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Development of supercritical fluid extraction method to solve various problems of entrainer

Research Project

Project/Area Number 20K05192
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 27010:Transport phenomena and unit operations-related
Research InstitutionNagoya University

Principal Investigator

Kanda Hideki  名古屋大学, 工学研究科, 助教 (90371624)

Project Period (FY) 2020-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2022: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2021: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords液化ジメチルエーテル / 超臨界二酸化炭素 / 抽出 / 溶媒 / DNA / 脱細胞化 / リポソーム / エントレーナー / 脂質 / 超臨界流体 / 亜臨界流体 / 助溶媒 / 天然物化学
Outline of Research at the Start

超臨界CO2に液体の極性溶媒(エントレーナー)を混合して、超臨界CO2に不溶な極性物質を抽出可能にする手法は古くから広く研究されているが、エントレーナーが残留する、エントレーナーの種類によっては作業環境中の空気が汚染される、超臨界CO2へのエントレーナーの溶解度が低い場合は極性物質の抽出に限界があるといった問題がある。そこで、沸点が-24.8℃で残留の懸念が無く、毒性が無く、弱極性で、超臨界CO2に完全混合する液化ジメチルエーテル(DME)を世界で初めてエントレーナーとして用いることで、従来のエントレーナーが抱える問題を解決する。

Outline of Final Research Achievements

Extraction of neutral lipids from soybean lipids was attempted using a DME/SC-CO2 mixture system, and the effects of DME in promoting extraction and reducing operating pressure were confirmed. In addition, the extraction of curcumin from turmeric and the extraction of lipids from microalgae were also improved by the DME/SC-CO2 mixture system. In an attempt to apply the extraction properties of liquefied DME, liposomes were successfully produced from phospholipids using liquefied DME as a medium, and this is currently being expanded to a DME/SC-CO2 mixture system. We have also succeeded in producing scaffolds for DNA extraction and removal from ostrich carotid artery, porcine brain, porcine cartilage, and porcine aorta using liquefied DME and DNase in combination, achieving results beyond our initial plans.

Academic Significance and Societal Importance of the Research Achievements

代表的なグリーン溶媒である超臨界二酸化炭素(SC-CO2)に液体の助溶媒(エントレーナー)を混合して、SC-CO2による抽出量を増大させる手法は古くから研究されているが、抽出物や残渣にエントレーナーが残留する、作業環境中の空気が汚染される問題がある。一方で近年グリーン溶媒として注目されている液化ジメチルエーテル(DME)は沸点が-24.8℃で残留の懸念が無く毒性が僅かで安価で微極性という多くの利点がある。このDMEの溶媒としての特性を明らかにするとともに、DMEをSC-CO2のエントレーナーとして用いる手法を開発すれば、従来のグリーン溶媒抽出の環境調和性や操作条件の改善が期待できる。

Report

(4 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • Research Products

    (26 results)

All 2023 2022 2021 2020 Other

All Int'l Joint Research (1 results) Journal Article (10 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 10 results,  Open Access: 9 results) Presentation (13 results) (of which Int'l Joint Research: 1 results,  Invited: 2 results) Book (2 results)

  • [Int'l Joint Research] スラバヤ工科大学(インドネシア)

    • Related Report
      2022 Annual Research Report
  • [Journal Article] Surfactant free decellularization of porcine auricular cartilage using liquefied dimethyl ether and DNase2023

    • Author(s)
      Hideki Kanda, Kento Oya, Wahyudiono, Motonobu Goto
    • Journal Title

      Materials

      Volume: 16 Issue: 8 Pages: 3172-3172

    • DOI

      10.3390/ma16083172

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Tensile strength of ostrich carotid artery decellularized with liquefied dimethyl ether and DNase: An effort in addressing religious and cultural concerns2023

    • Author(s)
      Hideki Kanda, Kento Oya, Toshihira Irisawa, Wahyudiono, Motonobu Goto
    • Journal Title

