| Budget Amount *help |
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2022: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2021: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2020: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
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| Outline of Final Research Achievements |
We demonstrated that cells have mechanisms to tolerate for illudin S-induced DNA lesions. Importantly, the tolerance required PCNA ubiquitination but independently of DNA polymerase eta. We found that DNA polymerase kappa and RFWD3 play crucial roles independently to each other, but both dependently on PCNA ubiquitination. We published "RFWD3 and translesion DNA polymerases contribute to PCNA modification-dependent DNA damage tolerance".
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