| Project/Area Number |
20K05576
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 34030:Green sustainable chemistry and environmental chemistry-related
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| Research Institution | Tokyo Metropolitan University (2021)
Hokkaido University (2020) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
Siddiki Hakim 北海道大学, 触媒科学研究所, 特任助教 (60722650)
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| Project Period (FY) |
2020-04-01 – 2022-03-31
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| Project Status |
Discontinued (Fiscal Year 2021)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2022: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2021: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2020: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | Heterogeneous catalysis / Step-efficient Synthesis / Oncology drug / Heterogeneous Catalysis / API Intermediates / Green Synthesis / Acceptorless / Metal nanoparticles |
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| Outline of Research at the Start |
This research focuses on the step efficient green heterogeneous catalysis of supported metal nanoparticles and Lewis acid-base incorporated catalysis of metal oxides for the synthesis of life-saving nib group oncology drug intermediates. It is identified that acceptorless dehydrogenative coupling, hydrogen transfer type coupling, and acid-base promoted condensation type reaction methods are the most vital issues for this green synthesis. In this study, I will develop new catalytic methods for selective and efficient synthesis of oncology APIs.
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| Outline of Annual Research Achievements |
To develop the heterogeneous catalytic methods for the proposed plan, the reactions (1) Dehydrogenative selective methylation and reductive amination of 2-aminobenzamide derivative to quinazolin-4-amine derivative, (2) Dehydrogenative heterocyclization reaction of 1,2-diamino benzene derivative in reaction with methanol produced benzimidazole derivatives, and (3) Hydrolysis of triglycerides to fatty acids are being demonstrated by employing sustainable and environmentally benign green synthesis methods.
For the reactions 1-3 we identified effective catalysts. Further optimization, demonstration, kinetics and mechanistic studies are underway for reactions 1 and 2. For the reaction 3 we have already submitted the paper and it is under review.
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