| Project/Area Number |
20J11284
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| Research Category |
Grant-in-Aid for JSPS Fellows
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| Allocation Type | Single-year Grants |
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| Section | 国内 |
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| Review Section |
Basic Section 37020:Chemistry and chemical methodology of biomolecules-related
|
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| Research Institution | The University of Tokyo |
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Principal Investigator |
LIU Wenyu 東京大学, 理学系研究科, 特別研究員(DC2)
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| Project Period (FY) |
2020-04-24 – 2022-03-31
|
| Project Status |
Completed (Fiscal Year 2021)
|
| Budget Amount *help |
¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 2021: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 2020: ¥900,000 (Direct Cost: ¥900,000)
|
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| Keywords | disulfide-rich peptide / in vitro selection / peptide discovery / disulfide-rich peptides |
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| Outline of Research at the Start |
This research aims at ribosomal synthesis of a potential drug template, disulfide-rich cyclic peptides, with desired conformation, by in vitro incorporation of chemically protected amino acids and stepwise formation of disulfide bonds.
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| Outline of Annual Research Achievements |
This research aims at discovery of de novo disulfide-rich peptides (DRPs) with desired conformations and biological activities using in vitro selection. In this year of my JSPS fellowship, I first finished the paper publication of the research that identified an ultrapotent cyclotide-based FXIIa inhibitor. This work was published on J. Am. Chem. Soc. 2021, 143, 18481-18489. In this year, I also continued the research of controlling disulfide connectivity in DRPs taking advantage of protected cysteines. In brief, I constructed bicyclic or tricyclic DRP libraries with controllable disulfide conformations and conducted in vitro selection to yield several potent target-binding peptides with designed structures. The following work is being performed and will be summarized into publications.
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| Research Progress Status |
令和3年度が最終年度であるため、記入しない。
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| Strategy for Future Research Activity |
令和3年度が最終年度であるため、記入しない。
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