| Budget Amount *help |
¥197,340,000 (Direct Cost: ¥151,800,000、Indirect Cost: ¥45,540,000)
Fiscal Year 2024: ¥30,940,000 (Direct Cost: ¥23,800,000、Indirect Cost: ¥7,140,000)
Fiscal Year 2023: ¥37,700,000 (Direct Cost: ¥29,000,000、Indirect Cost: ¥8,700,000)
Fiscal Year 2022: ¥38,610,000 (Direct Cost: ¥29,700,000、Indirect Cost: ¥8,910,000)
Fiscal Year 2021: ¥42,510,000 (Direct Cost: ¥32,700,000、Indirect Cost: ¥9,810,000)
Fiscal Year 2020: ¥47,580,000 (Direct Cost: ¥36,600,000、Indirect Cost: ¥10,980,000)
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| Outline of Final Research Achievements |
This study analyzed the role of cohesin in regulating transcription elongation and revealed that cohesin has two distinct functions near the transcription start site. One is to promote enhancer-promoter interactions and positively regulate the formation of the transcription initiation complex; the other is to stabilize the paused state of RNA polymerase II (Pol II). Using a mathematical model, we demonstrated that gene expression changes observed upon cohesin depletion can be quantitatively explained by the combined effects of these two functions. This work highlights the dual role of cohesin in transcriptional regulation and its contribution to RNA quality control, providing important insights into the mechanisms of gene expression regulation. These findings may have potential applications in disease research and drug development.
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