血栓形成の制御を目指した多数のジスルフィド結合を持つ天然物様環状ペプチドの開発
Project/Area Number |
20J11284
|
Research Category |
Grant-in-Aid for JSPS Fellows
|
Allocation Type | Single-year Grants |
Section | 国内 |
Review Section |
Basic Section 37020:Chemistry and chemical methodology of biomolecules-related
|
Research Institution | The University of Tokyo |
Principal Investigator |
LIU Wenyu 東京大学, 理学系研究科, 特別研究員(DC2)
|
Project Period (FY) |
2020-04-24 – 2022-03-31
|
Project Status |
Completed (Fiscal Year 2021)
|
Budget Amount *help |
¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 2021: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 2020: ¥900,000 (Direct Cost: ¥900,000)
|
Keywords | disulfide-rich peptide / in vitro selection / peptide discovery / disulfide-rich peptides |
Outline of Research at the Start |
This research aims at ribosomal synthesis of a potential drug template, disulfide-rich cyclic peptides, with desired conformation, by in vitro incorporation of chemically protected amino acids and stepwise formation of disulfide bonds.
|
Outline of Annual Research Achievements |
This research aims at discovery of de novo disulfide-rich peptides (DRPs) with desired conformations and biological activities using in vitro selection. In this year of my JSPS fellowship, I first finished the paper publication of the research that identified an ultrapotent cyclotide-based FXIIa inhibitor. This work was published on J. Am. Chem. Soc. 2021, 143, 18481-18489. In this year, I also continued the research of controlling disulfide connectivity in DRPs taking advantage of protected cysteines. In brief, I constructed bicyclic or tricyclic DRP libraries with controllable disulfide conformations and conducted in vitro selection to yield several potent target-binding peptides with designed structures. The following work is being performed and will be summarized into publications.
|
Research Progress Status |
令和3年度が最終年度であるため、記入しない。
|
Strategy for Future Research Activity |
令和3年度が最終年度であるため、記入しない。
|
Report
(2 results)
Research Products
(5 results)