      Arabian Journal of Chemistry

      Volume: 16 Issue: 4 Pages: 104578-104578

    • DOI

      10.1016/j.arabjc.2023.104578

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Ethanol-free extraction of curcumin and antioxidant activity of components from Curcuma longa L by liquefied dimethyl ether2023

    • Author(s)
      Hideki Kanda, Li Zhu, Wanying Zhu, Tao Wang
    • Journal Title

      Arabian Journal of Chemistry

      Volume: 16 Issue: 4 Pages: 104585-104585

    • DOI

      10.1016/j.arabjc.2023.104585

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Tensile Strength of Porcine Aorta Tissue Decellularized by Liquefied Dimethyl Ether and DNase2022

    • Author(s)
      Hideki Kanda, Kento Oya, Toshihira Irisawa, Wahyudiono, Motonobu Goto
    • Journal Title

      ACS Omega

      Volume: 7 Issue: 38 Pages: 34449-34453

    • DOI

      10.1021/acsomega.2c04103

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Surfactant-free decellularization of porcine aortic tissue by subcritical dimethyl ether2021

    • Author(s)
      Hideki Kanda, Daigo Ando, Rintaro Hoshino, Tetsuya Yamamoto, Wahyudiono, Shogo Suzuki, Satoshi Shinohara, Motonobu Goto
    • Journal Title

      ACS Omega

      Volume: 6 Issue: 20 Pages: 13417-13425

    • DOI

      10.1021/acsomega.1c01549

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Enhancement of lipid extraction from soya bean by addition of dimethyl ether as entrainer into supercritical carbon dioxide2021

    • Author(s)
      Hideki Kanda, Yuji Fukuta, Wahyudiono, Motonobu Goto
    • Journal Title

      Foods

      Volume: 10 Issue: 6 Pages: 1223-1223

    • DOI

      10.3390/foods10061223

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Surfactant free decellularization of ostrich carotid artery tissue by liquefied dimethyl ether and DNase2021

    • Author(s)
      Hideki Kanda, Daigo Ando, Kento Oya, Wahyudiono, Motonobu Goto
    • Journal Title

      Arabian Journal of Chemistry

      Volume: 14 Issue: 8 Pages: 103280-103280

    • DOI

      10.1016/j.arabjc.2021.103280

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Preparation of liposomes of soy lecithin using liquefied dimethyl ether2021

    • Author(s)
      Hideki Kanda, Tsubasa Katsube, Wahyudiono, Motonobu Goto
    • Journal Title

      Foods

      Volume: 10 Issue: 8 Pages: 1789-1789

    • DOI

      10.3390/foods10081789

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Ethanol‐free extraction of resveratrol and its glycoside from Japanese knotweed rhizome by liquefied dimethyl ether without pretreatments2021

    • Author(s)
      Kanda Hideki、Oishi Kazuma、Machmudah Siti、Wahyudiono、Goto Motonobu
    • Journal Title

      Asia-Pacific Journal of Chemical Engineering

      Volume: 16 Issue: 2

    • DOI

      10.1002/apj.2600

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Direct Extraction of Lutein from Wet Macroalgae by Liquefied Dimethyl Ether without Any Pretreatment2020

    • Author(s)
      Kanda Hideki、Wahyudiono、Machmudah Siti、Goto Motonobu
    • Journal Title

      ACS Omega

      Volume: 5 Issue: 37 Pages: 24005-24010

    • DOI

      10.1021/acsomega.0c03358

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] クロレラの高分子凝集体からの液化ジメチルエーテルを用いた油脂抽出挙動の解明2023

    • Author(s)
      楠美海斗、王涛、朱力、米澤璃穂、本間亮介、山本徹也、塩田憲司、高岡昌輝、大下和徹、神田 英輝
    • Organizer
      化学工学会第88年会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 液化ジメチルエーテルによる高含水ウコンからのクルクミンと脂質の抽出2023

