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Research on brain fluorescence imaging without craniotomy light through scattering medium

Research Project

Project/Area Number 20K04517
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 21030:Measurement engineering-related
Research InstitutionSeikei University (2022-2023)
University of Miyazaki (2020-2021)

Principal Investigator

Nakano Kazuya  成蹊大学, 理工学部, 准教授 (80713833)

Project Period (FY) 2020-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2022: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2021: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2020: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords位相回復 / スペックル / 散乱光 / 位相回復アルゴリズム / 光散乱イメージング / 光伝搬モンテカルロ法 / 生体イメージング / スペックル相関 / 散乱媒質 / 蛍光イメージング / 生体医用光学 / 生体組織イメージング
Outline of Research at the Start

現在,生体組織の観察においては,生体組織による光の散乱により生体内部の像にボケが生じてしまうことが問題とされている.特に,脳組織の観察においては,頭蓋骨が高散乱体であるため,頭蓋骨を外科的に除去(開頭)するが,出血を回避することは難しく脳にダメージを与えてしまう.そこで,これらの問題に対して,本研究では、光学的メモリー効果を応用して開頭せずに観察する生体蛍光撮像法の基礎研究を実施する.

Outline of Final Research Achievements

In this study, we conducted a basic research to reconstruct the image of an object before passing through the scattering medium from the light scattered by the scattering medium. Experiments were conducted using scattering media ranging from a diffuser to a phantom. Several imaging systems for the image reconstruction were tested. In addition, we focused on the optical memory effect, which is used as a reconstruction principle, and constructed an optical system to investigate it. The image reconstruction was successful under certain conditions, and the optical memory effect was also confirmed.

Academic Significance and Societal Importance of the Research Achievements

生体組織といった散乱媒質中の物体を光によりイメージングしようとすると,光が散乱や吸収されることから,媒質の厚さや散乱係数などにより媒質中の物体を確認することが困難になる.本研究ではそのような散乱媒質を通過した光から物体像を再構成及びその原理となっているoptical memory effectに対する基礎的な研究を実施している.本成果が散乱媒質中の物体を観察するアプローチの1つになるものと考えている.

Report

(5 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • 2020 Research-status Report
  • Research Products

    (5 results)

All 2021 2020 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (3 results) (of which Int'l Joint Research: 2 results,  Invited: 2 results) Remarks (1 results)

  • [Journal Article] Analysis of singular phase based on double random phase encoding using phase retrieval algorithm2020

    • Author(s)
      Nakano Kazuya、Suzuki Hiroyuki
    • Journal Title

      Optics and Lasers in Engineering

      Volume: 134 Pages: 106300-106300

    • DOI

      10.1016/j.optlaseng.2020.106300

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Basic Research on Brain Fluorescence Imaging without Craniotomy2021

    • Author(s)
      Kazuya Nakano
    • Organizer
      Symposium on Multimodal Medical Engineering (MME, 2021) THE 2nd FINNISH - JAPANESE MEDICAL PHOTONICS SYMPOSIUM (ONLINE)
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Hemodynamics imaging based on digital color images2020

    • Author(s)
      Kazuya Nakano, Izumi Nishidate
    • Organizer
      The 10th Japan-Korea Workshop on Digital Holography & Information Photonics (DHIP 2020)
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 可視光線に基づく血行動態イメージング2020

    • Author(s)
      中野和也
    • Organizer
      レーザー学会第546回研究報告
    • Related Report
      2020 Research-status Report
  • [Remarks] 中野研究室ホームページ

    • URL

      https://sites.google.com/view/nakano-lab/home

    • Related Report
      2020 Research-status Report

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Published: 2020-04-28   Modified: 2025-01-30  

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