| Budget Amount *help |
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2023: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2022: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2021: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2020: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
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| Outline of Final Research Achievements |
Several studies revealed the novel regulatory mechanism of gene expression by histone H2AX, one of the proteins that play an important role in DNA double-strand break repair. In this study, we comprehensively analyzed the gene expression pattern in H2AX-deficient cells by RNA sequencing and found that the expression of genes involved in homologous recombination repair and the genes of signaling pathways for cell proliferation, adhesion, and differentiation were found was significantly upregulated even in non-damage-induced cells. These results propose a new function for H2AX, in which H2AX not only functions in genome stability during the occurrence of DNA damage, but also regulates gene expression to maintain homeostasis of the organism regardless DNA damage.
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