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Understanding of functional roles and formation rules in cross-modal inhibition from motor cortices to visual cortices

Research Project

Project/Area Number 20H04492
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 90030:Cognitive science-related
Research InstitutionNational Institute of Information and Communications Technology (2021-2023)
Osaka University (2020)

Principal Investigator

Morita Tomoyo  国立研究開発法人情報通信研究機構, 未来ICT研究所脳情報通信融合研究センター, 主任研究員 (60543402)

Project Period (FY) 2020-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥15,080,000 (Direct Cost: ¥11,600,000、Indirect Cost: ¥3,480,000)
Fiscal Year 2023: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2022: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2021: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2020: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Keywords機能的MRI / クロスモーダル抑制 / 運動 / 発達 / Negative BOLD / Negative BOLD信号 / 視覚野 / 運動領野 / 視覚領野 / 可塑性
Outline of Research at the Start

脳神経系の抑制機能は、脳システムが適切に作動するために重要な役割を果たす。中でも、脳の機能領域間で起こる抑制は、ある領域が無関係な領域からの干渉を受けずに機能することを可能にすると想定されているが、その理解は大幅に遅れている。本研究では、成人を対象に運動中の脳活動を機能的MRIを用いて計測し、運動中に視覚領野でみられるクロスモーダル抑制(Negative BOLD現象)に着目し、この抑制の機能的役割、作用動態および発達に伴う形成過程など多角的な視点から包括的に理解することを目指す。

Outline of Final Research Achievements

Neuronal inhibition that occurs between functional brain regions is believed to allow one area to engage in a specific function without interference from unrelated regions, but the underlying mechanism is less understood. In this study, we investigated the functional roles, action dynamics, and formation process of cross-modal inhibition by focusing on the negative BOLD signals (inhibition) observed in the visual cortex during motor tasks that do not require vision. We found that inhibition in the visual cortex is related to reducing interference with other sensory information processing, that it varies depending on the activity state of the visual cortex, and that it is formed in dependence on the experience of using the visual cortex. These results suggest that during development, while the responsiveness of one sensory region increases, a system that can inhibit the area may be also formed simultaneously.

Academic Significance and Societal Importance of the Research Achievements

これまで、人の脳領域間の抑制機構に関して、主に成人の脳における現象の記述に留まる程度で、その理解は遅れていた。本研究では、成人に加えて、子供、高齢者、視覚障碍者を対象として、機能的MRIを用いてクロスモーダル抑制を多角的観点から調査した。一連の結果から、ある領域が発達に伴い反応性を獲得することに加え、その領域を抑制するシステムが同時に形成されることによって、脳システムの安定した作動が実現されている可能性が示唆された。これは、人の脳に対する理解を大きく前進させるだけでなく、人工知能システムの構築に対して新たな視点を付け加える重要な意義をもつ。

Report

(5 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Annual Research Report
  • 2021 Annual Research Report
  • 2020 Annual Research Report
  • Research Products

    (14 results)

All 2023 2022 2021 2020

All Journal Article (8 results) (of which Peer Reviewed: 7 results,  Open Access: 8 results) Presentation (6 results) (of which Int'l Joint Research: 4 results)

  • [Journal Article] Functional and Structural Properties of Interhemispheric Interaction between Bilateral Precentral Hand Motor Regions in a Top Wheelchair Racing Paralympian.2023

    • Author(s)
      Morita, T., Takemura, H., Naito, E.
    • Journal Title

      Brain sciences

      Volume: 13 Issue: 5 Pages: 715-715

    • DOI

      10.3390/brainsci13050715

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Structural and functional features characterizing the brains of individuals with higher controllability of motor imagery.2023

    • Author(s)
      Morita, T., Furuta, T., Miura, G., Naito, E.
    • Journal Title

      bioRxiv

      Volume: -

    • DOI

      10.1101/2023.10.11.560970

    • Related Report
      2023 Annual Research Report
    • Open Access
  • [Journal Article] Hyper-adaptation in the human brain: Functional and structural changes in the foot section of the primary motor cortex in a top wheelchair racing Paralympian.2022

    • Author(s)
      Morita, T., Hirose, S., Kimura, N., Takemura, H., Asada, M. & Naito, E.
    • Journal Title

      Frontier in System Neuroscience

      Volume: 16 Pages: 780652-780652

    • DOI

      10.3389/fnsys.2022.780652

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Facilitation of hand proprioceptive processing in paraplegic individuals with long-term wheelchair sports training.2022

    • Author(s)
      Morita, T. & Naito, E.
    • Journal Title

      Brain sciences

      Volume: 12 Issue: 10 Pages: 1295-1295

    • DOI

      10.3390/brainsci12101295

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Bimanual digit training improves right-hand dexterity in older adults by reactivating declined ipsilateral motor-cortical inhibition2021

    • Author(s)
      Naito, E., Morita, T., Hirose, S., Kimura, N., Okamoto, H., Kamimukai, C., & Asada, M.
    • Journal Title

      Scientific Reports

      Volume: 11 Issue: 1 Pages: 22696-22696

    • DOI

      10.1038/s41598-021-02173-7

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Existence of Interhemispheric Inhibition between Foot Sections of Human Primary Motor Cortices: Evidence from Negative Blood Oxygenation-Level Dependent Signal.2021

    • Author(s)
      Naito, E., Morita, T., Kimura, N. & Asada, M.
    • Journal Title

      Brain Sciences

      Volume: 11 Issue: 8 Pages: 1099-1099

    • DOI

      10.3390/brainsci11081099

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Examination of the development and aging of brain deactivation using a unimanual motor task2021

    • Author(s)
      Morita T, Asada M and Naito E
    • Journal Title

      Advanced Robotics

      Volume: ― Issue: 13-14 Pages: 1-16

    • DOI

      10.1080/01691864.2021.1886168

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Importance of the Primary Motor Cortex in Development of Human Hand/Finger Dexterity2020

    • Author(s)
      Naito Eiichi、Morita Tomoyo、Asada Minoru
    • Journal Title

      Cerebral Cortex Communications

      Volume: online ahead of print Issue: 1 Pages: 1-12

    • DOI

      10.1093/texcom/tgaa085

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Grey matter expansion of social brain networks in individuals high in public self-consciousness2023

    • Author(s)
      Morita, T., & Naito, E.
    • Organizer
      29th Annual Meeting of the Organization for Human Brain Mapping
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Bimanual training reactivates interhemispheric inhibition and improves hand dexterity in elderly2023

    • Author(s)
      Naito, E., Hirose, S. & Morita, T.
    • Organizer
      29th Annual Meeting of the Organization for Human Brain Mapping
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Promotion of cross-modal and default mode network inhibitions in young racing car drivers2022

    • Author(s)
      Morita, T., Asada, M. & Naito, E.
    • Organizer
      第45回日本神経科学学会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Developmental and age-related changes in brain deactivation during a unimanual motor task.2021

    • Author(s)
      Morita, T., Asada, M. & Naito, E
    • Organizer
      27th Annual Meeting of the Organization for Human Brain Mapping
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Tissue properties along the corticospinal tract of the wheelchair racing athlete: a case study.2021

    • Author(s)
      Takemura, H., Kimura, N., Morita, T. & Naito, E.
    • Organizer
      27th Annual Meeting of the Organization for Human Brain Mapping
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 運動課題中における活動抑制の発達的変化2020

    • Author(s)
      守田知代,浅田稔,内藤栄一
    • Organizer
      第43回日本神経科学大会
    • Related Report
      2020 Annual Research Report

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Published: 2020-04-28   Modified: 2025-01-30  

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