| Project/Area Number |
20K05260
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 28030:Nanomaterials-related
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| Research Institution | Gunma National College of Technology (2021-2023)
Saitama University (2020) |
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Principal Investigator |
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| Project Period (FY) |
2020-04-01 – 2024-03-31
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| Project Status |
Completed (Fiscal Year 2023)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2022: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2021: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2020: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | Nanomedicine / Nanomachines / Drug delivery systems / CAR T Immunotherapy / Adoptive therapy / Noninvasive chemotherapy / Nanozyme / Cancer / Nanotechnology / Breast cancer / Theranostic nanomachines / CAR T cell immunotherapy / Solid tumors / theranostics nanozyme / normoxia condition / B16-F10 melanoma / ATPase activity / breast cancer / noninvasive chemotherapy / Theranostic nanomachine / artificial nanozyme / carbon nanodots / breast cancer cells / Carbon nanodots / Photosensitization / Nanoparticles / Cancer cells / Light therapy / Theranosctics |
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| Outline of Research at the Start |
A new design of light-triggered nanomachines, which harvest and convert irradiation energy into reactive oxygen species is proposed. They are made from nontoxic carbon nanodots and aptamer. The nanomachines can target cancer cells with its aptamer and induce their programmed death by singlet oxygen.
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| Outline of Final Research Achievements |
Programmable nanodevices engineered for external activation were designed to facilitate cancer diagnosis and therapeutic treatment. Artificial nanozyme employing carbon nanodots was highlighted as a versatile platform for theranostic nanomachines. It integrates logic control systems, leveraging fluorescent responses to chemical or biological stimuli. This platform exhibits effectiveness in inhibiting breast cancer cells and regulating their metastatic migration through NIR irradiation, suggesting applications in photothermal and photodynamic therapy. Under normoxic conditions, the nanozymes regulate metastatic migration while demonstrating biocompatibility across various cellular assays. The therapeutic dosage was remarkably low, with no discernible adverse effects on healthy cellular pathways. The developed nanodevices were capable to reshape the tumor microenvironment, thereby establishing a therapeutic opportunity for effective adoptive therapy in treating of solid malignancies.
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| Academic Significance and Societal Importance of the Research Achievements |
The scientific significance is underscored by the advancement of innovative programmable nanodevices which serve as a versatile theranostic platform, offering effective strategies for cancer treatment. The social significance is tied to the achievement of enhanced cancer diagnosis and medication.
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