| Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2023: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2022: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2021: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
Fiscal Year 2020: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
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| Outline of Final Research Achievements |
The purpose of this study was to investigate the effects of central insulin resistance observed in Alzheimer's disease (AD) on the exercise pressor response. Experiments simulating acute insulin resistance revealed that the “gain” of the neural center in the exercise pressor reflex was potentiated (input [stimulus] < output [pressor response]). In cognitively impaired rats with chronically induced brain insulin resistance, it has been suggested that the neural central gain of the exercise pressor reflex is reduced (input > output). We further tested whether central insulin administration modifies the attenuation of the pressor response induced by chronic insulin resistance. However, the expected results have not yet been obtained. These results may be useful in developing an exercise prescription and exercise guidance for AD patients with cerebral insulin resistance.
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