000 人とされ、5 年生存率は約 60% にとどまっている。本研究成果により、口腔癌診療に遺伝子異常所見が用いられるようになれば、潜在性頸部リンパ節転移や微小残存病変の把握、さらに有効な分子標的薬の選択が可能となり、適切な治療法による治療成績の飛躍的な向上が期待できる。また、無益な治療の回避により患者の治療後の生活の質が担保できる。
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Report
(4 results)
Research Products
(25 results)
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[Journal Article] Molecular and histopathological analysis of peripheral ameloblastoma of the mandible mimicking a papillomatous lesion on the buccal mucosa2022
Author(s)
Izumi S, Komiyama Y, Shimura M, Sawatani Y, Oshima R, Zama M, Fukumoto C, Kamimura R, Yaguchi E, Wakui T, Nakashiro K, Uchida D, Kawamata H
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Journal Title
J Oral Maxillofac Surg Med Pathol
Volume: 34
Pages: 359-363
Related Report
Peer Reviewed
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[Journal Article] Oral squamous cell carcinoma may originate from bone marrow-derived stem cells2021
Author(s)
Hasegawa T, Nakashiro KI, Fukumoto C, Hyodo T, Sawatani Y, Shimura M, Kamimura R, Kuribayashi N, Fujita A, Uchida D, Kawamata H.
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Journal Title
Oncol Lett
Volume: 21
Issue: 2
Pages: 170-170
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Whole Exome Sequencing of SMO, BRAF, PTCH1 and GNAS in Odontogenic Diseases.2020
Author(s)
Shimura M, Nakashiro KI, Sawatani Y, Hasegawa T, Kamimura R, Izumi S, Komiyama Y, Fukumoto C, Yagisawa S, Yaguchi E, Hitomi-Koide M, Hyodo T, Uchida D, Kawamata H.
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Journal Title
In Vivo
Volume: 34
Issue: 6
Pages: 3233-3240
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Paclitaxel Potentiates the Anticancer Effect of Cetuximab by Enhancing Antibody-Dependent Cellular Cytotoxicity on Oral Squamous Cell Carcinoma Cells In Vitro.2020
Author(s)
Sawatani Y, Komiyama Y, Nakashiro KI, Uchida D, Fukumoto C, Shimura M, Hasegawa T, Kamimura R, Hitomi-Koide M, Hyodo T, Kawamata H.
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Journal Title
Int J Mol Sci.
Volume: 21
Issue: 17
Pages: 6292-6292
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Valve Interstitial Cell-Specific Cyclooxygenase-1 Associated With Calcification of Aortic Valves.2019
Author(s)
Sakaue T, Hamaguchi M, Aono J, Nakashiro KI, Shikata F, Kawakami N, Oshima Y, Kurata M,?Nanba D, Masumoto J, Yamaguchi O, Higashiyama S, Izutani H.
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Journal Title
Ann Thorac Surg
Volume: S0003-4975
Issue: 1
Pages: 31717-5
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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