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Development of perinatal self-care program based on regulation of circadian rhythm

Research Project

Project/Area Number 20H03996
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 58070:Lifelong developmental nursing-related
Research InstitutionKanazawa University

Principal Investigator

Maida Yoshiko  金沢大学, 保健学系, 教授 (20397219)

Co-Investigator(Kenkyū-buntansha) 藤原 浩  金沢大学, 医学系, 教授 (30252456)
三枝 理博  金沢大学, 医学系, 教授 (20296552)
安藤 仁  金沢大学, 医学系, 教授 (50382875)
小野 政徳  東京医科大学, 医学部, 准教授 (70348712)
堀家 慎一  金沢大学, 疾患モデル総合研究センター, 准教授 (40448311)
鏡 真美 (関塚真美)  金沢大学, 保健学系, 教授 (60334786)
Project Period (FY) 2020-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2023: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2022: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2021: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2020: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Keywords概日リズム / 妊産褥婦 / セルフケアプログラム
Outline of Research at the Start

ヒトは、光と食事によって体内にある中枢時計と末梢時計を毎日リセットして、24時間周期の生活を送っている。ところが、現代は概日リズムの乱れを起こす生活習慣が一般化している。本研究では、特に周産期に焦点を当て、妊産褥婦の「光と食事」に関する生活習慣の違いによる概日リズムの乱れが、母子の周産期予後と関連するかを明らかにする。また育児期にも目を向け、親の概日リズムの乱れが育児行動にもたらす影響を明らかにする。さらに、「光と食事」に関する生活習慣を整える「概日リズムに基づく周産期セルフケアプログラム」が、親と子の健常性維持に有効であるかを検討する。

Outline of Final Research Achievements

Humans have an intrinsic rhythm that defines approximately 25 hours as a “day,” and they reset their central and peripheral clocks daily through light and meal, leading a 24-hour cycle that is in sync with the earth's rotation. Mothers during pregnancy and the postpartum period, however, tend to have circadian rhythms that are easily disrupted.
In this research project, we conducted a questionnaire survey of postpartum mothers in relation to circadian rhythms and prepared a paper. In addition, papers on the regulation and function of clock genes and the relationship between feeding and circadian rhythms were published using model animals.

Academic Significance and Societal Importance of the Research Achievements

産褥期の母親を対象として行なった概日リズムと関連する質問紙調査の結果は、今後の論文発表、並びに更なる研究継続により、産後の女性の心の健康維持に資する新たなセルフケアの提案につながる可能性がある。出産後、多くの母親にマタニティ・ブルーズが見られ、一部の母親は産後うつ病等の精神疾患を発症する。母親の産後の心の不調をセルフケアにより緩和することができれば、多くの母子とその家族にとって有益となると考える。

Report

(5 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Annual Research Report
  • 2021 Annual Research Report
  • 2020 Annual Research Report
  • Research Products

    (3 results)

All 2023 2022 2021

All Journal Article (3 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 3 results,  Open Access: 3 results)

  • [Journal Article] Imeglimin profoundly affects the circadian clock in mouse embryonic fibroblasts2023

    • Author(s)
      Miura Kotomi、Morishige Jun-ichi、Abe Jotaro、Xu Pingping、Shi Yifan、Jing Zheng、Nagata Naoto、Miyazaki Ryo、Sakane Naoki、Mieda Michihiro、Ono Masanori、Maida Yoshiko、Fujiwara Tomoko、Fujiwara Hiroshi、Ando Hitoshi
    • Journal Title

      Journal of Pharmacological Sciences

      Volume: 153 Issue: 4 Pages: 215-220

    • DOI

      10.1016/j.jphs.2023.10.001

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Sustained effect of habitual feeding time on daily rhythm of core body temperature in mice2022

    • Author(s)
      Ando Hitoshi、Nagata Naoto、Hosono Takashi、Hasan Nazmul、Morishige Jun-ichi、Daikoku Takiko、Maida Yoshiko、Ono Masanori、Fujiwara Tomoko、Fujiwara Hiroshi
    • Journal Title

      Frontiers in Nutrition

      Volume: 9 Pages: 966788-966788

    • DOI

      10.3389/fnut.2022.966788

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Brown adipocyte-specific knockout of Bmal1 causes mild but significant thermogenesis impairment in mice2021

    • Author(s)
      Hasan Nazmul、Nagata Naoto、Morishige Jun-ichi、Islam Md Tarikul、Jing Zheng、Harada Ken-ichi、Mieda Michihiro、Ono Masanori、Fujiwara Hiroshi、Daikoku Takiko、Fujiwara Tomoko、Maida Yoshiko、Ota Tsuguhito、Shimba Shigeki、Kaneko Shuichi、Fujimura Akio、Ando Hitoshi
    • Journal Title

      Molecular Metabolism

      Volume: 49 Pages: 101202-101202

    • DOI

      10.1016/j.molmet.2021.101202

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research

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Published: 2020-04-28   Modified: 2025-01-30  

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