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Elucidating pathogenesis of Indium Lung by High-resolution CT

Research Project

Project/Area Number 20H03931
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 58020:Hygiene and public health-related: including laboratory approach
Research InstitutionKochi University

Principal Investigator

Suganuma Narufumi  高知大学, 教育研究部医療学系連携医学部門, 教授 (50313747)

Co-Investigator(Kenkyū-buntansha) 中野 真規子  慶應義塾大学, 医学部(信濃町), 講師 (70384906)
審良 正則  独立行政法人国立病院機構近畿中央呼吸器センター, 臨床研究センター, 放射線部長 (20393267)
Project Period (FY) 2020-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2022: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2021: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2020: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
Keywordsインジウム / 肺疾患 / 高分解能CT / びまん性肺疾患 / 動物モデル / 吸入性病変 / インジウム肺 / 画像診断 / 毒性学 / 高分解能CT (HRCT) / 人工知能(AI) / コホート / 動物実験 / 職業性肺疾患 / 病態 / 人口知能 (AI)
Outline of Research at the Start

インジウムの需要は世界的に伸びる一方、取扱作業中の曝露による呼吸器疾患(インジウム肺)の病態は未解明で、低曝露でも比較的速く進行する可能性や発がん性も指摘されている。本研究では、①形態変化を高解像度に描出できる高分解能CT (HRCT)とHRCT読影用人工知能(AI)を用い、インジウム曝露者コホートのCT画像所見を分析し予測因子の特定;②動物実験と患者の肺生検試料を用いた放射線医学・臨床・病理学対比(radiologic-clinico-pathologic correlation)による詳細な検討し、総合的にインジウム肺の形態学的特徴を把握し、その進行過程や予測因子を含む病態を解明する。

Outline of Final Research Achievements

We have re-evaluated chest CT images of Indium exposed workers focusing on Crazy paving, a typical finding of alveolar proteinosis, interstitial lines, seen in interstitial pneumonias, and centrilobular opacities, typical findings for inhalation diseases. As our cohort is that of exposed workers, we have investigated very early pulmonary manifestation caused by Indium inhalation. Animal model for indium lung was prepared using mice and histological examination was done.

Academic Significance and Societal Importance of the Research Achievements

インジウム肺については、半減期が比較的長いこと、 低曝露でも症状の進行が早いことがわかってきたが、その病態は未解明で、胸部画 像の所見についての日米研究グループの見解は (1) 間質性肺炎に合併する肺気腫(日本) 、 (2) 肺胞蛋白症(PAP)に類似(米国)と分かれている。 この間質性・気腫性変化と肺胞蛋白症の病態の相違は、患者背景(曝露期間や量・血清イ ンジウム濃度・抗GM-CSF中和抗体の有無等)に寄る可能性も高く、その病態解明のために は、HRCTを駆使した放射線医学的な分析を中心とし、肺機能、血液や組織など臨床・病理データ の分析も同時に行い、包括的に分析することが重要である。

Report

(4 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Annual Research Report
  • 2020 Annual Research Report
  • Research Products

    (7 results)

All 2023 2022 2020

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Open Access: 4 results) Presentation (3 results) (of which Invited: 1 results)

  • [Journal Article] Imaging diagnosis of pneumoconiosis with predominant nodular pattern: HRCT and pathologic findings2023

    • Author(s)
      Masanori Akira, Narufumi Suganuma
    • Journal Title

      Clinical Imaging

      Volume: 97 Pages: 28-33

    • DOI

      10.1016/j.clinimag.2023.02.010

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Perceptual and objective physical quality of chest images: a comparison between digital radiographic chest images processed for cancer screening and pneumoconiosis screening in Japan2023

    • Author(s)
      Ryo Akima, Naw Awn JP, Kenji Ito, Shoko Nogami, Miki Nishimori, Kenta Oogi, Naoya Hayashi, Narufumi Suganuma, Takushi Yamagami, NFIHO
    • Journal Title

      Industrial Health

      Volume: 61 Issue: 4 Pages: 260-268

    • DOI

      10.2486/indhealth.2022-0046

    • ISSN
      0019-8366, 1880-8026
    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Autoimmune Pulmonary Alveolar Proteinosis Complicated with Sarcoidosis: the Clinical Course and Serum Levels of Anti-granulocyte-macrophage colony-stimulating Factor Autoantibody2020

    • Author(s)
      Arai T., Kasai T., Shimizu K., Kawahara K., Katayama K., Sugimoto C., Hirose M., Okamoto H., Tachibana K., Akira M., Inoue Y.
    • Journal Title

      Internal Medicine

      Volume: 59 Issue: 20 Pages: 2539-2546

    • DOI

      10.2169/internalmedicine.3853-19

    • NAID

      130007926276

    • ISSN
      0918-2918, 1349-7235
    • Year and Date
      2020-10-15
    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Radiographic diagnosis of Pneumoconioses by AIR Pneumo-trained physicians: Comparison with low-dose thin-slice computed tomography2020

    • Author(s)
      Shoko Nogami, Naw Awn J-P, Munenobu Nogami, Tomomi Matsui, Nlandu Roger Ngatu, Taro Tamura, Yukinori Kusaka, Harumi Itoh, Narufumi Suganuma
    • Journal Title

      Journal of Occupational Health

      Volume: 62 Issue: 1 Pages: n/a

    • DOI

      10.1002/1348-9585.12141

    • NAID

      130007907538

    • ISSN
      1341-9145, 1348-9585
    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 酸化インジウム点鼻投与によるインジウム肺モデルマウスの作成2022

    • Author(s)
      山﨑慶子,丸尾奈生、栄徳勝光、矢生健一、菅沼成文
    • Organizer
      第92回日本衛生学会学術総会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 酸化インジウム投与により作成されたインジウム肺モデルマウスと酸化ストレスの関連2022

    • Author(s)
      山﨑慶子、丸尾奈生、栄徳勝光、矢生健一、荻野景規、菅沼成文
    • Organizer
      第95回日本産業衛生学会学術総会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Digitalized Pneumoconioses and New Occupational Lung Diseases2020

    • Author(s)
      Narufumi Suganuma
    • Organizer
      17th Scientific Respiratory Medicine Meeting 2020
    • Related Report
      2020 Annual Research Report
    • Invited

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Published: 2020-04-28   Modified: 2024-01-30  

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