    • Author(s)
      Li Zhu、Wang Tao、Wangying Zhu、神田 英輝
    • Organizer
      化学工学会第88年会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 液化ジメチルエーテルによる高含水珪藻からのフコキサンチンと脂質の直接抽出2023

    • Author(s)
      Wang Tao、Li Zhu、楠美海斗、神田 英輝
    • Organizer
      化学工学会第88年会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 液化ジメチルエーテルによるクロレラからの脂質抽出に対する高分子凝集剤の影響2023

    • Author(s)
      楠美海斗、王涛、朱力、徐波、米澤璃穂、本間亮介、山本徹也、塩田憲司、高岡昌輝、大下和徹、神田 英輝
    • Organizer
      第45回京都大学環境衛生工学研究会シンポジウム
    • Related Report
      2022 Annual Research Report
  • [Presentation] Direct extraction of fucoxanthin and lipids from highly hydrous diatoms by liquefied dimethylether2023

    • Author(s)
      Tao Wang, Li Zhu, Kaito Kusumi, Xu Bo, Hideki Kanda
    • Organizer
      The 20th The Asian Pacific Confederation of Chemical Engineering
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 液化ジメチルエーテルとDNaseにより脱細胞化された動脈組織の引張強度の検討2022

    • Author(s)
      神田 英輝, 大矢 健登、入澤 寿平、Wayhudiono, 後藤元信
    • Organizer
      化学工学会第53回秋季大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] ポリマー系凝集剤の液化ジメチルエーテルへの溶解性の検討2022

    • Author(s)
      楠美海斗、Li Zhu、Wang Tao、神田 英輝
    • Organizer
      第53回中部化学関係学協会支部連合秋季大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 液化ジメチルエーテル(DME)を用いたウコンからのクルクミンと抗酸化物質の抽出2022

    • Author(s)
      Wang Tao、Li Zhu、Wangying Zhu、神田 英輝
    • Organizer
      分離技術会年会2022
    • Related Report
      2022 Annual Research Report
  • [Presentation] 超臨界CO2貧溶媒晶析法を用いたジテルペン抽出物と親水性高分子の複合粒子の創成2022

    • Author(s)
      張葉林、Wahyudiono、Ratana Rujiravanit、神田 英輝, 後藤元信
    • Organizer
      分離技術会年会2022
    • Related Report
      2022 Annual Research Report
  • [Presentation] ポリマー系凝集剤の液化ジメチルエーテルによる抽出挙動の検討2022

    • Author(s)
      楠美海斗、Li Zhu、Wang Tao、神田 英輝
    • Organizer
      分離技術会年会2022
    • Related Report
      2022 Annual Research Report
  • [Presentation] 化学工学会産学官連携センター・グローバルテクノロジー委員会2022

    • Author(s)
      神田 英輝
    • Organizer
      微細藻類の化成品やバイオ燃料への転換における課題と研究開発
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 微細藻類がカーボンニュートラルな食べ物や燃料になるための課題とは2022

    • Author(s)
      神田 英輝
    • Organizer
      あいちサイエンスフェスティバル
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] ジメチルエーテルの超臨界二酸化炭素への添加による脂質抽出の促進2022

    • Author(s)
      神田英輝, 福田祐士、Wayhudiono, 後藤元信
    • Organizer
      化学工学会第87回年会
    • Related Report
      2021 Research-status Report
  • [Book] 高圧力の科学・技術事典2022

    • Author(s)
      日本高圧力学会
    • Total Pages
      500
    • Publisher
      朝倉書店
    • ISBN
      9784254102970
    • Related Report
      2022 Annual Research Report
  • [Book] Advances in Food Science2021

    • Author(s)
      Hideki Kanda, Yuji Fukuta, Wahyudiono, Motonobu Goto
    • Total Pages
      500
    • Publisher
      Vide Leaf
    • ISBN
      9789390014255
    • Related Report
      2021 Research-status Report

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Published: 2020-04-28   Modified: 2024-01-30  

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